Antagonistic Control of Disease Resistance Protein Stability in the Plant Immune System

Science ◽  
2005 ◽  
Vol 309 (5736) ◽  
pp. 929-932 ◽  
Author(s):  
B. F. Holt
Keyword(s):  
Disease Resistance ◽  
Immune System ◽  
Protein Stability ◽  
Plant Immune System ◽  
Disease Resistance Protein ◽  
Resistance Protein ◽  
Antagonistic Control

scholarly journals Characterization of blast resistance related protein domains in wheat for molecular marker development

2019 ◽  
Vol 17 (2) ◽  
pp. 161-171
Author(s):  
M. Thoihidul Islam ◽  
Mohammad Rashid Arif ◽  
Arif Hasan Khan Robin
Keyword(s):  
Disease Resistance ◽  
Blast Resistance ◽  
Protein Domains ◽  
Protein Domain ◽  
Leucine Rich Repeat ◽  
Related Protein ◽  
Disease Resistance Protein ◽  
Protein Encoding ◽  
Resistance Protein ◽  
Lrr Protein

Wheat blast is a devastating disease which is baffling scientists from its inception. This study characterized the blast resistance related protein domains with a view to develop molecular markers to identify resistant wheat genotypes against Blast fungus Magnaporthe oryzae. A genome browse analysis detected that the candidate resistance gene against blast could be located in several different chromosomes. An in silico analysis was collected with fifty nucleotide-binding site leucine-rich repeat (NBS-LRR), leucine-rich repeat (LRR), pathogenesis and resistance protein-encoding accessions on the basis of the previous resistance report. The phylogenetic tree of those putative resistance accessions, bearing resistance related protein-encoding domains, showed that an NBS-LRR accession JP957107.1 has 67% similarity with the disease resistance protein domain encoding accession of Brazilian resistant cultivar Thatcher. By contrast, the rice blast resistance Pita gene has 72% similarity with 18 pathogenesis protein domain encoding accessions. Among putative protein domains, disease resistance protein of Thatcher has 78% similarity with two NBS-LRR protein domains AAZ99757.1 and AAZ99757.1. Eighteen microsatellite markers were designed from eighteen putative NBS-LRR protein encoding accessions along with Piz3 marker. The 19 markers were unable to separate resistant and susceptible genotypes. Diffused versus conspicuous bands indicated either presence of insertion/deletion (InDel) or single nucleotide polymorphism (SNP) among wheat genotypes. Detection of InDel or SNP markers is a subject of further investigation. Additional markers are needed to be designed using new NBS-LRR, pathogenesis, coiled-coil (CC), translocated intimin receptor (TIR) resistance protein encoding accessions to find out markers specific for blast resistance. J. Bangladesh Agril. Univ. 17(2): 161–171, June 2019

scholarly journals The Chloroplastic Protein THF1 Interacts with the Coiled-Coil Domain of the Disease Resistance Protein N′ and Regulates Light-Dependent Cell Death

2016 ◽  
Vol 171 (1) ◽  
pp. 658-674 ◽  
Author(s):  
Louis-Philippe Hamel ◽  
Ken-Taro Sekine ◽  
Thérèse Wallon ◽  
Yuji Sugiwaka ◽  
Kappei Kobayashi ◽  
...  
Keyword(s):  
Cell Death ◽  
Disease Resistance ◽  
Coiled Coil ◽  
Coiled Coil Domain ◽  
Disease Resistance Protein ◽  
Dependent Cell ◽  
Resistance Protein

Using decoys to expand the recognition specificity of a plant disease resistance protein

Science ◽  
2016 ◽  
Vol 351 (6274) ◽  
pp. 684-687 ◽  
Author(s):  
S. H. Kim ◽  
D. Qi ◽  
T. Ashfield ◽  
M. Helm ◽  
R. W. Innes
Keyword(s):  
Disease Resistance ◽  
Plant Disease Resistance ◽  
Plant Disease ◽  
Recognition Specificity ◽  
Disease Resistance Protein ◽  
Resistance Protein

scholarly journals Stem Rust Spores Elicit Rapid RPG1 Phosphorylation

2010 ◽  
Vol 23 (12) ◽  
pp. 1635-1642 ◽  
Author(s):  
Jayaveeramuthu Nirmala ◽  
Tom Drader ◽  
Xianming Chen ◽  
Brian Steffenson ◽  
Andris Kleinhofs
Keyword(s):  
Disease Resistance ◽  
Stem Rust ◽  
Kinase Inhibitors ◽  
Durable Resistance ◽  
Kinase Domain ◽  
Protein Kinase Inhibitors ◽  
Disease Resistance Protein ◽  
Resistance Protein

