scholarly journals Imaging and tracing the pattern of adult ovarian angiogenesis implies a strategy against female reproductive aging

2022 ◽  
Vol 8 (2) ◽  
Author(s):  
Xueqiang Xu ◽  
Lu Mu ◽  
Lingyu Li ◽  
Jing Liang ◽  
Shuo Zhang ◽  
...  
Keyword(s):  
Life Span ◽  
Reproductive Aging ◽  
Unique Model ◽  
Reproductive Life ◽  
Reproductive Life Span

Unique model of adult ovarian angiogenesis implies a strategy to extend female reproductive life span.

Reproductive Uncertainty and the Evolution of Iteroparity: Why Don't Flatfish Put All Their Eggs in One Basket?

1981 ◽  
Vol 38 (8) ◽  
pp. 968-977 ◽  
Author(s):  
Derek A. Roff
Keyword(s):  
Reproductive Success ◽  
Life Span ◽  
Intrinsic Rate ◽  
Intrinsic Rate Of Increase ◽  
Rate Of Increase ◽  
Age Of Maturity ◽  
Reproductive Life ◽  
Reproductive Life Span ◽  
Engraulis Ringens ◽  
Using Data

Murphy's hypothesis that variation in reproductive life span is an adaptive response to variation in the predictability of reproductive success is examined. Murphy's contention that this hypothesis explains the variation in reproductive life span within the clupeids is reexamined incorporating further data on the Peruvian anchovy (Engraulis ringens). A nonsignificant correlation is now obtained between reproductive life span and brood strength variation; thus, the hypothesis is called into question. An alternative explanation is presented that considers the interaction between life history parameters: because it is necessary for the intrinsic rate of increase to exceed zero, variation in one parameter must be associated with variation in at least one other parameter. In the clupeids it is noted that the age of maturity and reproductive life span vary in concert and it is suggested that this provides an explanation of variation in reproductive life span. These two hypotheses are examined using data on the family Pleuronectidae, the flatfish. No correlation exists between reproductive life span and the degree of fluctuation in brood strength but there is a significant correlation between reproductive life span and age of maturity. It is concluded that variation in reproductive life span within the flatfish group is not a response to variation in reproductive success but rather a correlate of variation in age of maturity.Key words: flatfish, Pleuronectidae, iteroparity, natural selection, reproduction, clupeids

scholarly journals Concept of Granthi with reference to uterine fibroid: An Ayurveda review

2021 ◽  
Vol 9 (02) ◽  
Author(s):  
Jaya Umate ◽  
Soudamini Chaudhari
Keyword(s):  
Life Span ◽  
Uterine Fibroid ◽  
Uterine Fibroids ◽  
Modern Science ◽  
Reproductive Age ◽  
Significant Morbidity ◽  
Reproductive Life ◽  
Reproductive Life Span ◽  
Gynecological Disease ◽  
Reproductive Age Group

Uterine fibroids are the commonest benign tumor of the uterus and also the commonest benign solid tumor in the female. It can cause significant morbidity in women of a reproductive life span. The exact cause of uterine fibroid is unknown. Prevalence of uterine fibroid 5 -20 % of women in the reproductive age group. It can cause significant morbidity in women of a reproductive life span. Not all fibroids cause symptoms. 50% of women are asymptomatic. Fibroids mainly cause symptoms like menorrhagia, dysmenorrhea and cause pressure symptoms on adjacent viscera i. e. bladder, uterus, rectum which affects the everyday activities of women. In Ayurveda all gynecological disease explained under the term yonivyapad. It can be explained as the anatomical and functional abnormalities of the female reproductive system. In Ayurveda granthi can be correlated with the uterine fibroid. In modern science uterine fibroid treats medically, surgically. But it is challenging to establish a satisfactory conservatory medical treatment to date. so in Ayurveda the main purpose is the management of granthi by samprapti vighatan by use of medicine.

scholarly journals PohnB6F1: A Cross of Wild and Domestic Mice That Is a New Model of Extended Female Reproductive Life Span

2007 ◽  
Vol 62 (11) ◽  
pp. 1187-1198 ◽  
Author(s):  
K. Flurkey ◽  
Y. Brandvain ◽  
S. Klebanov ◽  
S. N. Austad ◽  
R. A. Miller ◽  
...  
Keyword(s):  
Life Span ◽  
New Model ◽  
Reproductive Life ◽  
Reproductive Life Span

scholarly journals Chromosome errors in human eggs shape natural fertility over reproductive life span

