Integrase Inhibitors and Cellular Immunity Suppress Retroviral Replication in Rhesus Macaques

Science ◽  
2004 ◽  
Vol 305 (5683) ◽  
pp. 528-532 ◽  
Author(s):  
D. J. Hazuda
Keyword(s):  
Cellular Immunity ◽  
Rhesus Macaques ◽  
Integrase Inhibitors ◽  
Retroviral Replication

scholarly journals Roles of Target Cells and Virus-Specific Cellular Immunity in Primary Simian Immunodeficiency Virus Infection

2004 ◽  
Vol 78 (9) ◽  
pp. 4866-4875 ◽  
Author(s):  
Roland R. Regoes ◽  
Rustom Antia ◽  
David A. Garber ◽  
Guido Silvestri ◽  
Mark B. Feinberg ◽  
...  
Keyword(s):  
Virus Infection ◽  
Simian Immunodeficiency Virus ◽  
Cellular Immunity ◽  
Target Cell ◽  
Rhesus Macaques ◽  
Target Cells ◽  
Ongoing Debate ◽  
Data Set ◽  
Infection Period ◽  
Immunodeficiency Virus

ABSTRACT There is an ongoing debate on whether acute human immunodeficiency virus infection is controlled by target cell limitation or by virus-specific cellular immunity. To resolve this question, we developed a novel mathematical modeling scheme which allows us to incorporate measurements of virus load, target cells, and virus-specific immunity and applied it to a comprehensive data set generated in an experiment involving rhesus macaques infected with simian immunodeficiency virus. Half of the macaques studied were treated during the primary infection period with reagents which block T-cell costimulation and as a result displayed severely impaired virus-specific immune responses. Our results show that early viral replication in normal infection is controlled to a large extent by virus-specific CD8+ T cells and not by target cell limitation.

scholarly journals Strong interferon-gamma mediated cellular immunity to scrub typhus demonstrated using a novel whole cell antigen ELISpot assay in rhesus macaques and humans

2017 ◽  
Vol 11 (9) ◽  
pp. e0005846 ◽  
Author(s):  
Manutsanun Sumonwiriya ◽  
Daniel H. Paris ◽  
Piyanate Sunyakumthorn ◽  
Tippawan Anantatat ◽  
Kemajittra Jenjaroen ◽  
...  
Keyword(s):  
Interferon Gamma ◽  
Cellular Immunity ◽  
Elispot Assay ◽  
Scrub Typhus ◽  
Rhesus Macaques ◽  
Whole Cell ◽  
Cell Antigen

Vaccines for Therapeutic Cellular Immunity that Target HIV Gag, Pol and Nef Epitopes to CD40 and DCIR Elicit T-cell Responses in Rhesus Macaques

2014 ◽  
Vol 30 (S1) ◽  
pp. A245-A245 ◽  
Author(s):  
Yves Lévy ◽  
Sandra Zurawski ◽  
Anne-Laure Flamar ◽  
Christine Lacabaratz ◽  
Cécile Peltekian ◽  
...  
Keyword(s):  
T Cell ◽  
Cellular Immunity ◽  
Rhesus Macaques ◽  
T Cell Responses ◽  
Cell Responses

scholarly journals Cellular immunity induced by a novel HPV18 DNA vaccine encoding an E6/E7 fusion consensus protein in mice and rhesus macaques

Vaccine ◽  
2008 ◽  
Vol 26 (40) ◽  
pp. 5210-5215 ◽  
Author(s):  
Jian Yan ◽  
Kristina Harris ◽  
Amir S. Khan ◽  
Ruxandra Draghia-Akli ◽  
Duane Sewell ◽  
...  
Keyword(s):  
Dna Vaccine ◽  
Cellular Immunity ◽  
Rhesus Macaques

Spontaneous Cataract in Nude Athymic Mice

1977 ◽  
Vol 35 ◽  
pp. 512-513
Author(s):  
Ronald H. Bradley ◽  
R. S. Berk ◽  
L. D. Hazlett
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Nude Mouse ◽  
Cellular Immunity ◽  
Phosphate Buffer ◽  
Osmium Tetroxide ◽  
Athymic Mice ◽  
Transmission Microscopy ◽  
Mouse Lens ◽  
Scanning Electron

The nude mouse is a hairless mutant (homozygous for the mutation nude, nu/nu), which is born lacking a thymus and possesses a severe defect in cellular immunity. Spontaneous unilateral cataractous lesions were noted (during ocular examination using a stereomicroscope at 40X) in 14 of a series of 60 animals (20%). This transmission and scanning microscopic study characterizes the morphology of this cataract and contrasts these data with normal nude mouse lens.All animals were sacrificed by an ether overdose. Eyes were enucleated and immersed in a mixed fixative (1% osmium tetroxide and 6% glutaraldehyde in Sorenson's phosphate buffer pH 7.4 at 0-4°C) for 3 hours, dehydrated in graded ethanols and embedded in Epon-Araldite for transmission microscopy. Specimens for scanning electron microscopy were fixed similarly, dehydrated in graded ethanols, then to graded changes of Freon 113 and ethanol to 100% Freon 113 and critically point dried in a Bomar critical point dryer using Freon 13 as the transition fluid.

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