scholarly journals Synaptic vesicle pools are a major hidden resting metabolic burden of nerve terminals

2021 ◽  
Vol 7 (49) ◽  
Author(s):  
Camila Pulido ◽  
Timothy A. Ryan
Keyword(s):  
Synaptic Vesicle ◽  
Nerve Terminals ◽  
Metabolic Burden ◽  
Vesicle Pools

scholarly journals Synaptic vesicle pools are a major hidden resting metabolic burden of nerve terminals

2020 ◽  
Author(s):  
Camila Pulido ◽  
Timothy Aidan Ryan
Keyword(s):  
Cognitive Impairment ◽  
Steady State ◽  
Energy Consumption ◽  
Human Brain ◽  
Synaptic Vesicle ◽  
Atp Synthesis ◽  
Nerve Terminals ◽  
Metabolic Rates ◽  
On Demand ◽  
Vesicle Pools

The human brain is a uniquely vulnerable organ as interruption in fuel supply leads to acute cognitive impairment on rapid time scales. The reasons for this vulnerability are not well understood, but nerve terminals are likely loci of this vulnerability as they do not store sufficient ATP molecules and must synthesize them on-demand during activity or suffer acute degradation in performance. The requirements for on-demand ATP synthesis however depends in part on the magnitude of resting metabolic rates. We show here that, at rest, synaptic vesicle (SV) pools are a major source of presynaptic basal energy consumption. This basal metabolism arises from SV-resident V-ATPases compensating for a hidden resting H+ efflux from the SV lumen. We show that this steady-state H+ efflux is 1) mediated by vesicular neurotransmitter transporters, 2) independent of the SV cycle, 3) accounts for ~half of the resting synaptic energy consumption and 4) contributes to nerve terminal intolerance of fuel deprivation.

scholarly journals Properties of Synaptic Vesicle Pools in Mature Central Nerve Terminals

2005 ◽  
Vol 280 (44) ◽  
pp. 37278-37288 ◽  
Author(s):  
Anthony C. Ashton ◽  
Yuri A. Ushkaryov
Keyword(s):  
Synaptic Vesicle ◽  
Nerve Terminals ◽  
Vesicle Pools

Sequential changes in synaptic vesicle pools and endosome-like organelles during depolarization near the active zone of central nerve terminals

Neuroscience ◽  
2002 ◽  
Vol 109 (1) ◽  
pp. 195-206 ◽  
Author(s):  
A.G.M Leenders ◽  
G Scholten ◽  
R.P.J de Lange ◽  
F.H Lopes da Silva ◽  
W.E.J.M Ghijsen
Keyword(s):  
Synaptic Vesicle ◽  
Active Zone ◽  
Nerve Terminals ◽  
Vesicle Pools

scholarly journals A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals.

1996 ◽  
Vol 93 (1) ◽  
pp. 331-335 ◽  
Author(s):  
C. David ◽  
P. S. McPherson ◽  
O. Mundigl ◽  
P. de Camilli
Keyword(s):  
Synaptic Vesicle ◽  
Nerve Terminals
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