scholarly journals Targeted gene silencing in vivo by platelet membrane–coated metal-organic framework nanoparticles

2020 ◽  
Vol 6 (13) ◽  
pp. eaaz6108 ◽  
Author(s):  
Jia Zhuang ◽  
Hua Gong ◽  
Jiarong Zhou ◽  
Qiangzhe Zhang ◽  
Weiwei Gao ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Gene Silencing ◽  
Targeted Delivery ◽  
Metal Organic Framework ◽  
Xenograft Model ◽  
Coated Metal ◽  
Wide Range ◽  
Metal Organic ◽  
Organic Framework

Small interfering RNA (siRNA) is a powerful tool for gene silencing that has been used for a wide range of biomedical applications, but there are many challenges facing its therapeutic use in vivo. Here, we report on a platelet cell membrane–coated metal-organic framework (MOF) nanodelivery platform for the targeted delivery of siRNA in vivo. The MOF core is capable of high loading yields, and its pH sensitivity enables endosomal disruption upon cellular uptake. The cell membrane coating provides a natural means of biointerfacing with disease substrates. It is shown that high silencing efficiency can be achieved in vitro against multiple target genes. Using a murine xenograft model, significant antitumor targeting and therapeutic efficacy are observed. Overall, the biomimetic nanodelivery system presented here provides an effective means of achieving gene silencing in vivo and could be used to expand the applicability of siRNA across a range of disease-relevant applications.

scholarly journals Multimodal Enzyme Delivery and Therapy Enabled by Cell Membrane-Coated Metal–Organic Framework Nanoparticles

Nano Letters ◽  
2020 ◽  
Vol 20 (5) ◽  
pp. 4051-4058 ◽  
Author(s):  
Jia Zhuang ◽  
Yaou Duan ◽  
Qiangzhe Zhang ◽  
Weiwei Gao ◽  
Shulin Li ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Metal Organic Framework ◽  
Coated Metal ◽  
Metal Organic ◽  
Enzyme Delivery ◽  
Organic Framework

scholarly journals A Zirconium Metal-Organic Framework with SOC Topological Net for Catalytic Peptide Bond Hydrolysis

2021 ◽  
Author(s):  
Sujing Wang ◽  
Antoine Tissot ◽  
Guillaume Maurin ◽  
Tatjana Parac-Vogt ◽  
Christian Serre ◽  
...  
Keyword(s):  
Active Sites ◽  
Metal Organic Framework ◽  
Cost Effective ◽  
Peptide Bond ◽  
Catalytic Performance ◽  
Wide Range ◽  
Horse Heart Myoglobin ◽  
Metal Organic ◽  
Effective Synthesis ◽  
Organic Framework

<div>The discovery of nanozymes for selective cleavage of proteins would boost the emerging areas of modern proteomics, however, the development of efficient and reusable artificial catalysts for peptide bond hydrolysis is challenging. Here we report the detailed catalytic properties of a microporous zirconium carboxylate metal-organic framework, MIP-201, in promoting peptide bond hydrolysis in a simple dipeptide, as well as in horse-heart myoglobin (Mb) protein that consists of 153 amino acids. We demonstrate that MIP-201 features an excellent catalytic activity and selectivity, a good tolerance toward reaction conditions covering a wide range of different pH values, and importantly, an exceptional recycling ability associated with easy regeneration process. Taking into account the excellent catalytic performance of MIP-201 and its other advantages such as 6-connected Zr6 cluster active sites, the green, scalable and cost-effective synthesis, and an outstanding chemical and architectural stability, our finding suggests that MIP-201 may be a promising and practical alternative to the current commercially available catalysts for peptide bond hydrolysis.</div>

scholarly journals A Zirconium Metal-Organic Framework with SOC Topological Net for Catalytic Peptide Bond Hydrolysis

2021 ◽  
Author(s):  
Sujing Wang ◽  
Antoine Tissot ◽  
Guillaume Maurin ◽  
Tatjana Parac-Vogt ◽  
Christian Serre ◽  
...  
Keyword(s):  
Active Sites ◽  
Metal Organic Framework ◽  
Cost Effective ◽  
Peptide Bond ◽  
Catalytic Performance ◽  
Wide Range ◽  
Horse Heart Myoglobin ◽  
Metal Organic ◽  
Effective Synthesis ◽  
Organic Framework

