scholarly journals Atom interferometry with thousand-fold increase in dynamic range

2020 ◽  
Vol 6 (45) ◽  
pp. eabd0650
Author(s):  
Dimitry Yankelev ◽  
Chen Avinadav ◽  
Nir Davidson ◽  
Ofer Firstenberg
Keyword(s):  
Dynamic Range ◽  
Fold Increase ◽  
Atom Interferometry ◽  
Single Shot ◽  
Inertial Forces ◽  
Simultaneous Operation ◽  
Interferometric Sensors ◽  
Maximal Sensitivity ◽  
Order Of Magnitude ◽  
Atom Interferometers

The periodicity inherent to any interferometric signal entails a fundamental trade-off between sensitivity and dynamic range of interferometry-based sensors. Here, we develop a methodology for substantially extending the dynamic range of such sensors without compromising their sensitivity, stability, and bandwidth. The scheme is based on simultaneous operation of two nearly identical interferometers, providing a moiré-like period much larger than 2π and benefiting from close-to-maximal sensitivity and from suppression of common-mode noise. The methodology is highly suited to atom interferometers, which offer record sensitivities in measuring gravito-inertial forces but suffer from limited dynamic range. We experimentally demonstrate an atom interferometer with a dynamic-range enhancement of more than an order of magnitude in a single shot and more than three orders of magnitude within a few shots for both static and dynamic signals. This approach can considerably improve the operation of interferometric sensors in challenging, uncertain, or rapidly varying conditions.

scholarly journals Rapid and site-specific deep phosphoproteome profiling by data-independent acquisition (DIA) without the need for spectral libraries

2019 ◽  
Author(s):  
Dorte B. Bekker-Jensen ◽  
Oliver M. Bernhardt ◽  
Alexander Hogrebe ◽  
Ana Martinez del Val ◽  
Lynn Verbeke ◽  
...  
Keyword(s):  
Kinase Inhibitors ◽  
Dynamic Range ◽  
Phosphorylation Site ◽  
Software Tool ◽  
Single Shot ◽  
Data Independent Acquisition ◽  
Order Of Magnitude ◽  
Site Localization ◽  
Using Data ◽  
Spectral Libraries

ABSTRACTQuantitative phosphoproteomics has in recent years revolutionized understanding of cell signaling, but it remains a challenge to scale the technology for high-throughput analyses. Here we present a rapid and reproducible phosphoproteomics approach to systematically analyze hundreds of samples by fast liquid chromatography tandem mass spectrometry using data independent acquisition (DIA). To overcome the inherent issue of positional phosphopeptide isomers in DIA-based phosphoproteomics, we developed and employed an accurate site localization scoring algorithm, which is incorporated into the Spectronaut software tool. Using a library of synthetic phosphopeptides spiked-in to a yeast phosphoproteome in different ratios we show that it is on par with the top site localization score for data-dependent acquisition (DDA) based phosphoproteomics. Single-shot DIA-based phosphoproteomics achieved an order of magnitude broader dynamic range, higher reproducibility of identification and improved sensitivity and accuracy of quantification compared to state-of-the-art DDA-based phosphoproteomics. Importantly, direct DIA without the need of spectral libraries performed almost on par with analyses using specific project-specific libraries. Moreover, we implemented and benchmarked an algorithm for globally determining phosphorylation site stoichiometry in DIA. Finally, we demonstrate the scalability of the DIA approach by systematically analyzing the effects of thirty different kinase inhibitors in context of epidermal growth factor (EGF) signaling showing that a large proportion of EGF-dependent phospho-regulation is mediated by a specific set of protein kinases.

