scholarly journals A fully biodegradable and self-electrified device for neuroregenerative medicine

2020 ◽  
Vol 6 (50) ◽  
pp. eabc6686
Author(s):  
Liu Wang ◽  
Changfeng Lu ◽  
Shuhui Yang ◽  
Pengcheng Sun ◽  
Yu Wang ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Functional Restoration ◽  
Rodent Models ◽  
Severe Injuries ◽  
Galvanic Cells ◽  
Self Powered ◽  
Neuroregenerative Medicine ◽  
Electrical Stimuli

Peripheral nerve regeneration remains one of the greatest challenges in regenerative medicine. Deprivation of sensory and/or motor functions often occurs with severe injuries even treated by the most advanced microsurgical intervention. Although electrical stimulation represents an essential nonpharmacological therapy that proved to be beneficial for nerve regeneration, the postoperative delivery at surgical sites remains daunting. Here, a fully biodegradable, self-electrified, and miniaturized device composed of dissolvable galvanic cells on a biodegradable scaffold is achieved, which can offer both structural guidance and electrical cues for peripheral nerve regeneration. The electroactive device can provide sustained electrical stimuli beyond intraoperative window, which can promote calcium activity, repopulation of Schwann cells, and neurotrophic factors. Successful motor functional recovery is accomplished with the electroactive device in behaving rodent models. The presented materials options and device schemes provide important insights into self-powered electronic medicine that can be critical for various types of tissue regeneration and functional restoration.

scholarly journals Construction of Dual-Biofunctionalized Chitosan/Collagen Scaffolds for Simultaneous Neovascularization and Nerve Regeneration

Research ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-18
Author(s):  
Guicai Li ◽  
Qi Han ◽  
Panjian Lu ◽  
Liling Zhang ◽  
Yuezhou Zhang ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Composite Scaffold ◽  
Peripheral Nerve Regeneration ◽  
Functional Restoration ◽  
Collagen Scaffolds ◽  
Repair Capacity ◽  
Solution Blending ◽  
Biological Performance

Biofunctionalization of artificial nerve implants by incorporation of specific bioactive factors has greatly enhanced the success of grafting procedures for peripheral nerve regeneration. However, most studies on novel biofunctionalized implants have emphasized the promotion of neuronal and axonal repair over vascularization, a process critical for long-term functional restoration. We constructed a dual-biofunctionalized chitosan/collagen composite scaffold with Ile-Lys-Val-Ala-Val (IKVAV) and vascular endothelial growth factor (VEGF) by combining solution blending, in situ lyophilization, and surface biomodification. Immobilization of VEGF and IKVAV on the scaffolds was confirmed both qualitatively by staining and quantitatively by ELISA. Various single- and dual-biofunctionalized scaffolds were compared for the promotion of endothelial cell (EC) and Schwann cell (SC) proliferation as well as the induction of angiogenic and neuroregeneration-associated genes by these cells in culture. The efficacy of these scaffolds for vascularization was evaluated by implantation in chicken embryos, while functional repair capacity in vivo was assessed in rats subjected to a 10 mm sciatic nerve injury. Dual-biofunctionalized scaffolds supported robust EC and SC proliferation and upregulated the expression levels of multiple genes and proteins related to neuroregeneration and vascularization. Dual-biofunctionalized scaffolds demonstrated superior vascularization induction in embryos and greater promotion of vascularization, myelination, and functional recovery in rats. These findings support the clinical potential of VEGF/IKVAV dual-biofunctionalized chitosan/collagen composite scaffolds for facilitating peripheral nerve regeneration, making it an attractive candidate for repairing critical nerve defect. The study may provide a critical experimental and theoretical basis for the development and design of new artificial nerve implants with excellent biological performance.

3D structured self-powered PVDF/PCL scaffolds for peripheral nerve regeneration

Nano Energy ◽  
2020 ◽  
Vol 69 ◽  
pp. 104411 ◽  
Author(s):  
Yuan Cheng ◽  
Yang Xu ◽  
Yun Qian ◽  
Xuan Chen ◽  
Yuanming Ouyang ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Self Powered

scholarly journals Application of Hybrid Electrically Conductive Hydrogels Promotes Peripheral Nerve Regeneration

Gels ◽  
2022 ◽  
Vol 8 (1) ◽  
pp. 41
Author(s):  
Fengshi Zhang ◽  
Meng Zhang ◽  
Songyang Liu ◽  
Ci Li ◽  
Zhentao Ding ◽  
...  
Keyword(s):  
Nervous System ◽  
Peripheral Nerve ◽  
Physical Properties ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Functional Restoration ◽  
Nerve Tissue ◽  
Alternative Methods ◽  
Electrically Conductive ◽  
Conductive Hydrogels

Peripheral nerve injury (PNI) occurs frequently, and the prognosis is unsatisfactory. As the gold standard of treatment, autologous nerve grafting has several disadvantages, such as lack of donors and complications. The use of functional biomaterials to simulate the natural microenvironment of the nervous system and the combination of different biomaterials are considered to be encouraging alternative methods for effective tissue regeneration and functional restoration of injured nerves. Considering the inherent presence of an electric field in the nervous system, electrically conductive biomaterials have been used to promote nerve regeneration. Due to their singular physical properties, hydrogels can provide a three-dimensional hydrated network that can be integrated into diverse sizes and shapes and stimulate the natural functions of nerve tissue. Therefore, conductive hydrogels have become the most effective biological material to simulate human nervous tissue’s biological and electrical characteristics. The principal merits of conductive hydrogels include their physical properties and their electrical peculiarities sufficient to effectively transmit electrical signals to cells. This review summarizes the recent applications of conductive hydrogels to enhance peripheral nerve regeneration.

Modern approaches to peripheral nerve regeneration after injury: the prospects of gene and cell therapy

2017 ◽  
Author(s):  
M. Karagyaur ◽  
P. Makarevich ◽  
E. Shevchenko ◽  
D. Stambolsky ◽  
N. Kalinina ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Gene And Cell Therapy

Oxidized Galectin-1 is an Essential Factor for Peripheral Nerve Regeneration

2005 ◽  
Vol 6 (4) ◽  
pp. 385-394 ◽  
Author(s):  
Hidenori Horie ◽  
Toshihiko Kadoya ◽  
Kazunori Sango ◽  
Mitsuhiro Hasegawa
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Essential Factor

Lumbar Dorsal Root Transection in Adult Mice to Study Peripheral Nerve Regeneration

BIO-PROTOCOL ◽  
2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Hyukmin Kim ◽  
Harun Noristani ◽  
Seung Han ◽  
Young-Jin Son
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Dorsal Root ◽  
Peripheral Nerve Regeneration ◽  
Adult Mice
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