scholarly journals Microglial dyshomeostasis drives perineuronal net and synaptic loss in a CSF1R +/− mouse model of ALSP, which can be rescued via CSF1R inhibitors

2021 ◽  
Vol 7 (35) ◽  
Author(s):  
Miguel A. Arreola ◽  
Neelakshi Soni ◽  
Joshua D. Crapser ◽  
Lindsay A. Hohsfield ◽  
Monica R. P. Elmore ◽  
...  
Keyword(s):  
Mouse Model ◽  
Perineuronal Net ◽  
Synaptic Loss

scholarly journals Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model

2016 ◽  
Vol 36 (1) ◽  
pp. 125-141 ◽  
Author(s):  
J. Wu ◽  
D. A. Ryskamp ◽  
X. Liang ◽  
P. Egorova ◽  
O. Zakharova ◽  
...  
Keyword(s):  
Mouse Model ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Calcium Entry ◽  
Synaptic Loss ◽  
Store Operated Calcium Entry

scholarly journals Ouabain-Induced Cochlear Nerve Degeneration: Synaptic Loss and Plasticity in a Mouse Model of Auditory Neuropathy

2013 ◽  
Vol 15 (1) ◽  
pp. 31-43 ◽  
Author(s):  
Yasheng Yuan ◽  
Fuxin Shi ◽  
Yanbo Yin ◽  
Mingjie Tong ◽  
Hainan Lang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Auditory Neuropathy ◽  
Cochlear Nerve ◽  
Nerve Degeneration ◽  
Synaptic Loss

scholarly journals Oridonin Attenuates Synaptic Loss and Cognitive Deficits in an Aβ1–42-Induced Mouse Model of Alzheimer’s Disease

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0151397 ◽  
Author(s):  
Sulei Wang ◽  
Linjie Yu ◽  
Hui Yang ◽  
Chaosheng Li ◽  
Zhen Hui ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Cognitive Deficits ◽  
Synaptic Loss ◽  
Model Of Alzheimer’S Disease

scholarly journals Progressive Neuronal Pathology and Synaptic Loss Induced by Prediabetes and Type 2 Diabetes in a Mouse Model of Alzheimer’s Disease

2016 ◽  
Vol 54 (5) ◽  
pp. 3428-3438 ◽  
Author(s):  
Juan Jose Ramos-Rodriguez ◽  
Tara Spires-Jones ◽  
Amy M. Pooler ◽  
Alfonso Maria Lechuga-Sancho ◽  
Brian J. Bacskai ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Type 2 Diabetes ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Synaptic Loss ◽  
Model Of Alzheimer’S Disease ◽  
Neuronal Pathology

scholarly journals 7,8-Dihydroxyflavone Prevents Synaptic Loss and Memory Deficits in a Mouse Model of Alzheimer’s Disease

2013 ◽  
Vol 39 (3) ◽  
pp. 638-650 ◽  
Author(s):  
Zhentao Zhang ◽  
Xia Liu ◽  
Jason P Schroeder ◽  
Chi-Bun Chan ◽  
Mingke Song ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Memory Deficits ◽  
Synaptic Loss ◽  
Model Of Alzheimer’S Disease

scholarly journals Minocycline Alleviates Abnormal Phagocytosis of Synapses by Microglia in a Mouse Model of Depression

2021 ◽  
Author(s):  
Qiu-Qin Han ◽  
Shi-Yu Shen ◽  
Xiao-Rong Chen ◽  
Adam Pilot ◽  
Ling-Feng Liang ◽  
...  
Keyword(s):  
Mouse Model ◽  
Microglial Activation ◽  
Functional Brain Imaging ◽  
Behavioral Impairment ◽  
Synaptic Loss ◽  
Neuronal Synapses ◽  
Pathological Conditions ◽  
Treatment Of Depression ◽  
Novel Drugs

Abstract Background Depression is an affective disorder characterized by low mood and loss of interest. So far, the mechanism of antidepressants commonly used in clinical practice has proved problematic, thus it is urgent to gain an updated understanding of the pathogenesis of depression and find potential therapeutic targets. As both functional brain imaging studies and autopsy reports indicated that there is indeed a loss of synapses in depressed patients, it is necessary to explore the mechanism of this process. Methods We firstly investigated the effect of CSDS (a mouse model of depression) on behaviors, synapses, microglia, and phagocytosis of synapses by microglia in mice. Then, to confirm the role of microglia in depression, we used minocycline, a microglial activation inhibitor, to study its effect on behaviors and phagocytosis of synapses in stressed mice. Results Our results show that the expression levels of PSD-95 in the hippocampus of CSDS-induced depression mice are significantly reduced, while the microglia are significantly activated. We co-labeled the synaptic protein PSD-95 with the microglia marker Iba-1, and found that the microglia in the hippocampus of stressed mice contained significantly more PSD-95 engulfed puncta, which revealed that microglia in stressed mice abnormally phagocytized synapses. Moreover, our results indicated that minocycline treatment dampened microglial activation, reduced synaptic loss, alleviated behavioral impairment, and reduced abnormal phagocytosis of synapses by microglia in stressed mice. Conclusions Under depressive pathological conditions, the activated microglia may abnormally engulf neuronal synapses causing synaptic loss. Our findings are important for the discovery of novel drugs for the treatment of depression.

scholarly journals Lycium barbarum extracts preserve retinal function by rescuing synaptic loss in 3XTG mouse model of Alzheimer’s disease

2020 ◽  
Vol 16 (S9) ◽  
Author(s):  
Jinfeng Liu ◽  
Guoying Xiong ◽  
Youhong Lin ◽  
Raymond Chuen‐Chung Chang ◽  
Kwok‐Fai So ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Retinal Function ◽  
Lycium Barbarum ◽  
Synaptic Loss ◽  
Model Of Alzheimer’S Disease
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