Stem rust threatens cereal production worldwide. Understanding the mechanism by which durable resistance genes, such as Rpg1, function is critical. We show that the RPG1 protein is phosphorylated within 5 min by exposure to spores from avirulent but not virulent races of stem rust. Transgenic mutants encoding an RPG1 protein with an in vitro inactive kinase domain fail to phosphorylate RPG1 in vivo and are susceptible to stem rust, demonstrating that phosphorylation is a prerequisite for disease resistance. Protein kinase inhibitors prevent RPG1 phosphorylation and result in susceptibility to stem rust, providing further evidence for the importance of phosphorylation in disease resistance. We conclude that phosphorylation of the RPG1 protein by the kinase activity of the pK2 domain induced by the interaction with an unknown pathogen spore product is required for resistance to the avirulent stem rust races. The pseudokinase pK1 domain is required for disease resistance but not phosphorylation. The very rapid phosphorylation of RPG1 suggests that an effector is already present in or on the stem rust urediniospores when they are placed on the leaf surface. However, spores must be alive, as determined by their ability to germinate, in order to elicit RPG1 phosphorylation.

scholarly journals Activation of a plant nucleotide binding-leucine rich repeat disease resistance protein by a modified self protein

2012 ◽  
Vol 14 (7) ◽  
pp. 1071-1084 ◽  
Author(s):  
Brody J. DeYoung ◽  
Dong Qi ◽  
Sang-Hee Kim ◽  
Thomas P. Burke ◽  
Roger W. Innes
Keyword(s):  
Disease Resistance ◽  
Nucleotide Binding ◽  
Leucine Rich Repeat ◽  
Disease Resistance Protein ◽  
Resistance Protein

scholarly journals Genome-wide Identification of Powdery Mildew Resistance in Common Bean

2020 ◽  
Author(s):  
Papias Hongera Binagwa ◽  
Sy M. Traore ◽  
Marceline Egnin ◽  
Gregory C. Bernard ◽  
Inocent Ritte ◽  
...  
Keyword(s):  
Disease Resistance ◽  
Common Bean ◽  
Resistance Genes ◽  
Agronomic Traits ◽  
Association Studies ◽  
Significant Snps ◽  
Genome Wide Association Studies ◽  
Genome Wide ◽  
Disease Resistance Protein ◽  
Resistance Protein

Abstract Background: Genome-wide association studies (GWAS) was utilized to detect genetic variations related to the powdery mildew (PM) resistance and several agronomic traits in common bean. However, its application in common bean and the PM interactions to identify genes and their location in the common bean genome has not been fully addressed. Results: Genome-wide association studies (GWAS) through marker-trait association are useful molecular tools for the identification of disease resistance and other agronomic traits. SNP genotyping with a BeadChip containing 5398 SNPs was used to detect genetic variations related to resistance to PM disease in a panel of 206 genotypes grown under field conditions for two consecutive years. Significant SNPs identified on chromosomes 4 and 10 (Pv04 and Pv10) were repeatable, confirming the reliability of the phenotypic data scored from the genotypes grown in two locations within two years. A cluster of resistance genes was revealed on the chromosome 4 of common bean genome among which CNL and TNL like resistance genes were identified. Furthermore, two resistance genes Phavu_010G1320001g and Phavu_010G136800g were also identified on Pv10; further sequence analysis showed that these genes were homologs to the Arabidopsis disease resistance protein (RLM1A-like) and the putative disease resistance protein (At4g11170.1), respectively. Two LRR receptor-like kinases (RLK) were also identified on Pv11 in samples collected in 2018 only. Many genes encoding auxin-responsive protein, TIFY10A protein, growth-regulating factor 5-like, ubiquitin-like protein, cell wall protein RBR3-like protein related to PM resistance were identified nearby significant SNPs. These results suggested that the resistance to PM pathogen involves a network of many genes constitutively co-expressed and may generate several layers of defense barriers or inducible reactions.Conclusion: Our results provide new insights into common bean and PM interactions, and revealed putative resistance genes as well as their location on common bean genome that could be used for marker-assisted selection, functional genomic study approaches to confirm the role of these putative genes; hence, developing common bean resistance lines to the PM disease.

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