scholarly journals Integrator enforces the fidelity of transcriptional termination at protein-coding genes

2021 ◽  
Vol 7 (45) ◽  
Author(s):  
Lucas Ferreira Dasilva ◽  
Ezra Blumenthal ◽  
Felipe Beckedorff ◽  
Pradeep Reddy Cingaram ◽  
Helena Gomes Dos Santos ◽  
...  
Keyword(s):  
Protein Coding ◽  
Protein Coding Genes ◽  
Transcriptional Termination

scholarly journals A unified allosteric/torpedo mechanism for transcriptional termination on human protein-coding genes

2019 ◽  
Vol 34 (1-2) ◽  
pp. 132-145 ◽  
Author(s):  
Joshua D. Eaton ◽  
Laura Francis ◽  
Lee Davidson ◽  
Steven West
Keyword(s):  
Human Protein ◽  
Protein Coding ◽  
Protein Coding Genes ◽  
Transcriptional Termination

scholarly journals A cis-Tether Terminator, Linc-GmSTT1, Regulates Transcription Termination via the Linc-GmSTT1-intermolecular Interactome in Soybean 

2020 ◽  
Author(s):  
Bo Song ◽  
Tingting Luo ◽  
Ze Pang ◽  
Yuhong Zheng ◽  
Ming Zhao ◽  
...  
Keyword(s):  
Transcription Termination ◽  
Protein Coding ◽  
Α Subunit ◽  
Protein Coding Genes ◽  
Transcriptional Termination ◽  
Non Coding Rna ◽  
Unique Model ◽  
Subunit Expression ◽  
Regulation Function ◽  
Specific Regulation

Abstract Soybean β-conglycinin α-subunit is an important allergen that adversely affects the nutritional and processing qualities of soya products. Although inheritance of the α-subunit and the molecular basis of α-null mutations have been studied intensively, the molecular mechanism that regulates α-subunit expression remains unclear. Here, we demonstrated that a long intergenic non-coding RNA, acting as a soybean cis-tether terminator1 (designated Linc-GmSTT1) regulate β-conglycinin α-subunit expression. The Linc-GmSTT1 was mapped in physical proximity of α-subunit CG-α-1 gene and demonstrated to be a crucial element of the convergent alpha-transcription termination unit (alpha-TTU). Ingeniously, by reading through, Linc-GmSTT1 and CG-α-1 gene co-transcribed and subsequently achieve its Cgy-2-locus (confirm α-normal) specific regulation function via Linc-GmSTT1-intermolcular interactome. This work provides a unique model whereby LincRNA regulated the effective transcriptional termination of proximal protein-coding genes which might be a crucial procession protecting it from the silencing machinery in plant.

scholarly journals Fail-Safe Transcriptional Termination for Protein-Coding Genes in S. cerevisiae

2009 ◽  
Vol 36 (1) ◽  
pp. 88-98 ◽  
Author(s):  
Ana G. Rondón ◽  
Hannah E. Mischo ◽  
Junya Kawauchi ◽  
Nick J. Proudfoot
Keyword(s):  
Protein Coding ◽  
Protein Coding Genes ◽  
Transcriptional Termination ◽  
Fail Safe
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