Science ◽  
2019 ◽  
Vol 365 (6460) ◽  
pp. 1466-1469 ◽  
Author(s):  
Jennifer R. Gruhn ◽  
Agata P. Zielinska ◽  
Vallari Shukla ◽  
Robert Blanshard ◽  
Antonio Capalbo ◽  
...  
Keyword(s):  
Life Span ◽  
Chromosome Segregation ◽  
Pregnancy Loss ◽  
Natural Fertility ◽  
Congenital Disorders ◽  
Human Oocytes ◽  
Reproductive Life ◽  
Reproductive Life Span ◽  
Quantitative Explanation ◽  
Chromosome Nondisjunction

Chromosome errors, or aneuploidy, affect an exceptionally high number of human conceptions, causing pregnancy loss and congenital disorders. Here, we have followed chromosome segregation in human oocytes from females aged 9 to 43 years and report that aneuploidy follows a U-curve. Specific segregation error types show different age dependencies, providing a quantitative explanation for the U-curve. Whole-chromosome nondisjunction events are preferentially associated with increased aneuploidy in young girls, whereas centromeric and more extensive cohesion loss limit fertility as women age. Our findings suggest that chromosomal errors originating in oocytes determine the curve of natural fertility in humans.

Post-reproductive life span and demographic stability

Oikos ◽  
2012 ◽  
Vol 121 (9) ◽  
pp. 1370-1378 ◽  
Author(s):  
Josh Mitteldorf ◽  
Charles Goodnight
Keyword(s):  
Life Span ◽  
Reproductive Life ◽  
Reproductive Life Span

Is telomere length one of the determinants of reproductive life span?

2005 ◽  
Vol 272 (2) ◽  
pp. 113-116 ◽  
Author(s):  
Sena E. Aydos ◽  
Atilla H. Elhan ◽  
Ajlan Tükün
Keyword(s):  
Life Span ◽  
Telomere Length ◽  
Reproductive Life ◽  
Reproductive Life Span

scholarly journals GENETIC CORRELATION BETWEEN RESISTANCE TO OXIDATIVE STRESS AND REPRODUCTIVE LIFE SPAN IN A BIRD SPECIES

Evolution ◽  
2010 ◽  
Vol 64 (3) ◽  
pp. 852-857 ◽  
Author(s):  
Sin-Yeon Kim ◽  
Alberto Velando ◽  
Gabriele Sorci ◽  
Carlos Alonso-Alvarez
Keyword(s):  
Oxidative Stress ◽  
Life Span ◽  
Genetic Correlation ◽  
Bird Species ◽  
Reproductive Life ◽  
Reproductive Life Span

scholarly journals Bridge Integrator 2, a New Specific Target for Improving Reproductive Life Span through RPS6 and NNT

2021 ◽  
Author(s):  
Feng-Yu Zhu ◽  
Li-Li Wang ◽  
Tie-Gang Meng ◽  
Zhi-Xia Yang ◽  
Ruo-Lei Wang ◽  
...  
Keyword(s):  
Free Radical ◽  
Side Effects ◽  
Life Span ◽  
Quantitative Proteomics ◽  
Primordial Follicle ◽  
Oocyte Quality ◽  
Specific Target ◽  
Reproductive Life ◽  
Reproductive Life Span ◽  
Female Ovary

Abstract Female ovary is the earliest degenerated organ and it faces distinct medical disadvantages that impair primordial follicle reserve and oocyte quality. Herein, we found that bridge integrator 2 (Bin2) was predominant within mouse ovaries and oocytes, and global-knockout of Bin2 improved both female fertility and oocyte quality with healthy physiology in mice. Ovarian quantitative proteomics and phosphomics showed that Bin2 knockout specifically decreased only p-RPS6 of mTOR pathway; meanwhile, it increased nicotinamide nucleotide transhydrogenase (NNT), the free-radical detoxifier, over 6-fold. Mechanically, phosphorylation at Thr423 & Ser424 translocated membrane Bin2 into cytoplasm to phosphorylate RPS6, while p-RPS6 bound 42-95 bp NNT UTR to inhibit NNT translation. We then synthesized a peptide (BPP) to mimic Bin2 inhibition, and found that 3-week BPP injection improved primordial follicle reserve and oocyte quality in aging or chemotherapeutics-treated mice. In all, Bin2 inhibition improve both primordial follicle reserve and oocyte quality without discernible side effects.

Sign in / Sign up

Export Citation Format

Share Document