scholarly journals Erythrocyte leveraged chemotherapy (ELeCt): Nanoparticle assembly on erythrocyte surface to combat lung metastasis

2019 ◽  
Vol 5 (11) ◽  
pp. eaax9250 ◽  
Author(s):  
Zongmin Zhao ◽  
Anvay Ukidve ◽  
Yongsheng Gao ◽  
Jayoung Kim ◽  
Samir Mitragotri
Keyword(s):  
Lung Metastasis ◽  
Late Stage ◽  
Chemotherapeutic Drugs ◽  
Drug Nanoparticles ◽  
Limited Efficacy ◽  
Erythrocyte Surface ◽  
Substantial Inhibition ◽  
Metastasis Models ◽  
Inhibition Of Tumor Growth ◽  
Tumor Accumulation

Despite being the mainstay of cancer treatment, chemotherapy has shown limited efficacy for the treatment of lung metastasis due to ineffective targeting and poor tumor accumulation. Here, we report a highly effective erythrocyte leveraged chemotherapy (ELeCt) platform, consisting of biodegradable drug nanoparticles assembled onto the surface of erythrocytes, to enable chemotherapy for lung metastasis treatment. The ELeCt platform significantly extended the circulation time of the drug nanoparticles and delivered 10-fold higher drug content to the lung compared with the free nanoparticles. In both the early- and late-stage melanoma lung metastasis models, the ELeCt platform enabled substantial inhibition of tumor growth that resulted in significant improvement of survival. Further, the ELeCt platform can be used to deliver numerous approved chemotherapeutic drugs. Together, the findings suggest that the ELeCt platform offers a versatile strategy to enable chemotherapy for effective lung metastasis treatment.

Gadolinium Oxide Nanoparticles Enhance the Cytotoxicity of Chemotherapeutic Drugs by Blocking Autophagic Flux in Human Ovarian Cancer Cells

2020 ◽  
Vol 16 ◽  
Author(s):  
Zhixiong Xie ◽  
Tianyu Zhang ◽  
Cheng Zhong
Keyword(s):  
Ovarian Cancer ◽  
Cancer Cells ◽  
Hela Cells ◽  
Late Stage ◽  
Ovarian Cancer Cells ◽  
Oxide Nanoparticles ◽  
Autophagic Flux ◽  
Human Ovarian Cancer ◽  
Chemotherapeutic Drugs ◽  
Chemotherapy Drugs

Background: During chemotherapy, drugs can damage cancer cells’ DNA and cytomembrane structure, and then induce cell death. However, autophagy can increase the chemotherapy resistance of cancer cells, reducing the effect of chemotherapy. Objective: To block the autophagic flux in cancer cells, it is vital to enhance the anti-cancer efficacy of chemotherapy drugs; for this purpose, we test the gadolinium oxide nanoparticles (Gd2O3 NPs)’ effect on autophagy. Methods: The cytotoxicity of Gd2O3 NPs on HeLa cells was evaluated by a (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Then, monodasylcadaverine staining, immunofluorescence, immunoblot and apoptosis assay were conducted to evaluate the effect of Gd2O3 NPs on autophagy and efficacy of chemotherapy drugs in human ovarian cancer cells. Results: We found that Gd2O3 NPs, which have great potential for use as a contrast agent in magnetic resonance imaging, could block the late stage of autophagic flux in a dose-dependent manner and then cause autophagosome accumulation in HeLa cells. When co-treated with 8 μg/mL Gd2O3 NPs and 5 μg/mL cisplatin, the number of dead HeLa cells increased by about 20% compared with cisplatin alone. We observed the same phenomenon in cisplatin-resistant COC1/DDP cells. Conclusion: We conclude that Gd2O3 NPs can block the late stage of autophagic flux and enhance the cytotoxicity of chemotherapeutic drugs in human ovarian cancer cells. Thus, the nanoparticles have significant potential for use in both diagnosis and therapy of solid tumor.

scholarly journals Synergistic effect of tumor chemo-immunotherapy induced by leukocyte-hitchhiking thermal-sensitive micelles

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Jing Qi ◽  
Feiyang Jin ◽  
Yuchan You ◽  
Yan Du ◽  
Di Liu ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Antitumor Immunity ◽  
Chemotherapeutic Drugs ◽  
Chemotherapeutic Drug ◽  
A2a Adenosine Receptor ◽  
Adenosine Receptor Antagonist ◽  
Tumor Immunosuppression ◽  
Tumor Immunogenicity ◽  
Sch 58261 ◽  
Tumor Accumulation

