scholarly journals Wearable plasmonic-metasurface sensor for noninvasive and universal molecular fingerprint detection on biointerfaces

2021 ◽  
Vol 7 (4) ◽  
pp. eabe4553
Author(s):  
Yingli Wang ◽  
Chen Zhao ◽  
Jingjing Wang ◽  
Xuan Luo ◽  
Lijuan Xie ◽  
...  
Keyword(s):  
Human Health ◽  
The Body ◽  
Molecular Fingerprint ◽  
Wearable Sensing ◽  
Sensing Technology ◽  
Recognition Ability ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Multiple Analytes ◽  
Molecular Tracking

Wearable sensing technology is an essential link to future personalized medicine. However, to obtain a complete picture of human health, it is necessary but challenging to track multiple analytes inside the body simultaneously. Here, we present a wearable plasmonic-electronic sensor with “universal” molecular recognition ability. Flexible plasmonic metasurface with surface-enhanced Raman scattering (SERS)–activity is introduced as the fundamental sensing component in a wearable sensor since we solved the technical challenge of maintaining the plasmonic activities of their brittle nanostructures under various deformations. Together with a flexible electronic sweat extraction system, our sensor can noninvasively extract and “fingerprint” analytes inside the body based on their unique SERS spectra. As a proof-of-concept example, we successfully monitored the variation of trace-amounts drugs inside the body and obtained an individual’s drug metabolic profile. Our sensor bridges the existing gap in wearable sensing technology by providing a universal, sensitive molecular tracking means to assess human health.

Nanomaterial-based SERS sensing technology for biomedical application

2019 ◽  
Vol 7 (24) ◽  
pp. 3755-3774 ◽  
Author(s):  
Zhicheng Huang ◽  
Amin Zhang ◽  
Qian Zhang ◽  
Daxiang Cui
Keyword(s):  
Biomedical Application ◽  
Experimental Studies ◽  
Exciting Field ◽  
Sensing Technology ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Sers Detection ◽  
Enhanced Raman Scattering ◽  
And Function ◽  
Sers Sensing

Over the past few years, nanomaterial-based surface-enhanced Raman scattering (SERS) detection has emerged as a new exciting field in which theoretical and experimental studies of the structure and function of nanomaterials have become a focus.

scholarly journals Biomarkers Determination Based on Surface-Enhanced Raman Scattering

Chemosensors ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 118
Author(s):  
Chao Song ◽  
Shuang Guo ◽  
Sila Jin ◽  
Lei Chen ◽  
Young Mee Jung
Keyword(s):  
Raman Scattering ◽  
New Technologies ◽  
Tissue Injury ◽  
Cell Activity ◽  
Surface Enhanced Raman Scattering ◽  
The Body ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

An overview of noteworthy new methods of biomarker determination based on surface-enhanced Raman scattering (SERS) is presented. Biomarkers can be used to identify the occurrence and development of diseases, which furthers the understanding of biological processes in the body. Accurate detection of a disease-specific biomarker is helpful for the identification, early diagnosis and prevention of a disease and for monitoring during treatment. The search for and discovery of valuable biomarkers have become important research hotspots. Different diseases have different biomarkers, some of which are involved in metabolic processes. Therefore, the fingerprint characteristics and band intensities in SERS spectra have been used to identify metabolites and analyze markers. As a promising technique, SERS has been widely used for the quantitative and qualitative determination of different types of biomarkers for different diseases. SERS techniques provide new technologies for the diagnosis of disease-related markers and determining the basis for clinical treatment. Herein, several SERS-based methods with excellent sensitivity and selectivity for the determination of biomarkers for tumors, viruses, Alzheimer’s disease, cardiac muscle tissue injury, and cell activity are highlighted.

scholarly journals Surface-Enhanced Raman Scattering Based-Molecular Encoding with Gold Nanostars for Anticounterfeiting Application

2021 ◽  
Author(s):  
Yifeng Huo ◽  
Samantha Curry ◽  
Andrew Trowbridge ◽  
Xurong Xu ◽  
Chaoyang Jiang
Keyword(s):  
Raman Scattering ◽  
Raman Spectra ◽  
Surface Enhanced Raman Scattering ◽  
Optical Methods ◽  
Molecular Fingerprint ◽  
Gold Nanostars ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

Surface-enhanced Raman scattering (SERS) recently joins other optical methods in making novel anticounterfeiting materials due the fact that abundant molecular fingerprint in the Raman spectra can be less susceptible to...

A magnetic surface enhanced Raman scattering platform performing successive breast cancer exosome isolation and analysis

2021 ◽  
Author(s):  
Guohao Li ◽  
Nanhang Zhu ◽  
Juan Zhou ◽  
Ke Kang ◽  
Xiaoxi Zhou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Raman Scattering ◽  
Human Health ◽  
Rapid Development ◽  
Physiological Role ◽  
Magnetic Surface ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

Abstract: The rapid development of exosome research provides new insights into the physiological role of exosomes and their significant correlation with human health. Although the exosomes derived from tumor sources...

scholarly journals Size-controlled synthesis of cyclodextrin-capped gold nanoparticles for molecular recognition using surface-enhanced Raman scattering

2021 ◽  
Author(s):  
Koichiro Saito ◽  
Keegan McGehee ◽  
Yasuo Norikane
Keyword(s):  
Gold Nanoparticles ◽  
Molecular Recognition ◽  
Plasmon Resonance ◽  
Self Assembly ◽  
Controlled Synthesis ◽  
Surface Enhanced ◽  
Recognition Ability ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Size Controlled

Cyclodextrin (CD)-capped gold nanoparticles (AuNPs) can be applied in sensing, catalysis, and self-assembly processes due to their molecular recognition ability. As plasmon resonance of AuNPs depends on their size, the...

Peak-fitting assisted SERS strategy for accurate discrimination of carboxylic acid enantiomers

2021 ◽  
Author(s):  
Jing Tao ◽  
Dan Li ◽  
Yanyan Guo ◽  
Wei Deng
Keyword(s):  
Carboxylic Acid ◽  
Raman Scattering ◽  
Surface Enhanced Raman Scattering ◽  
Peak Fitting ◽  
Surface Enhanced ◽  
Recognition Ability ◽  
Enantiomeric Recognition ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

A novel peak-fitting assisted surface-enhanced Raman scattering strategy was proposed for discrimination of carboxylic acid enantiomers with enhanced accuracy and exceptionally strong enantiomeric recognition ability.

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