scholarly journals A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance

2021 ◽  
Vol 7 (39) ◽  
Author(s):  
Giulia Rossetti ◽  
Judith A. Ermer ◽  
Maike Stentenbach ◽  
Stefan J. Siira ◽  
Tara R. Richman ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Rna Processing ◽  
Genetic Variant ◽  
Mitochondrial Rna ◽  
Common Genetic Variant ◽  
Processing Enzyme

scholarly journals Saccharomyces cerevisiae contains an RNase MRP that cleaves at a conserved mitochondrial RNA sequence implicated in replication priming.

1992 ◽  
Vol 12 (6) ◽  
pp. 2561-2569 ◽  
Author(s):  
L L Stohl ◽  
D A Clayton
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Mitochondrial Dna ◽  
Dna Replication ◽  
Rna Processing ◽  
Mitochondrial Rna ◽  
Rna Sequence ◽  
Rnase Mrp ◽  
Processing Activity ◽  
Yeast Mitochondrial Dna ◽  
Human And Mouse

Yeast mitochondrial DNA contains multiple promoters that sponsor different levels of transcription. Several promoters are individually located immediately adjacent to presumed origins of replication and have been suggested to play a role in priming of DNA replication. Although yeast mitochondrial DNA replication origins have not been extensively characterized at the primary sequence level, a common feature of these putative origins is the occurrence of a short guanosine-rich region in the priming strand downstream of the transcriptional start site. This situation is reminiscent of vertebrate mitochondrial DNA origins and raises the possibility of common features of origin function. In the case of human and mouse cells, there exists an RNA processing activity with the capacity to cleave at a guanosine-rich mitochondrial RNA sequence at an origin; we therefore sought the existence of a yeast endoribonuclease that had such a specificity. Whole cell and mitochondrial extracts of Saccharomyces cerevisiae contain an RNase that cleaves yeast mitochondrial RNA in a site-specific manner similar to that of the human and mouse RNA processing activity RNase MRP. The exact location of cleavage within yeast mitochondrial RNA corresponds to a mapped site of transition from RNA to DNA synthesis. The yeast activity also cleaved mammalian mitochondrial RNA in a fashion similar to that of the mammalian RNase MRPs. The yeast endonuclease is a ribonucleoprotein, as judged by its sensitivity to nucleases and proteinase, and it was present in yeast strains lacking mitochondrial DNA, which demonstrated that all components required for in vitro cleavage are encoded by nuclear genes. We conclude that this RNase is the yeast RNase MRP.

scholarly journals Common genetic variant rs3802842 in 11q23 contributes to colorectal cancer risk in Chinese population

Oncotarget ◽  
2017 ◽  
Vol 8 (42) ◽  
pp. 72227-72234
Author(s):  
Chunze Zhang ◽  
Xichuan Li ◽  
Weihua Zhang ◽  
Yijia Wang ◽  
Guanwei Fan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Chinese Population ◽  
Genetic Variant ◽  
Colorectal Cancer Risk ◽  
Common Genetic Variant
Sign in / Sign up

Export Citation Format

Share Document