Axonal Neuregulin-1 Regulates Myelin Sheath Thickness

Science ◽  
2004 ◽  
Vol 304 (5671) ◽  
pp. 700-703 ◽  
Author(s):  
G. V. Michailov
Keyword(s):  
Myelin Sheath ◽  
Sheath Thickness ◽  
Neuregulin 1 ◽  
Myelin Sheath Thickness

scholarly journals Neuregulin 1 type III reduces severity in a mouse model of Congenital Hypomyelinating Neuropathy

2018 ◽  
Author(s):  
Belin Sophie ◽  
Francesca Ornaghi ◽  
Ghjuvan'Ghjacumu Shackleford ◽  
Jie Wang ◽  
Cristina Scapin ◽  
...  
Keyword(s):  
Mouse Model ◽  
Cell Fate ◽  
Action Potentials ◽  
Sheath Thickness ◽  
Neuregulin 1 ◽  
Type Iii ◽  
Beneficial Effects ◽  
Axonal Protein ◽  
Congenital Hypomyelinating Neuropathy ◽  
Myelin Sheath Thickness

Myelin sheath thickness is precisely regulated and essential for rapid propagation of action potentials along myelinated axons. In the peripheral nervous system, extrinsic signals from the axonal protein neuregulin 1 type III regulate Schwann cell fate and myelination. Here we ask if modulating neuregulin 1 type III levels in neurons would restore myelination in a model of congenital hypomyelinating neuropathy (CHN). Using a mouse model of CHN, we rescued the myelination defects by early overexpression of neuregulin 1 type III. Surprisingly, the rescue was independent from the upregulation of Egr2 or essential myelin genes. Rather, we observed the activation of MAPK/ERK and other myelin genes such as peripheral myelin protein 2 (Pmp2) and oligodendrocyte myelin glycoprotein (Omg). We also confirmed that the permanent activation of MAPK/ERK in Schwann cells has detrimental effects on myelination. Our findings demonstrate that the modulation of axon-to-glial neuregulin 1 type III signaling has beneficial effects and restores myelination defects during development in a model of CHN.

Schwann cells and oligodendrocytes read distinct signals in establishing myelin sheath thickness

2001 ◽  
Vol 65 (6) ◽  
pp. 493-499 ◽  
Author(s):  
Gregory A. Elder ◽  
Victor L. Friedrich ◽  
Robert A. Lazzarini
Keyword(s):  
Schwann Cells ◽  
Myelin Sheath ◽  
Sheath Thickness ◽  
Myelin Sheath Thickness

scholarly journals Erratum to: Anosmin-1 over-expression regulates oligodendrocyte precursor cell proliferation, migration and myelin sheath thickness

2015 ◽  
Vol 221 (3) ◽  
pp. 1787-1787 ◽  
Author(s):  
Verónica Murcia-Belmonte ◽  
Pedro F. Esteban ◽  
José Martínez-Hernández ◽  
Agnès Gruart ◽  
Rafael Luján ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Myelin Sheath ◽  
Precursor Cell ◽  
Sheath Thickness ◽  
Oligodendrocyte Precursor Cell ◽  
Over Expression ◽  
Oligodendrocyte Precursor ◽  
Myelin Sheath Thickness
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