Quantum sensors for space-borne earth observation

2021 ◽  
Author(s):  
Christian Schubert ◽  
Waldemar Herr ◽  
Holger Ahlers ◽  
Naceur Gaaloul ◽  
Wolfgang Ertmer ◽  
...  
Keyword(s):  
Dynamic Range ◽  
Earth Observation ◽  
Atom Interferometry ◽  
Atom Optics ◽  
Gravity Gradients ◽  
Absolute Measurements ◽  
Vibration Noise ◽  
Atom Interferometers

<p>Atom interferometry enables quantum sensors for absolute measurements of gravity (1) and gravity gradients (2). The combination with classical sensors can be exploited to suppress vibration noise in the interferometer, extend the dynamic range, or to remove the drift from the classical device (3). These features motivate novel sensor and mission concepts for space-borne earth observation e.g. with quantum gradiometers (4) or hybridised atom interferometers (5). We will discuss developments of atom optics and atom interferometry in microgravity in the context of future quantum sensors (6) and outline the perspectives for applications in space (4,5).</p><p>The presented work is supported by by the CRC 1227 DQmat within the projects B07 and B09, the CRC 1464 TerraQ within the projects A01, A02 and A03, by "Niedersächsisches Vorab" through "Förderung von Wissenschaft und Technik in Forschung und Lehre" for the initial funding of research in the new DLR-SI Institute, and through the "Quantum and Nano- Metrology (QUANOMET)" initiative within the project QT3.</p><p>(1) V. Ménoret et al., Scientific Reports 8, 12300, 2018; A. Trimeche et al., Phys. Rev. Appl. 7, 034016, 2017; C. Freier et al., J. of Phys.: Conf. Series 723, 012050, 2016; A. Louchet-Chauvet et al., New J. Phys. 13, 065026, 2011; A. Peters et al., Nature 400, 849, 1999.</p><p>(2) P. Asenbaum et al., Phys. Rev. Lett. 118, 183602, 2017; M. J. Snadden et al., Phys. Rev. Lett. 81, 971, 1998.</p><p>(3) L. Richardson et al., Comm. Phys. 3, 208, 2020; P. Cheiney et al., Phys. Rev. Applied 10, 034030, 2018; J. Lautier et al., Appl. Phys. Lett. 105, 144102, 2014.</p><p>(4) A. Trimeche et al., Class. Quantum Grav. 36, 215004, 2019; K. Douch et al., Adv. Space. Res. 61, 1301, 2018.</p><p>(5) T. Lévèque et al., arXiv:2011.03382; S. Chiow et al., Phys. Rev. A 92, 063613, 2015.</p><p>(6) M. Lachmann et al., arXiv:2101.00972; K. Frye et al., EPJ Quant. Technol. 8, 1, 2021; D. Becker et al., Nature 562, 391, 2018; J. Rudolph et al., New J. Phys. 17, 065001, 2015; H. Müntinga et al., Phys. Rev. Lett. 110, 093602 , 2013.</p>

scholarly journals Differences in Ionic, Enzymatic, and Photosynthetic Features Characterize Distinct Salt Tolerance in Eucalyptus Species

Plants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1401
Author(s):  
Hazar Balti ◽  
Mejda Abassi ◽  
Karl-Josef Dietz ◽  
Vijay Kumar
Keyword(s):  
Dynamic Range ◽  
Hydrolytic Enzymes ◽  
Woody Species ◽  
Photosynthetic Electron Transport ◽  
Fold Increase ◽  
Dose Dependence ◽  
Eucalyptus Species ◽  
Transport Chain ◽  
The Face ◽  
Young Leaves

In the face of rising salinity along coastal regions and in irrigated areas, molecular breeding of tolerant crops and reforestation of exposed areas using tolerant woody species is a two-way strategy. Thus, identification of tolerant plants and of existing tolerance mechanisms are of immense value. In the present study, three Eucalyptus ecotypes with potentially differential salt sensitivity were compared. Soil-grown Eucalyptus plants were exposed to 80 and 170 mM NaCl for 30 days. Besides analysing salt effects on ionic/osmotic balance, and hydrolytic enzymes, plants were compared for dynamics of light-induced redox changes in photosynthetic electron transport chain (pETC) components, namely plastocyanin (PC), photosystem I (PSI) and ferredoxin (Fd), parallel to traditional chlorophyll a fluorescence-based PSII-related parameters. Deconvoluted signals for PC and Fd from PSI allowed identification of PC and PSI as the prime salinity-sensitive components of pETC in tested Eucalyptus species. Eucalyptus loxophleba portrayed efficient K+-Na+ balance (60–90% increased K+) along with a more dynamic range of redox changes for pETC components in old leaves. Young leaves in Eucalyptus loxophleba showed robust endomembrane homeostasis, as underlined by an increased response of hydrolytic enzymes at lower salt concentration (~1.7–2.6-fold increase). Findings are discussed in context of salinity dose dependence among different Eucalyptus species.

