scholarly journals Integrated immunovirological profiling validates plasma SARS-CoV-2 RNA as an early predictor of COVID-19 mortality

2021 ◽  
Vol 7 (48) ◽  
Author(s):  
Elsa Brunet-Ratnasingham ◽  
Sai Priya Anand ◽  
Pierre Gantner ◽  
Alina Dyachenko ◽  
Gaël Moquin-Beaudry ◽  
...  
Keyword(s):  
Early Predictor

scholarly journals Soluble fms-like tyrosine kinase-1: a potential early predictor of respiratory failure in COVID-19 patients

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
José L. Eguiburu-Jaime ◽  
Aitor Delmiro ◽  
Antonio Lalueza ◽  
Pedro L. Valenzuela ◽  
José M. Aguado ◽  
...  
Keyword(s):  
Respiratory Failure ◽  
Tyrosine Kinase ◽  
Early Predictor

scholarly journals Growth differentiation factor 15 and early prognosis after out-of-hospital cardiac arrest

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Ferran Rueda ◽  
Germán Cediel ◽  
Cosme García-García ◽  
Júlia Aranyó ◽  
Marta González-Lopera ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Tissue Injury ◽  
Cerebral Performance Category ◽  
Neurologic Outcome ◽  
Home Setting ◽  
Growth Differentiation Factor 15 ◽  
Poor Outcome ◽  
Differentiation Factor ◽  
Hospital Cardiac Arrest ◽  
Early Predictor

Abstract Background Growth differentiation factor 15 (GDF-15) is an inflammatory cytokine released in response to tissue injury. It has prognostic value in cardiovascular diseases and other acute and chronic conditions. Here, we explored the value of GDF-15 as an early predictor of neurologic outcome after an out-of-hospital cardiac arrest (OHCA). Methods Prospective registry study of patients in coma after an OHCA, admitted in the intensive cardiac care unit from a single university center. Serum levels of GDF-15 were measured on admission. Neurologic status was evaluated according to the cerebral performance category (CPC) scale. The relationship between GDF-15 levels and poor neurologic outcome at 6 months was analyzed. Results Among 62 patients included, 32 (51.6%) presented poor outcome (CPC 3–5). Patients with CPC 3–5 exhibited significantly higher GDF-15 levels (median, 17.1 [IQR, 11.1–20.4] ng/mL) compared to those with CPC 1–2 (7.6 [IQR, 4.1–13.1] ng/mL; p = 0.004). Multivariable logistic regression analyses showed that age (OR, 1.09; 95% CI 1.01–1.17; p = 0.020), home setting arrest (OR, 8.07; 95% CI 1.61–40.42; p = 0.011), no bystander cardiopulmonary resuscitation (OR, 7.91; 95% CI 1.84–34.01; p = 0.005), and GDF-15 levels (OR, 3.74; 95% CI 1.32–10.60; p = 0.013) were independent predictors of poor outcome. The addition of GDF-15 in a dichotomous manner (≥ 10.8 vs. < 10.8 ng/mL) to the resulting clinical model improved discrimination; it increased the area under the curve from 0.867 to 0.917, and the associated continuous net reclassification improvement was 0.90 (95% CI 0.48–1.44), which allowed reclassification of 37.1% of patients. Conclusions After an OHCA, increased GDF-15 levels were an independent, early predictor of poor neurologic outcome. Furthermore, when added to the most common clinical factors, GDF-15 improved discrimination and allowed patient reclassification.

scholarly journals Early Post-Operative Pancreatitis and Systemic Inflammatory Response Assessed by Serum Lipase and IL-6 Predict Pancreatic Fistula

2020 ◽  
Vol 44 (12) ◽  
pp. 4236-4244
Author(s):  
S. Gasteiger ◽  
F. Primavesi ◽  
G. Göbel ◽  
E. Braunwarth ◽  
B. Cardini ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Pancreatic Fistula ◽  
Pancreatic Resection ◽  
Roc Analysis ◽  
Youden Index ◽  
Clinical Trial Registration ◽  
Serum Lipase ◽  
Mortality And Morbidity ◽  
Prospective Pilot Study ◽  
Early Predictor

Abstract Background Post-operative pancreatic fistula (POPF) remains a critical complication after pancreatic resection. This prospective pilot study evaluates perioperative markers of pancreatitis and systemic inflammation to predict clinically relevant grade B/C-POPF (CR-POPF). Methods All patients undergoing pancreatic resection from December 2017 to April 2019 were prospectively enrolled. Surgical procedures and outcomes were correlated with perioperative blood markers. ROC analysis was performed to assess their predictive value for CR-POPF. Cut-offs were calculated with the Youden index. Results In total, 70 patients were analysed (43 pancreatoduodenectomies and 27 distal pancreatectomies). In-hospital/90-d mortality and morbidity were 5.7/7.1% (n = 4/n = 5) and 75.7% (n = 53). Major complications (Clavien–Dindo ≥ 3a) occurred in 28 (40.0%) patients, CR-POPF in 20 (28.6%) patients. Serum lipase (cut-off > 51U/L) and IL-6 (> 56.5 ng/l) on POD3 were significant predictors for CR-POPF (AUC = 0.799, 95%-CI 0.686–0.912 and AUC = 0.784, 95%-CI 0.668–0.900; combined AUC = 0.858, 95%-CI 0.758–0.958; all p < 0.001). Patients with both or one factor(s) above cut-off more frequently developed CR-POPF than cases without (100 vs. 50% vs. 7.5%, p < 0.001). This also applied for overall and severe complications (p = 0.013 and p = 0.009). Conclusions Post-operative pancreatitis and inflammatory response are major determinants for development of POPF. A combination of serum lipase and IL-6 on POD3 is a highly significant early predictor of CR-POPF and overall complications, potentially guiding patient management. Clinical trial registration The study protocol was registered at clinicaltrials.gov (NCT04294797)

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