scholarly journals UFMylation of MRE11 is essential for telomere length maintenance and hematopoietic stem cell survival

2021 ◽  
Vol 7 (39) ◽  
Author(s):  
Lara Lee ◽  
Ana Belen Perez Oliva ◽  
Elena Martinez-Balsalobre ◽  
Dmitri Churikov ◽  
Joshua Peter ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Telomere Length ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Stem Cell Survival

scholarly journals UFMylation of MRE11 is essential for maintenance of telomere length and hematopoietic stem cell survival

2019 ◽  
Author(s):  
Lara Lee ◽  
Ana Belen Perez Oliva ◽  
Dmitri Churikov ◽  
Elena Martinez-Balsalobre ◽  
Joshua Peter ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Telomere Length ◽  
Hematopoietic Stem Cell ◽  
Strand Break ◽  
Telomere Maintenance ◽  
Hematopoietic Stem ◽  
Telomere Protein ◽  
Stem Cell Survival

AbstractGenetic studies using knockout mouse models provide strong evidence for the essential role of the ubiquitin-like protein UFM1 for hematopoiesis, especially erythroid development, yet its biological roles in this process are largely unknown. Here we have identified a UFL1-dependent UFMylation of the MRE11 nuclease on the K281 and K282 residues. We show that Hela cells lacking the specific UFM1 E3 ligase display severe telomere shortening. We further demonstrate either by deleting UFM1 or by mutating MRE11 UFMylation sites that preventing MRE11 UFMylation impacts its interaction with the telomere protein TRF2. However, the MRE11 function in double-strand-break repair remains intact. We validate these results in vivo by showing that Zebrafish knockouts for the genes ufl1 and ufm1 have shorter telomeres in hematopoietic cells. Here we present UFMylation has a new mechanisms of regulation for telomere length maintenance with a role in hematopoiesis.Key pointsModification of MRE11 by UFM1 regulates telomere maintenance and cell death in HSCsScientific categoryUFMylation, telomere maintenance, hematopoietic stem cell survival.

scholarly journals Prostaglandin E2 Increases Hematopoietic Stem Cell Survival and Accelerates Hematopoietic Recovery After Radiation Injury

Stem Cells ◽  
2013 ◽  
Vol 31 (2) ◽  
pp. 372-383 ◽  
Author(s):  
Rebecca L. Porter ◽  
Mary A. Georger ◽  
Olga Bromberg ◽  
Kathleen E. McGrath ◽  
Benjamin J. Frisch ◽  
...  
Keyword(s):  
Stem Cell ◽  
Prostaglandin E2 ◽  
Cell Survival ◽  
Hematopoietic Stem Cell ◽  
Radiation Injury ◽  
Hematopoietic Stem ◽  
Hematopoietic Recovery ◽  
Stem Cell Survival

scholarly journals Pontin is essential for murine hematopoietic stem cell survival

Haematologica ◽  
2012 ◽  
Vol 97 (9) ◽  
pp. 1291-1294 ◽  
Author(s):  
O. Bereshchenko ◽  
E. Mancini ◽  
L. Luciani ◽  
A. Gambardella ◽  
C. Riccardi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Stem Cell Survival ◽  
Murine Hematopoietic Stem Cell

scholarly journals Gata2 −77 enhancer regulates adult hematopoietic stem cell survival

Leukemia ◽  
2020 ◽  
Author(s):  
Xiaona You ◽  
Yuan-I Chang ◽  
Guangyao Kong ◽  
Erik A. Ranheim ◽  
Yun Zhou ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Stem Cell Survival

Bone marrow adipocytes support hematopoietic stem cell survival

2017 ◽  
Vol 233 (2) ◽  
pp. 1500-1511 ◽  
Author(s):  
Domenico Mattiucci ◽  
Giulia Maurizi ◽  
Valerio Izzi ◽  
Lorenzo Cenci ◽  
Marco Ciarlantini ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Cell Survival ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Bone Marrow Adipocytes ◽  
Stem Cell Survival

scholarly journals Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Ekta Khattar ◽  
Kyaw Ze Ya Maung ◽  
Chen Li Chew ◽  
Arkasubhra Ghosh ◽  
Michelle Meng Huang Mok ◽  
...  
Keyword(s):  
Dna Damage ◽  
Stem Cell ◽  
Cell Survival ◽  
Hematopoietic Stem Cell ◽  
Dna Ligase ◽  
Hematopoietic Stem ◽  
Dna Ligase Iv ◽  
Ligase Iv ◽  
Response To Chemotherapy ◽  
Stem Cell Survival

AbstractIncreased levels and non-telomeric roles have been reported for shelterin proteins, including RAP1 in cancers. Herein using Rap1 null mice, we provide the genetic evidence that mammalian Rap1 plays a major role in hematopoietic stem cell survival, oncogenesis and response to chemotherapy. Strikingly, this function of RAP1 is independent of its association with the telomere or with its known partner TRF2. We show that RAP1 interacts with many members of the DNA damage response (DDR) pathway. RAP1 depleted cells show reduced interaction between XRCC4/DNA Ligase IV and DNA-PK, and are impaired in DNA Ligase IV recruitment to damaged chromatin for efficient repair. Consistent with its role in DNA damage repair, RAP1 loss decreases double-strand break repair via NHEJ in vivo, and consequently reduces B cell class switch recombination. Finally, we discover that RAP1 levels are predictive of the success of chemotherapy in breast and colon cancer.

scholarly journals TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration

2019 ◽  
Vol 25 (3) ◽  
pp. 357-372.e7 ◽  
Author(s):  
Masayuki Yamashita ◽  
Emmanuelle Passegué
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Hematopoietic Stem Cell ◽  
Hematopoietic Stem ◽  
Tnf Α ◽  
Stem Cell Survival
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