Absence of Circadian Phase Resetting in Response to Bright Light Behind the Knees

Science ◽  
2002 ◽  
Vol 297 (5581) ◽  
pp. 571-571 ◽  
Author(s):  
K. P. Wright Jr.
Keyword(s):  
Bright Light ◽  
Phase Resetting ◽  
Circadian Phase

Circadian Phase Resetting in Older People by Ocular Bright Light Exposure

2001 ◽  
Vol 49 (1) ◽  
pp. 30-40 ◽  
Author(s):  
E.B. Klerman ◽  
J.F. Duffy ◽  
D.-J. Dijk ◽  
C.A. Czeisler
Keyword(s):  
Older People ◽  
Light Exposure ◽  
Bright Light ◽  
Phase Resetting ◽  
Circadian Phase ◽  
Bright Light Exposure

Photic and nonphotic circadian phase resetting in a diurnal primate, the common marmoset

2001 ◽  
Vol 280 (1) ◽  
pp. R191-R197 ◽  
Author(s):  
J. David Glass ◽  
Suzette D. Tardif ◽  
Robert Clements ◽  
N. Mrosovsky
Keyword(s):  
Phase Angle ◽  
Bright Light ◽  
Common Marmoset ◽  
Phase Resetting ◽  
Behavioral Arousal ◽  
Response Curves ◽  
Common Marmosets ◽  
Circadian Phase ◽  
Circadian Time ◽  
Behavioral Phase

Despite the considerable literature on circadian entrainment, there is little information on this subject in diurnal mammals. Contributing to this lack of understanding is the problem of separating photic from nonphotic (behavioral) phase-resetting events in diurnal species. In the present study, photic phase resetting was obtained in diurnal common marmosets held under constant dim light (DimDim; <0.5 lx) by using a 20-s pulse of bright light to minimize time available for behavioral arousal. This stimulus elicited phase advances at circadian time (CT) 18–22 and phase delays at CT9–12. Daily presentation of these 20-s pulses produced entrainment with a phase angle of ∼11 h (0 h = activity onset). Nonphotic phase resetting was obtained under DimDim with the use of a 1-h-induced activity pulse, consisting of intermittent cage agitation and water sprinkling, delivered in total darkness to minimize photic effects. This stimulus caused phase delays at CT20–24, and entrainment to a scheduled daily regimen of these pulses occurred with a phase angle of ∼0 h. These results indicate that photic and nonphotic phase-response curves (PRCs) of marmosets are similar to those of nocturnal rodents and that nonphotic PRCs are keyed to the phase of the suprachiasmatic nucleus pacemaker, not to the phase of the activity-rest cycle.

Morning bright light therapy: a helpful tool for reducing comorbid symptoms of affective and behavioral dysregulation in juvenile depressed inpatients? A pilot trial

2017 ◽  
Vol 45 (1) ◽  
pp. 34-41 ◽  
Author(s):  
Sarah Bogen ◽  
Tanja Legenbauer ◽  
Stephanie Gest ◽  
Martin Holtmann
Keyword(s):  
Pilot Trial ◽  
Secondary Analysis ◽  
Bright Light ◽  
Light Therapy ◽  
Bright Light Therapy ◽  
Circadian Phase ◽  
Behavioral Dysregulation ◽  
Sleep Parameters ◽  
Circadian Effect ◽  
Dysregulation Profile

Abstract. Objective: In recent years, bright light therapy (BLT) has been used to treat depression and to stabilize circadian rhythms. In this study we evaluated whether it is also helpful for comorbid symptoms of affective and behavioral dysregulation in depressive inpatients. Method: This article reports a secondary analysis comparing two subgroups of depressive participants with comorbid affective and behavioral dysregulation, captured with the dysregulation-profile of the Strengths and Difficulties Questionnaire (SDQ-DP; n = 16 vs. n = 11). Participants were randomly allocated to active BLT (10,000 lux) or control BLT (approx. 100 lux), and received 45 minutes of BLT for 2 weeks. SDQ-DP scores, sleep parameters, and circadian preference were assessed at baseline, after the intervention, and 3 weeks later. Results: No direct effects on SDQ-DP scores were observed. Sleep improved in both conditions. Only in the active BLT condition was a circadian phase advance found. Correlation and regression analyses indicated an indirect, circadian effect for improved SDQ-DP scores. Conclusions: The data of this pilot trial should be considered preliminary and merely descriptive. Further research is warranted.


Enhanced circadian phase resetting in R192Q Cav2.1 calcium channel migraine mice

2008 ◽  
Vol 64 (3) ◽  
pp. 315-324 ◽  
Author(s):  
Floor van Oosterhout ◽  
Stephan Michel ◽  
Tom Deboer ◽  
Thijs Houben ◽  
Rob C. G. van de Ven ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Phase Resetting ◽  
Circadian Phase

scholarly journals A single dose of alcohol does not meaningfully alter circadian phase advances and phase delays to light in humans

2016 ◽  
Vol 310 (8) ◽  
pp. R759-R765 ◽  
Author(s):  
Helen J. Burgess ◽  
Muneer Rizvydeen ◽  
Louis F. Fogg ◽  
Ali Keshavarzian
Keyword(s):  
Single Dose ◽  
Light Pulse ◽  
Bright Light ◽  
Phase Shifts ◽  
Final Phase ◽  
Circadian Timing ◽  
Circadian Phase ◽  
Sleep Episode ◽  
Late Night ◽  
Laboratory Session

