Tryptophan Hydroxylase-2 Controls Brain Serotonin Synthesis

Science ◽  
2004 ◽  
Vol 305 (5681) ◽  
pp. 217-217 ◽  
Author(s):  
X. Zhang
Keyword(s):  
Tryptophan Hydroxylase ◽  
Brain Serotonin ◽  
Serotonin Synthesis ◽  
Tryptophan Hydroxylase 2

scholarly journals Tryptophan hydroxylase 2 genotype determines brain serotonin synthesis but not tissue content in C57Bl/6 and BALB/c congenic mice

2010 ◽  
Vol 481 (1) ◽  
pp. 6-11 ◽  
Author(s):  
William B. Siesser ◽  
Xiaodong Zhang ◽  
Jacob P.R. Jacobsen ◽  
Tatyana D. Sotnikova ◽  
Raul R. Gainetdinov ◽  
...  
Keyword(s):  
Tryptophan Hydroxylase ◽  
Brain Serotonin ◽  
Serotonin Synthesis ◽  
Tryptophan Hydroxylase 2 ◽  
Congenic Mice ◽  
Tissue Content

scholarly journals The Intricate Biological Proximity of Vitamin D and Brain Serotonin

2021 ◽  
Vol 9 (12) ◽  
pp. 2096-2099
Author(s):  
Abhineet Maini
Keyword(s):  
Vitamin D ◽  
Clinical Trials ◽  
Tryptophan Hydroxylase ◽  
Current Understanding ◽  
Brain Serotonin ◽  
Autistic Children ◽  
Serotonin Synthesis ◽  
Tryptophan Hydroxylase 2

Abstract: Background: The purpose of this article is to extend and elaborate on our current understanding of Calcitriol and Brain Serotonin synthesis; particularly on how the two may be related. Methods: Using a 2014 study involving clinical trials to extend this hypothesis. Results: Vitamin D (Calcitriol) activated the gene that codes for Tryptophan Hydroxylase 2, which synthesizes Brain Serotonin. It also inhibits Tryptophan Hydroxylase 1, which makes serotonin in the gut. Conclusion: Vitamin D is closely related to the synthesis of Brain Serotonin. If furthered, it may be used as a treatment for the Serotonin Anomaly in Autistic Children. Keywords: 1. Biochemistry 2. Genetics 3. Neuroscience 4. Physiology

scholarly journals Brain serotonin deficiency leads to social communication deficits in mice

2015 ◽  
Vol 11 (3) ◽  
pp. 20150057 ◽  
Author(s):  
D. Beis ◽  
K. Holzwarth ◽  
M. Flinders ◽  
M. Bader ◽  
M. Wöhr ◽  
...  
Keyword(s):  
Tryptophan Hydroxylase ◽  
Sexual Preference ◽  
Brain Serotonin ◽  
Adult Males ◽  
Social Situations ◽  
Tryptophan Hydroxylase 2 ◽  
Social Contacts ◽  
Interaction Partners ◽  
Female Urine ◽  
Serotonin Deficiency

A deficit in brain serotonin is thought to be associated with deteriorated stress coping behaviour, affective disorders and exaggerated violence. We challenged this hypothesis in mice with a brain-specific serotonin depletion caused by a tryptophan hydroxylase 2 (TPH2) deficiency. We tested TPH2-deficient ( Tph2 −/– ) animals in two social situations. As juveniles, Tph2 −/− mice displayed reduced social contacts, whereas ultrasonic vocalizations (USVs) were unchanged within same-sex same-genotype pairings. Interestingly, juvenile females vocalized more than males across genotypes. Sexually naive adult males were exposed to fresh male or female urine, followed by an interaction with a conspecific, and re-exposed to urine. Although Tph2 −/− mice showed normal sexual preference, they were hyper-aggressive towards their interaction partners and did not vocalize in response to sexual cues. These results highlight that central serotonin is essential for prosocial behaviour, especially USV production in adulthood, but not for sexual preference.

Serotonin synthesis rate and the tryptophan hydroxylase-2: G-703T polymorphism in social anxiety disorder

2016 ◽  
Vol 30 (10) ◽  
pp. 1028-1035 ◽  
Author(s):  
Tomas Furmark ◽  
Ina Marteinsdottir ◽  
Andreas Frick ◽  
Kerstin Heurling ◽  
Maria Tillfors ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Social Anxiety ◽  
Social Anxiety Disorder ◽  
Tryptophan Hydroxylase ◽  
Synthesis Rate ◽  
Serotonin Synthesis ◽  
Tryptophan Hydroxylase 2

Targeted Manipulation of Brain Serotonin: RNAi-Mediated Knockdown of Tryptophan Hydroxylase 2 in Rats

2019 ◽  
Vol 10 (7) ◽  
pp. 3207-3217 ◽  
Author(s):  
Susann Matthes ◽  
Valentina Mosienko ◽  
Elena Popova ◽  
Marion Rivalan ◽  
Michael Bader ◽  
...  
Keyword(s):  
Tryptophan Hydroxylase ◽  
Brain Serotonin ◽  
Tryptophan Hydroxylase 2
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