Calorie Restriction Promotes Mitochondrial Biogenesis by Inducing the Expression of eNOS

Science ◽  
2005 ◽  
Vol 310 (5746) ◽  
pp. 314-317 ◽  
Author(s):  
E. Nisoli
Keyword(s):  
Calorie Restriction ◽  
Mitochondrial Biogenesis

scholarly journals Artemisinin mimics calorie restriction to trigger mitochondrial biogenesis and compromise telomere shortening in mice

PeerJ ◽  
2015 ◽  
Vol 3 ◽  
pp. e822 ◽  
Author(s):  
Da-Ting Wang ◽  
Jiang He ◽  
Ming Wu ◽  
Si-Ming Li ◽  
Qian Gao ◽  
...  
Keyword(s):  
Calorie Restriction ◽  
Mitochondrial Biogenesis ◽  
Telomere Shortening

scholarly journals Does calorie restriction induce mitochondrial biogenesis? A reevaluation

2010 ◽  
Vol 25 (2) ◽  
pp. 785-791 ◽  
Author(s):  
Chad R. Hancock ◽  
Dong‐Ho Han ◽  
Kazuhiko Higashida ◽  
Sang Hyun Kim ◽  
John O. Holloszy
Keyword(s):  
Calorie Restriction ◽  
Mitochondrial Biogenesis

scholarly journals Combined effects of resistance training and calorie restriction on mitochondrial fusion and fission proteins in rat skeletal muscle

2016 ◽  
Vol 121 (3) ◽  
pp. 806-810 ◽  
Author(s):  
Yu Kitaoka ◽  
Koichi Nakazato ◽  
Riki Ogasawara
Keyword(s):  
Skeletal Muscle ◽  
Resistance Training ◽  
Calorie Restriction ◽  
Mitochondrial Biogenesis ◽  
Muscle Hypertrophy ◽  
Mitochondrial Fusion ◽  
Peroxisome Proliferator ◽  
Rat Skeletal Muscle ◽  
Muscle Weight ◽  
Peroxisome Proliferator Activated Receptor

Recent studies have demonstrated that resistance exercise leads not only to muscle hypertrophy, but it also improves mitochondrial function. Because calorie restriction (CR) has been suggested as a way to induce mitochondrial biogenesis, we examined the effects of resistance training with or without CR on muscle weight and key mitochondrial parameters in rat skeletal muscle. Four weeks of resistance training (thrice/wk) resulted in increased gastrocnemius muscle weight by 14% in rats fed ad libitum (AL). The degree of muscle-weight increase via resistance training was lower in rats with CR (7.4%). CR showed no effect on phosphorylation of mammalian target of rapamycin (mTOR) signaling proteins rpS6 and ULK1. Our results revealed that CR resulted in elevated levels of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) protein, a known master regulator of mitochondrial biogenesis. Resistance training alone also resulted in increased PGC-1α levels in skeletal muscle. The magnitude of the increase in PGC-1α was similar in rats in both the CR and AL groups. Moreover, we found that resistance training with CR resulted in elevated levels of proteins involved in mitochondrial fusion (Opa1 and Mfn1), and oxidative phosphorylation, whereas there was no effect of CR on the fission-regulatory proteins Fis1 and Drp1. These results indicate that CR attenuates resistance training-induced muscle hypertrophy, and that it may enhance mitochondrial adaptations in skeletal muscle.

scholarly journals Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans

PLoS Medicine ◽  
2007 ◽  
Vol 4 (3) ◽  
pp. e76 ◽  
Author(s):  
Anthony E Civitarese ◽  
Stacy Carling ◽  
Leonie K Heilbronn ◽  
Mathew H Hulver ◽  
Barbara Ukropcova ◽  
...  
Keyword(s):  
Calorie Restriction ◽  
Mitochondrial Biogenesis ◽  
Healthy Humans

scholarly journals Mild Mitochondrial Uncoupling and Calorie Restriction Increase Fasting eNOS, Akt and Mitochondrial Biogenesis

PLoS ONE ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. e18433 ◽  
Author(s):  
Fernanda M. Cerqueira ◽  
Francisco R. M. Laurindo ◽  
Alicia J. Kowaltowski
Keyword(s):  
Calorie Restriction ◽  
Mitochondrial Biogenesis ◽  
Mitochondrial Uncoupling
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