Central circadian timing influences mental and physical health. Research in nocturnal rodents has demonstrated that when alcohol is consumed, it reaches the central hypothalamic circadian pacemaker (suprachiasmatic nuclei) and can directly alter circadian phase shifts to light. In two separate studies, we examined, for the first time, the effects of a single dose of alcohol on circadian phase advances and phase delays to light in humans. Two 23-day within-subjects placebo-controlled counterbalanced design studies were conducted. Both studies consisted of 6 days of fixed baseline sleep to stabilize circadian timing, a 2-day laboratory session, a 6-day break, and a repeat of 6 days of fixed sleep and a 2-day laboratory session. In the phase advance study ( n = 10 light drinkers, 24–45 yr), the laboratory sessions consisted of a baseline dim light phase assessment, sleep episode, alcohol (0.6 g/kg) or placebo, 2-h morning bright light pulse, and final phase assessment. In the phase-delay study ( n = 14 light drinkers, 22–44 yr), the laboratory sessions consisted of a baseline phase assessment, alcohol (0.8 g/kg) or placebo, 2-h late night bright light pulse, sleep episode, and final phase assessment. In both studies, alcohol either increased or decreased the observed phase shifts to light (interaction P ≥ 0.46), but the effect of alcohol vs. placebo on phase shifts to light was always on average smaller than 30 min. Thus, no meaningful effects of a single dose of alcohol vs. placebo on circadian phase shifts to light in humans were observed.

Light and Sleep

2021 ◽  
pp. 101-112
Author(s):  
Morgan P. Reid ◽  
Natalie D. Dautovich ◽  
Joseph M. Dzierzewski
Keyword(s):  
Mental Health ◽  
Circadian Rhythm ◽  
Health Outcomes ◽  
Bright Light ◽  
Light Pollution ◽  
Poor Sleep ◽  
Appropriate Use ◽  
Sleep Period ◽  
Circadian Phase ◽  
Environmental Light

Sleep has been consistently demonstrated as a key component of overall health, and poor sleep is associated with various negative physical, cognitive, and mental health outcomes. Optimal sleep requires the sleep–wake circadian rhythm to be synchronized to a 24-hour period. Light is a key determinant in the synchronization of the circadian rhythm to this period. Exposure to bright light in the morning can advance the sleep period, while bright light in the evening can delay the sleep period and lead to negative sleep outcomes. The home environment should make appropriate use of light so as to optimize sleep and eliminate environmental light pollution. Light can also be utilized to treat circadian phase sleep disorders.

Contemporaneous melatonin administration modifies the circadian response to nocturnal bright light stimuli

1997 ◽  
Vol 272 (2) ◽  
pp. R482-R486 ◽  
Author(s):  
A. Cagnacci ◽  
R. Soldani ◽  
S. S. Yen
Keyword(s):  
Light Exposure ◽  
Light Stimulus ◽  
Core Body Temperature ◽  
Bright Light ◽  
Phase Shifts ◽  
Double Blind ◽  
Circadian Phase ◽  
Melatonin Administration ◽  
Baseline Evaluation ◽  
Light Stimuli

We investigated whether the contemporaneous administration of melatonin can modify circadian phase shifts induced by bright light stimuli. After a baseline evaluation, 10 women were exposed for three consecutive nights to a 4-h bright light stimulus (>3,000 lx) initiated at the time of the estimated core body temperature (BT(c)) nadir. Along with light, each woman orally received, randomly and in a double-blind fashion, placebo (n = 5) or melatonin (n = 5; 1 mg 30 min before and 0.75 mg 120 min after the start of light exposure). Daily rhythms were reevaluated at the end of treatment. Bright light phase advanced, by about 90-120 min, BT(c) (P < 0.01), cortisol (P < 0.05), and melatonin (P < 0.01) rhythms. Contemporaneous administration of melatonin antagonized the phase advances of the cortisol and BT(c) rhythms, as well as the melatonin peak and melatonin offset. The phase advance of the melatonin onset was instead enhanced (P < 0.05). Contemporaneous melatonin administration modifies the capability of light to induce circadian phase shifts.

Short-term exposure to constant light promotes strong circadian phase-resetting responses to nonphotic stimuli in Syrian hamsters

2004 ◽  
Vol 19 (10) ◽  
pp. 2779-2790 ◽  
Author(s):  
Megan E. Knoch ◽  
Sharon M. H. Gobes ◽  
Ivanda Pavlovska ◽  
Cathy Su ◽  
Ralph E. Mistlberger ◽  
...  
Keyword(s):  
Constant Light ◽  
Phase Resetting ◽  
Short Term ◽  
Syrian Hamsters ◽  
Circadian Phase ◽  
Short Term Exposure

Circadian Phase Resetting in Response to Light-Dark and Dark-Light Transitions

2008 ◽  
Vol 23 (5) ◽  
pp. 425-434 ◽  
Author(s):  
M. Comas ◽  
D.G.M. Beersma ◽  
R.A. Hut ◽  
S. Daan
Keyword(s):  
Phase Resetting ◽  
Dark Light ◽  
Circadian Phase
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