<div>The discovery of nanozymes for selective cleavage of proteins would boost the emerging areas of modern proteomics, however, the development of efficient and reusable artificial catalysts for peptide bond hydrolysis is challenging. Here we report the detailed catalytic properties of a microporous zirconium carboxylate metal-organic framework, MIP-201, in promoting peptide bond hydrolysis in a simple dipeptide, as well as in horse-heart myoglobin (Mb) protein that consists of 153 amino acids. We demonstrate that MIP-201 features an excellent catalytic activity and selectivity, a good tolerance toward reaction conditions covering a wide range of different pH values, and importantly, an exceptional recycling ability associated with easy regeneration process. Taking into account the excellent catalytic performance of MIP-201 and its other advantages such as 6-connected Zr6 cluster active sites, the green, scalable and cost-effective synthesis, and an outstanding chemical and architectural stability, our finding suggests that MIP-201 may be a promising and practical alternative to the current commercially available catalysts for peptide bond hydrolysis.</div>

Metal-organic framework (MOF) composites for photodegradation of hazardous organic materials

2021 ◽  
Vol 02 ◽  
Author(s):  
Xinxin Liu ◽  
Jiaqing Ren ◽  
Jiaqi Fang ◽  
An Pan ◽  
Nianqiao Qin ◽  
...  
Keyword(s):  
Photocatalytic Degradation ◽  
Organic Pollutants ◽  
Metal Organic Framework ◽  
Stable Process ◽  
Layer Growth ◽  
Thermal Method ◽  
Layer By Layer ◽  
Wide Range ◽  
Metal Organic ◽  
Organic Framework

: Photocatalytic degradation is an energy-efficient, cost-effective, and stable process that has a wide-range of applications. It is considered a promising method for the removal of organic pollutants. As a new type of porous materials, Metal-organic framework (MOF) composites have been proven to be an ideal catalyst for the degradation of organic pollutants due to their small size and large specific surface area. In this review, several common preparation methods of MOF composites are evaluated：microwave synthesis, solvent-thermal method, electrochemical method and layer by layer growth method. The degradation effects of MOF composites on different organic pollutants are summarized, and the excellent photocatalytic performances of some MOF composites are demonstrated. Finally, the prospect of photocatalytic degradation of organic pollutants by MOF composites is examined, and the challenges of further development of MOF composites are discussed.

Immobilization ofl-methioninase on a zirconium-based metal–organic framework as an anticancer agent

2019 ◽  
Vol 7 (20) ◽  
pp. 3268-3278 ◽  
Author(s):  
Amany A. Hassabo ◽  
Amria M. Mousa ◽  
Hassan Abdel-Gawad ◽  
Mohsen H. Selim ◽  
Reda M. Abdelhameed
Keyword(s):  
Tumor Growth ◽  
Anticancer Agent ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
And Storage ◽  
Organic Framework

A new composite (METase@UiO-66) was prepared froml-methioninase and UiO-66-(COOH), which exhibited enhanced thermostability, pH and storage lifetime compared tol-methioninase. Moreover,in vivoexperiments showed that the drug inhibited tumor growth in mice.

In Vivo Uranium Sequestration using a Nanoscale Metal–Organic Framework

2020 ◽  
Author(s):  
Xiaomei Wang ◽  
Lei Chen ◽  
Zhuanling Bai ◽  
Duo Zhang ◽  
Jingwen Guan ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Metal Organic ◽  
Uranium Sequestration ◽  
Organic Framework

Ru-Coated metal–organic framework-derived Co-based particles embedded in porous N-doped carbon nanocubes as a catalytic cathode for a Li–O2 battery

2019 ◽  
Vol 55 (68) ◽  
pp. 10092-10095 ◽  
Author(s):  
Dongdong Li ◽  
Haocheng Qi ◽  
Huiming Zhao ◽  
Ling Ding ◽  
Zhaoxiang Zhang ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
High Capacity ◽  
Cycle Life ◽  
Long Cycle ◽  
Long Cycle Life ◽  
Coated Metal ◽  
Metal Organic ◽  
Low Overpotential ◽  
Organic Framework

Ru-Co4N/Co-NC is prepared and used as a cathode for a Li–O2 battery, which shows high-capacity, low overpotential and long cycle-life.

scholarly journals Design of a Functionalized Metal–Organic Framework System for Enhanced Targeted Delivery to Mitochondria

2020 ◽  
Vol 142 (14) ◽  
pp. 6661-6674 ◽  
Author(s):  
Salame Haddad ◽  
Isabel Abánades Lázaro ◽  
Marcus Fantham ◽  
Ajay Mishra ◽  
Joaquin Silvestre-Albero ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Framework System ◽  
Organic Framework
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