Fusion Pore Dynamics and Insulin Granule Exocytosis in the Pancreatic Islet

Science ◽  
2002 ◽  
Vol 297 (5585) ◽  
pp. 1349-1352 ◽  
Author(s):  
N. Takahashi
Keyword(s):  
Pancreatic Islet ◽  
Fusion Pore ◽  
Granule Exocytosis ◽  
Insulin Granule ◽  
Pore Dynamics

scholarly journals Dynamin-Related Protein-1 Controls Fusion Pore Dynamics During Platelet Granule Exocytosis

2013 ◽  
Vol 33 (3) ◽  
pp. 481-488 ◽  
Author(s):  
Secil Koseoglu ◽  
James R. Dilks ◽  
Christian G. Peters ◽  
Jennifer L. Fitch-Tewfik ◽  
Nathalie A. Fadel ◽  
...  
Keyword(s):  
Fusion Pore ◽  
Related Protein ◽  
Granule Exocytosis ◽  
Pore Dynamics

scholarly journals Plasma Membrane Order Regulates Insulin Granule Exocytosis

2020 ◽  
Vol 118 (3) ◽  
pp. 401a-402a
Author(s):  
Chase Amos ◽  
Noah Schenk ◽  
Volker Kiessling ◽  
Alex J. Kreutzberger ◽  
Weronika Tomaka ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Granule Exocytosis ◽  
Membrane Order ◽  
Insulin Granule

scholarly journals Fusion Pore Dynamics Are Regulated by Synaptotagmin•t-SNARE Interactions

Neuron ◽  
2004 ◽  
Vol 41 (6) ◽  
pp. 929-942 ◽  
Author(s):  
Jihong Bai ◽  
Chih-Tien Wang ◽  
David A Richards ◽  
Meyer B Jackson ◽  
Edwin R Chapman
Keyword(s):  
Fusion Pore ◽  
Pore Dynamics

scholarly journals Integration of ATP, cAMP, and Ca2+ Signals in Insulin Granule Exocytosis

Diabetes ◽  
2004 ◽  
Vol 53 (Supplement 3) ◽  
pp. S59-S62 ◽  
Author(s):  
T. Shibasaki ◽  
Y. Sunaga ◽  
S. Seino
Keyword(s):  
Granule Exocytosis ◽  
Insulin Granule

scholarly journals Direct Detection of Reconstituted, Snare-Mediated Fusion Pore Dynamics

2014 ◽  
Vol 106 (2) ◽  
pp. 506a
Author(s):  
Zhenyong Wu ◽  
Erdem Karatekin
Keyword(s):  
Direct Detection ◽  
Fusion Pore ◽  
Pore Dynamics

scholarly journals Interaction of ATP Sensor, cAMP Sensor, Ca2+Sensor, and Voltage-dependent Ca2+Channel in Insulin Granule Exocytosis

2003 ◽  
Vol 279 (9) ◽  
pp. 7956-7961 ◽  
Author(s):  
Tadao Shibasaki ◽  
Yasuhiro Sunaga ◽  
Kei Fujimoto ◽  
Yasushige Kashima ◽  
Susumu Seino
Keyword(s):  
Granule Exocytosis ◽  
Voltage Dependent ◽  
Insulin Granule

scholarly journals Fusion Pore Diameter Regulation by Cations Modulating Local Membrane Anisotropy

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Doron Kabaso ◽  
Ana I. Calejo ◽  
Jernej Jorgačevski ◽  
Marko Kreft ◽  
Robert Zorec ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Continuum Model ◽  
Pore Diameter ◽  
Fusion Pore ◽  
Spontaneous Curvature ◽  
Local Concentration ◽  
Vesicle Membrane ◽  
Membrane Elasticity ◽  
Opening And Closing ◽  
Pore Dynamics

The fusion pore is an aqueous channel that is formed upon the fusion of the vesicle membrane with the plasma membrane. Once the pore is open, it may close again (transient fusion) or widen completely (full fusion) to permit vesicle cargo discharge. While repetitive transient fusion pore openings of the vesicle with the plasma membrane have been observed in the absence of stimulation, their frequency can be further increased using a cAMP-increasing agent that drives the opening of nonspecific cation channels. Our model hypothesis is that the openings and closings of the fusion pore are driven by changes in the local concentration of cations in the connected vesicle. The proposed mechanism of fusion pore dynamics is considered as follows: when the fusion pore is closed or is extremely narrow, the accumulation of cations in the vesicle (increased cation concentration) likely leads to lipid demixing at the fusion pore. This process may affect local membrane anisotropy, which reduces the spontaneous curvature and thus leads to the opening of the fusion pore. Based on the theory of membrane elasticity, we used a continuum model to explain the rhythmic opening and closing of the fusion pore.

scholarly journals Excess cholesterol inhibits glucose-stimulated fusion pore dynamics in insulin exocytosis

2017 ◽  
Vol 21 (11) ◽  
pp. 2950-2962 ◽  
Author(s):  
Yingke Xu ◽  
Derek K. Toomre ◽  
Jonathan S. Bogan ◽  
Mingming Hao
Keyword(s):  
Fusion Pore ◽  
Insulin Exocytosis ◽  
Pore Dynamics
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