scholarly journals Artificial cells drive neural differentiation

2020 ◽  
Vol 6 (38) ◽  
pp. eabb4920 ◽  
Author(s):  
Ö. Duhan Toparlak ◽  
Jacopo Zasso ◽  
Simone Bridi ◽  
Mauro Dalla Serra ◽  
Paolo Macchi ◽  
...  
Keyword(s):  
Mammalian Cells ◽  
Artificial Cells ◽  
Human Embryonic Kidney Cells ◽  
Drug Delivery Vehicles ◽  
Physiological Conditions ◽  
Therapeutic Molecules ◽  
Delivery Vehicles ◽  
Smart Drug ◽  
Smart Drug Delivery

We report the construction of artificial cells that chemically communicate with mammalian cells under physiological conditions. The artificial cells respond to the presence of a small molecule in the environment by synthesizing and releasing a potent protein signal, brain-derived neurotrophic factor. Genetically controlled artificial cells communicate with engineered human embryonic kidney cells and murine neural stem cells. The data suggest that artificial cells are a versatile chassis for the in situ synthesis and on-demand release of chemical signals that elicit desired phenotypic changes of eukaryotic cells, including neuronal differentiation. In the future, artificial cells could be engineered to go beyond the capabilities of typical smart drug delivery vehicles by synthesizing and delivering specific therapeutic molecules tailored to distinct physiological conditions.

Glutathione responsive polymers and their application in drug delivery systems

2017 ◽  
Vol 8 (1) ◽  
pp. 97-126 ◽  
Author(s):  
John F. Quinn ◽  
Michael R. Whittaker ◽  
Thomas P. Davis
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Research Interest ◽  
Drug Delivery Vehicles ◽  
Responsive Polymers ◽  
Delivery Vehicles ◽  
The Subject ◽  
Smart Drug ◽  
Smart Drug Delivery ◽  
Intense Research

Materials which respond to biological cues are the subject of intense research interest due to their possible application in smart drug delivery vehicles.

PUA/PSS multilayer coated CaCO3 microparticles as smart drug delivery vehicles

2013 ◽  
Vol 33 (7) ◽  
pp. 3745-3752 ◽  
Author(s):  
Chao Du ◽  
Jun Shi ◽  
Jin Shi ◽  
Li Zhang ◽  
Shaokui Cao
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Smart Drug ◽  
Smart Drug Delivery

scholarly journals Delivery of cancer therapies by synthetic and bio-inspired nanovectors

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Tina Briolay ◽  
Tacien Petithomme ◽  
Morgane Fouet ◽  
Nelly Nguyen-Pham ◽  
Christophe Blanquart ◽  
...  
Keyword(s):  
Recent Literature ◽  
Biological Properties ◽  
Engineered Nanoparticles ◽  
Oncolytic Viruses ◽  
Cancer Therapies ◽  
Different Types ◽  
Therapeutic Molecules ◽  
Tumor Specificity ◽  
Smart Drug ◽  
Smart Drug Delivery

Abstract Background As a complement to the clinical development of new anticancer molecules, innovations in therapeutic vectorization aim at solving issues related to tumor specificity and associated toxicities. Nanomedicine is a rapidly evolving field that offers various solutions to increase clinical efficacy and safety. Main Here are presented the recent advances for different types of nanovectors of chemical and biological nature, to identify the best suited for translational research projects. These nanovectors include different types of chemically engineered nanoparticles that now come in many different flavors of ‘smart’ drug delivery systems. Alternatives with enhanced biocompatibility and a better adaptability to new types of therapeutic molecules are the cell-derived extracellular vesicles and micro-organism-derived oncolytic viruses, virus-like particles and bacterial minicells. In the first part of the review, we describe their main physical, chemical and biological properties and their potential for personalized modifications. The second part focuses on presenting the recent literature on the use of the different families of nanovectors to deliver anticancer molecules for chemotherapy, radiotherapy, nucleic acid-based therapy, modulation of the tumor microenvironment and immunotherapy. Conclusion This review will help the readers to better appreciate the complexity of available nanovectors and to identify the most fitting “type” for efficient and specific delivery of diverse anticancer therapies.

