scholarly journals Interferon b drives intestinal regeneration after radiation

2021 ◽  
Vol 7 (41) ◽  
Author(s):  
Brian J. Leibowitz ◽  
Guangyi Zhao ◽  
Liang Wei ◽  
Hang Ruan ◽  
Michael Epperly ◽  
...  
Keyword(s):  
Intestinal Regeneration

scholarly journals Remodelling of oxygen-transporting tracheoles drives intestinal regeneration and tumorigenesis in Drosophila

2021 ◽  
Author(s):  
Vasilia Tamamouna ◽  
M. Mahidur Rahman ◽  
Monika Petersson ◽  
Irini Charalambous ◽  
Kristina Kux ◽  
...  
Keyword(s):  
Intestinal Regeneration

scholarly journals Antibiotics Modulate Intestinal Regeneration

Biology ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 236
Author(s):  
Lymarie M. Díaz-Díaz ◽  
Natalia Rosario-Meléndez ◽  
Andrea Rodríguez-Villafañe ◽  
Yariel Y. Figueroa-Vega ◽  
Omar A. Pérez-Villafañe ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Sea Cucumber ◽  
Regenerative Processes ◽  
Ecm Remodeling ◽  
Bacterial Cultures ◽  
Intestinal Regeneration ◽  
Negative Effect ◽  
Altered Cell ◽  
Holothuria Glaberrima ◽  
Mtt Assays

The increased antibiotics usage in biomedical and agricultural settings has been well documented. Antibiotics have now been shown to exert effects outside their purposive use, including effects on physiological and developmental processes. We explored the effect of various antibiotics on intestinal regeneration in the sea cucumber Holothuria glaberrima. For this, holothurians were eviscerated and left to regenerate for 10 days in seawater with different penicillin/streptomycin-based cocktails (100 µg/mL PS) including: 100 µg/mL kanamycin (KPS), 5 µg/mL vancomycin (VPS), and 4 µg/mL (E4PS) or 20 µg/mL (E20PS) erythromycin. Immunohistological and histochemical analyses were performed to analyze regenerative processes, including rudiment size, extracellular matrix (ECM) remodeling, cell proliferation, and muscle dedifferentiation. A reduction in muscle dedifferentiation was observed in all antibiotic-treated animals. ECM remodeling was decreased by VPS, E4PS, and E20PS treatments. In addition, organisms subjected to E20PS displayed a significant reduction in the size of their regenerating rudiments while VPS exposure altered cell proliferation. MTT assays were used to discard the possibility that the antibiotics directly affect holothurian metabolic activity while bacterial cultures were used to test antibiotic effects on holothurian enteric microbiota. Our results demonstrate a negative effect on intestinal regeneration and strongly suggest that these effects are due to alterations in the microbial community.

Sa1372 Dormant ISCs Contribute to Intestinal Regeneration After Inflammation

2016 ◽  
Vol 150 (4) ◽  
pp. S298
Author(s):  
Camilla Richmond ◽  
Hannah Rickner ◽  
Manasvi Shah ◽  
Alessio Tovaglieri ◽  
Luke Deary ◽  
...  
Keyword(s):  
Intestinal Regeneration

Intestinal Regeneration and Adaptation Models

2001 ◽  
pp. 557-571 ◽  
Author(s):  
Sonia Y. Archer ◽  
Richard A. Hodin
Keyword(s):  
Intestinal Regeneration
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