scholarly journals Mga safeguards embryonic stem cells from acquiring extraembryonic endoderm fates

2021 ◽  
Vol 7 (4) ◽  
Author(s):  
Jinzhong Qin ◽  
Congcong Wang ◽  
Yaru Zhu ◽  
Ting Su ◽  
Lixia Dong ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Extraembryonic Endoderm

scholarly journals Derivation of extraembryonic endoderm stem (XEN) cells from mouse embryos and embryonic stem cells

2013 ◽  
Vol 8 (6) ◽  
pp. 1028-1041 ◽  
Author(s):  
Kathy K Niakan ◽  
Nadine Schrode ◽  
Lily T Y Cho ◽  
Anna-Katerina Hadjantonakis
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Mouse Embryos ◽  
Extraembryonic Endoderm

scholarly journals Protein Kinase C Mediated Extraembryonic Endoderm Differentiation of Human Embryonic Stem Cells

Stem Cells ◽  
2012 ◽  
Vol 30 (3) ◽  
pp. 461-470 ◽  
Author(s):  
Xuezhu Feng ◽  
Jiuchun Zhang ◽  
Kimberly Smuga-Otto ◽  
Shulan Tian ◽  
Junying Yu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Protein Kinase C ◽  
Embryonic Stem Cells ◽  
Protein Kinase ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Endoderm Differentiation ◽  
Extraembryonic Endoderm ◽  
Kinase C

Involvement of Ras in extraembryonic endoderm differentiation of embryonic stem cells

2004 ◽  
Vol 313 (3) ◽  
pp. 475-481 ◽  
Author(s):  
Urara Yoshida-Koide ◽  
Takahiko Matsuda ◽  
Kunikazu Saikawa ◽  
Yasuni Nakanuma ◽  
Takashi Yokota ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Endoderm Differentiation ◽  
Extraembryonic Endoderm

scholarly journals Repression by hdac3 and dax1 mediates lineage restriction of embryonic stem cells

2020 ◽  
Author(s):  
Daniel Olivieri ◽  
Panagiotis Papasaikas ◽  
Ilya Lukonin ◽  
Melanie Rittirsch ◽  
Daniel Hess ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Transcriptional Repressors ◽  
Cell Type ◽  
Type Conversion ◽  
Extraembryonic Endoderm ◽  
Early Embryos ◽  
Cell Type Conversion ◽  
3D Spheroids

ABSTRACTMouse embryonic stem cells (mESCs) give rise to embryonic but not extraembryonic endoderm fates. Here, we identify the mechanism of this lineage barrier and report that the histone deacetylase Hdac3 and the corepressor Dax1 cooperatively restrict transdifferentiation of mESCs by silencing an enhancer of the extraembryonic endoderm-specifying transcription factor (TF) Gata6. This restriction is opposed by the pluripotency TFs Nr5a2 and Esrrb, which promote cell type conversion. Perturbation of the barrier extends mESC potency, and allows formation of 3D spheroids that mimic the spatial segregation of embryonic epiblast and extraembryonic endoderm in early embryos. Overall, this study shows that transcriptional repressors stabilize pluripotency by biasing the equilibrium between embryonic and extraembryonic lineages that is hardwired into the mESC TF network.

scholarly journals Identification of an Enhancer That Controls Up-regulation of Fibronectin during Differentiation of Embryonic Stem Cells into Extraembryonic Endoderm

2004 ◽  
Vol 280 (8) ◽  
pp. 7244-7252 ◽  
Author(s):  
Tetsu Shirai ◽  
Satoru Miyagi ◽  
Daisuke Horiuchi ◽  
Tomoko Okuda-Katayanagi ◽  
Masazumi Nishimoto ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Extraembryonic Endoderm
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