In Situ Biomimetic Mineralization on ZIF-8 for Smart Drug Delivery

2020 ◽  
Vol 6 (8) ◽  
pp. 4595-4603 ◽  
Author(s):  
Lingxia Shi ◽  
Jun Wu ◽  
Xinrui Qiao ◽  
Yuan Ha ◽  
Yunpeng Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomimetic Mineralization ◽  
Smart Drug ◽  
Smart Drug Delivery

Efficient drug delivery system for bone repair by tuning the surface of hydroxyapatite particles

RSC Advances ◽  
2016 ◽  
Vol 6 (107) ◽  
pp. 104969-104978 ◽  
Author(s):  
Sobia Tabassum ◽  
Saba Zahid ◽  
Faiza Zarif ◽  
Mazhar Amjad Gilani ◽  
Faisal Manzoor ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Surface Properties ◽  
Functional Groups ◽  
Bone Repair ◽  
Precipitation Method ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Co Precipitation

Efficient drug delivery vehicles, hydroxyapatite modified by carboxylic acids, were prepared by an in situ co-precipitation method. The presence of functional groups and subsequent surface properties of modified HA improved ibuprofen loading and release efficiency.

Gold nanoparticles and gold nanoparticle-conjugates for delivery of therapeutic molecules. Progress and challenges

2014 ◽  
Vol 2 (27) ◽  
pp. 4204-4220 ◽  
Author(s):  
I. Fratoddi ◽  
I. Venditti ◽  
C. Cametti ◽  
M. V. Russo
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Gold Nanoparticle ◽  
Drug Delivery Vehicles ◽  
Selective Targeting ◽  
Therapeutic Molecules ◽  
Delivery Vehicles

Gold nanoparticles and their conjugates as drug delivery vehicles for selective targeting of cancer cells.

scholarly journals Hyaluronic Acid/Polylysine Composites for Local Drug Delivery: A Review

2020 ◽  
Vol 850 ◽  
pp. 213-218
Author(s):  
Elīza Tračuma ◽  
Dagnija Loca
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Local Drug Delivery ◽  
Gene Engineering ◽  
Drug Delivery Vehicles ◽  
Bilayer Films ◽  
Delivery Vehicles ◽  
Smart Drug

Site specific drug delivery systems (DDS) are usually developed to overcome the side effects of conventional ones (e.g. injections or oral ingestions), creating smart drug delivery vehicles characterized with greater efficiency, safety, predictable therapeutic response as well as controlled and prolonged drug release periods. DDS made of hyaluronic acid (HA) and poly-L-lysine (PLL) are promising candidates in the field of local drug delivery due to their high biocompatibility. Moreover, electrostatic attractions between negatively charged HA and positively charged PLL can be used to fabricate multilayer films, bilayer films and hydrogels, avoiding the application of toxic crosslinking agents. In this review, we report the preparation of HA/PLL composites exploiting their intrinsic properties, as well as developed composite application possibilities as controlled drug delivery systems in bone tissue, central nervous system and gene engineering.

Medical Applications of Fermentation Technology

2013 ◽  
Vol 810 ◽  
pp. 127-157 ◽  
Author(s):  
Mahbuba Rahman
Keyword(s):  
Mammalian Cells ◽  
Industrial Process ◽  
Batch Mode ◽  
Fermentation Products ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Targeted Drug Discovery ◽  
New Generation ◽  
Anaerobic Conversion ◽  
Fermentation Technology

Fermentation, a process traditionally known for the anaerobic conversion of sugar to carbon dioxide and alcohol by yeast, now refers to an industrial process of manufacturing a wide variety of metabolites and biomaterials by using microorganisms or mammalian cells in a controlled culture environment. Fermentation can be performed in batch mode, continuous mode or in a combinatory, fed-batch mode, depending on the product of interest. Fermentation technology has long been known for the production of various medically important products such as antibiotics, solvents such as ethanol, intermediary compounds such as citric acid, probiotics such as yoghurt etc. New generation fermentation products include anti-viral drugs, therapeutic recombinant proteins and DNA, and monoclonal antibodies. Apart from the drugs, fermentation is also used for the commercial production of materials required for the development of diagnostic kits, drug delivery vehicles and medical devices. Fermentation technology remains at the heart of rapidly growing biopharmaceutical industry today, which is expected to expand even more in the days ahead, in parallel with the progress in novel, targeted drug discovery.

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