Comment on "On the Origin of Interictal Activity in Human Temporal Lobe Epilepsy in Vitro"

Science ◽  
2003 ◽  
Vol 301 (5632) ◽  
pp. 463c-463 ◽  
Author(s):  
C. Wozny
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Human Temporal Lobe

scholarly journals Cohen I, Navarro V, Clemenceau S, Baulac M, Miles R:On the origin of interictal activity in human temporal lobe epilepsy in vitro. Science 298:1418–1421, 2002

2003 ◽  
Vol 14 (2) ◽  
pp. 1
Author(s):  
William T. Couldwell
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Pyramidal Cells ◽  
Rhythmic Activity ◽  
Gamma Aminobutyric Acid ◽  
Ca1 Region ◽  
Interictal Discharges ◽  
Human Temporal Lobe ◽  
Spontaneous Rhythmic Activity

The origin and mechanisms of human interictal epileptic discharges remain unclear. Here, we describe a spontaneous, rhythmic activity initiated in the subiculum of slices from patients with temporal lobe epilepsy. Synchronous events were similar to interictal discharges of patient electroencephalograms. They were suppressed by antagonists of either glutamatergic or gamma-aminobutyric acid (GABA)-ergic signaling. The network of neurons discharging during population events comprises both subicular interneurons and a subgroup of pyramidal cells. In these pyramidal cells, GABAergic synaptic events reversed at depolarized potentials. Depolarizing GABAergic responses in neurons downstream to the sclerotic CA1 region contribute to human interictal activity.

CpG Methylation Signature Define Human Temporal Lobe Epilepsy and Predict Drug-Resistant

2019 ◽  
Author(s):  
Wenbiao Xiao ◽  
Chaorong Liu ◽  
Kuo Zhong ◽  
Shangwei Ning ◽  
Rui Hou ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Cpg Methylation ◽  
Drug Resistant ◽  
Human Temporal Lobe

scholarly journals Increased Reelin Promoter Methylation Is Associated With Granule Cell Dispersion in Human Temporal Lobe Epilepsy

2009 ◽  
Vol 68 (4) ◽  
pp. 356-364 ◽  
Author(s):  
Katja Kobow ◽  
Ina Jeske ◽  
Michelle Hildebrandt ◽  
Jan Hauke ◽  
Eric Hahnen ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Granule Cell ◽  
Promoter Methylation ◽  
Cell Dispersion ◽  
Human Temporal Lobe

scholarly journals In vitro ictogenesis and parahippocampal networks in a rodent model of temporal lobe epilepsy

2010 ◽  
Vol 39 (3) ◽  
pp. 372-380 ◽  
Author(s):  
G. Panuccio ◽  
M. D'Antuono ◽  
P. de Guzman ◽  
L. De Lannoy ◽  
G. Biagini ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Rodent Model

GABAB(1) mRNA expression in hippocampal sclerosis associated with human temporal lobe epilepsy

2001 ◽  
Vol 86 (1-2) ◽  
pp. 84-89 ◽  
Author(s):  
Andrew Billinton ◽  
Virginia H. Baird ◽  
Maria Thom ◽  
John S. Duncan ◽  
Neil Upton ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Mrna Expression ◽  
Temporal Lobe ◽  
Hippocampal Sclerosis ◽  
Human Temporal Lobe

Characterization of neurons in the cortical white matter in human temporal lobe epilepsy

Neuroscience ◽  
2016 ◽  
Vol 333 ◽  
pp. 140-150 ◽  
Author(s):  
Zsófia Richter ◽  
József Janszky ◽  
György Sétáló ◽  
Réka Horváth ◽  
Zsolt Horváth ◽  
...  
Keyword(s):  
White Matter ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Human Temporal Lobe
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