AbstractSome specific chemotherapeutic drugs are able to enhance tumor immunogenicity and facilitate antitumor immunity by inducing immunogenic cell death (ICD). However, tumor immunosuppression induced by the adenosine pathway hampers this effect. In this study, E-selectin-modified thermal-sensitive micelles are designed to co-deliver a chemotherapeutic drug (doxorubicin, DOX) and an A2A adenosine receptor antagonist (SCH 58261), which simultaneously exhibit chemo-immunotherapeutic effects when applied with microwave irradiation. After intravenous injection, the fabricated micelles effectively adhere to the surface of leukocytes in peripheral blood mediated by E-selectin, and thereby hitchhiking with leukocytes to achieve a higher accumulation at the tumor site. Further, local microwave irradiation is applied to induce hyperthermia and accelerates the release rate of drugs from micelles. Rapidly released DOX induces tumor ICD and elicits tumor-specific immunity, while SCH 58261 alleviates immunosuppression caused by the adenosine pathway, further enhancing DOX-induced antitumor immunity. In conclusion, this study presents a strategy to increase the tumor accumulation of drugs by hitchhiking with leukocytes, and the synergistic strategy of chemo-immunotherapy not only effectively arrested primary tumor growth, but also exhibited superior effects in terms of antimetastasis, antirecurrence and antirechallenge.

scholarly journals Colorectal cancer lung metastasis treatment with polymer–drug nanoparticles

2018 ◽  
Vol 275 ◽  
pp. 85-91 ◽  
Author(s):  
Piotr Rychahou ◽  
Younsoo Bae ◽  
Derek Reichel ◽  
Yekaterina Y. Zaytseva ◽  
Eun Y. Lee ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lung Metastasis ◽  
Drug Nanoparticles

scholarly journals Vessel co-option is common in human lung metastases and mediates resistance to anti-angiogenic therapy in preclinical lung metastasis models

2016 ◽  
Vol 241 (3) ◽  
pp. 362-374 ◽  
Author(s):  
Victoria L Bridgeman ◽  
Peter B Vermeulen ◽  
Shane Foo ◽  
Agnes Bilecz ◽  
Frances Daley ◽  
...  
Keyword(s):  
Lung Metastasis ◽  
Human Lung ◽  
Lung Metastases ◽  
Angiogenic Therapy ◽  
Metastasis Models

Abstract B38: Identification of highly metastatic disseminating tumor cells in late-stage liver cancer lung metastasis

2016 ◽  
Author(s):  
Liyuan Li ◽  
Melissa Johnson ◽  
Christopher Calabrese ◽  
David Finkelstein ◽  
Armita Bahrami ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Tumor Cells ◽  
Lung Metastasis ◽  
Late Stage

scholarly journals Reduced in vivo lung metastasis of a breast cancer cell line after treatment with Herceptin mAb conjugated to chemotherapeutic drugs

Oncogene ◽  
2012 ◽  
Vol 32 (20) ◽  
pp. 2527-2533 ◽  
Author(s):  
A Galan Garcia ◽  
H Nedev ◽  
K Bijian ◽  
J Su ◽  
M A Alaoui-Jamali ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Lung Metastasis ◽  
Breast Cancer Cell Line ◽  
Cancer Cell Line ◽  
Chemotherapeutic Drugs

scholarly journals S108 MIF as the key regulator for mesenchymal stem cells homing to tumours by 3D and in vivo lung metastasis models

Thorax ◽  
2014 ◽  
Vol 69 (Suppl 2) ◽  
pp. A58-A58
Author(s):  
S. Lourenco ◽  
V. Teixeira ◽  
T. Kalber ◽  
R. Thakrar ◽  
A. Floto ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Lung Metastasis ◽  
Metastasis Models

Multi-targeted inhibition of tumor growth and lung metastasis by redox-sensitive shell crosslinked micelles loading disulfiram

2014 ◽  
Vol 25 (12) ◽  
pp. 125102 ◽  
Author(s):  
Xiaopin Duan ◽  
Jisheng Xiao ◽  
Qi Yin ◽  
Zhiwen Zhang ◽  
Haijun Yu ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Lung Metastasis ◽  
Inhibition Of Tumor Growth ◽  
Targeted Inhibition ◽  
Crosslinked Micelles
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