Cold atom interferometry for inertial sensing in the field

2020 ◽  
Vol 9 (5) ◽  
pp. 221-225
Author(s):  
Ravi Kumar ◽  
Ana Rakonjac
Keyword(s):  
High Precision ◽  
Cold Atoms ◽  
Cold Atom ◽  
Atom Interferometry ◽  
Precision Measurements ◽  
Inertial Sensing ◽  
Fundamental Physics ◽  
Recent Developments ◽  
Resource Exploration ◽  
Atom Interferometers

AbstractAtom interferometry is one of the most promising technologies for high precision measurements. It has the potential to revolutionise many different sectors, such as navigation and positioning, resource exploration, geophysical studies, and fundamental physics. After decades of research in the field of cold atoms, the technology has reached a stage where commercialisation of cold atom interferometers has become possible. This article describes recent developments, challenges, and prospects for quantum sensors for inertial sensing based on cold atom interferometry techniques.

scholarly journals Nearfield trapping increases lifetime of single-molecule junction by one order of magnitude

2020 ◽  
Author(s):  
Albert C. Aragonès ◽  
Katrin F. Domke
Keyword(s):  
Molecular Electronics ◽  
Single Molecule ◽  
Fold Increase ◽  
Trapping Efficiency ◽  
Non Invasive ◽  
Order Of Magnitude ◽  
Molecule Junction ◽  
Single Molecule Junction ◽  
The Difference ◽  
Power Densities

Abstract Progress in molecular electronics (ME) is largely based on improved understanding of the properties of single molecules (SM) trapped for seconds or longer to enable their detailed characterization. We present a plasmon-supported break-junction (PBJ) platform to significantly increase the lifetime of SM junctions of 1,4-benzendithiol (BDT) without the need for chemical modification of molecule or electrode. Moderate far-field power densities of ca. 11 mW/µm2 lead to a >10-fold increase in minimum lifetime compared to laser-OFF conditions. The nearfield trapping efficiency is twice as large for bridge-site contact compared to hollow-site geometry, which can be attributed to the difference in polarizability. Current measurements and tip-enhanced Raman spectra confirm that native structure and contact geometry of BDT are preserved during the PBJ experiment. By providing a non-invasive pathway to increase short lifetimes of SM junctions, PBJ is a valuable approach for ME, paving the way for improved SM sensing and recognition platforms.

scholarly journals High-dynamic-range imaging for cloud segmentation

2018 ◽  
Vol 11 (4) ◽  
pp. 2041-2049 ◽  
Author(s):  
Soumyabrata Dev ◽  
Florian M. Savoy ◽  
Yee Hui Lee ◽  
Stefan Winkler
Keyword(s):  
Dynamic Range ◽  
High Dynamic Range ◽  
Wide Field ◽  
Single Shot ◽  
Generation Process ◽  
Image Generation ◽  
Large Dynamic Range ◽  
Exposure Fusion ◽  
Wide Field Of View ◽  
High Dynamic

Abstract. Sky–cloud images obtained from ground-based sky cameras are usually captured using a fisheye lens with a wide field of view. However, the sky exhibits a large dynamic range in terms of luminance, more than a conventional camera can capture. It is thus difficult to capture the details of an entire scene with a regular camera in a single shot. In most cases, the circumsolar region is overexposed, and the regions near the horizon are underexposed. This renders cloud segmentation for such images difficult. In this paper, we propose HDRCloudSeg – an effective method for cloud segmentation using high-dynamic-range (HDR) imaging based on multi-exposure fusion. We describe the HDR image generation process and release a new database to the community for benchmarking. Our proposed approach is the first using HDR radiance maps for cloud segmentation and achieves very good results.

Abstract 15240: Evaluation of the Performance and Safety of Wideband Cardiac MRI in Patients With a Cardiac Implantable Electronic Device (CIED)

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Sarah M Schwartz ◽  
Ashitha Pathrose ◽  
Ali Serhal ◽  
Ryan Avery ◽  
Ann Ragin ◽  
...  
Keyword(s):  
Image Quality ◽  
Electronic Device ◽  
Pulse Sequences ◽  
Free Breathing ◽  
Whole Body ◽  
Breath Hold ◽  
Single Shot ◽  
Before And After ◽  
Order Of Magnitude ◽  
Chest X Ray

Introduction: Wideband late gadolinium enhancement (LGE) CMR is capable of suppressing image artifacts induced by cardiac implanted electronic devices (CIEDs). We implemented our own wideband segmented (seg) breath-hold and wideband single-shot (SS) free-breathing LGE pulse sequences and used them clinically since 2016. The purpose of this study was to evaluate image quality and CMR safety of wideband LGE compared to standard LGE. Methods: We retrospectively identified 54 consecutive patients (mean age: 61±15 years; 31% females) with CIED (33 t-ICD, 4 s-ICD, 15 pacemaker, 1 CRT-D, 1 CRT-P) who underwent CMR at 1.5T (Avanto, Siemens). Standard seg, wideband seg, and wideband SS LGE used standard imaging parameters. 16 myocardial segments were scored for scar/myocardial conspicuity and presence of any visual artifact on a 5-point Likert scale (1:worst; 3:acceptable; 5:best). Distance between center of the heart and CIED (CXR D) was measured on chest X-ray. Whole-body specific absorption rate (SAR) was read from DICOM metadata. Device changes were calculated from pre- and post- device interrogation measurements. Results: Both wideband seg and SS LGE consistently produced better image quality than standard LGE (Figure 1A). Median conspicuity and artifact scores were significantly better for wideband seg (F=20.6, p<0.001) and wideband SS (F=24.2, p<0.001) LGE compared to standard LGE. There was a trend in conspicuity and artifact scores with CIED distance for standard LGE (rho=0.476, p=0.02), but not wideband LGE scans (Figure 1B, 1C). Whole-body SAR averaged for both wideband scans (0.15±0.04 W/kg) was one order of magnitude below the 2.0 W/kg FDA limit. Device parameters (sensing, impedance, threshold, battery level) did not differ before and after CMR including wideband LGE. Conclusions: Both wideband seg and SS LGE scans produced improved image quality compared to standard LGE while maintaining CMR safety. *The first two authors (SS and AP) contributed equally

Enhanced-Dynamic-Range Single-Shot Measurement of Nanosecond Optical Pulses Based on Fiber Pulse Replication Loop

2012 ◽  
Vol 39 (4) ◽  
pp. 0408005
Author(s):  
潘雪 Pan Xue ◽  
李学春 Li Xuechun ◽  
李国扬 Li Guoyang ◽  
陈宇 Chen Yu ◽  
王江峰 Wang Jiangfeng ◽  
...  
Keyword(s):  
Dynamic Range ◽  
Single Shot ◽  
Optical Pulses

Basal to Near Hyperemic Pulsatile Flow in a Deployed Coronary Stent

2003 ◽  
Author(s):  
Matthew D. Holcomb ◽  
Steven T. Slusher ◽  
Divakar Rajamohan ◽  
Lloyd H. Back ◽  
Milind Jog ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Fold Increase ◽  
Physiological Effects ◽  
Coronary Artery Segment ◽  
Artery Segment ◽  
Order Of Magnitude ◽  
Flow Through ◽  
Wall Shear ◽  
Hyperemic Flow

The present study focuses on developing basal to near hyperemic flow through the entrance region of a deployed stent in a coronary artery segment. Stents that are presently available in market differ significantly in design. Hence, there is a need to optimize its design such that the magnitude of wall shear stress is within physiologic limit, thus minimizing the patho-physiological effects. For near hyperemic flow, the analysis showed a 20 fold increase in the positive values of wall shear stress at the stent wires exposed to the blood flow. Further, at the void next to the entrance, the wall shear stress was an order of magnitude lower than the values typically observed in similar downstream regions.

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