scholarly journals VRK-1 extends life span by activation of AMPK via phosphorylation

2020 ◽  
Vol 6 (27) ◽  
pp. eaaw7824
Author(s):  
Sangsoon Park ◽  
Murat Artan ◽  
Seung Hyun Han ◽  
Hae-Eun H. Park ◽  
Yoonji Jung ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Life Span ◽  
Adult Life ◽  
Adult Life Span ◽  
C Elegans ◽  
Energy Sensor ◽  
Evolutionarily Conserved ◽  
Cultured Human Cells ◽  
Germline Proliferation ◽  
Amp Activated Protein Kinase

Vaccinia virus–related kinase (VRK) is an evolutionarily conserved nuclear protein kinase. VRK-1, the single Caenorhabditis elegans VRK ortholog, functions in cell division and germline proliferation. However, the role of VRK-1 in postmitotic cells and adult life span remains unknown. Here, we show that VRK-1 increases organismal longevity by activating the cellular energy sensor, AMP-activated protein kinase (AMPK), via direct phosphorylation. We found that overexpression of vrk-1 in the soma of adult C. elegans increased life span and, conversely, inhibition of vrk-1 decreased life span. In addition, vrk-1 was required for longevity conferred by mutations that inhibit C. elegans mitochondrial respiration, which requires AMPK. VRK-1 directly phosphorylated and up-regulated AMPK in both C. elegans and cultured human cells. Thus, our data show that the somatic nuclear kinase, VRK-1, promotes longevity through AMPK activation, and this function appears to be conserved between C. elegans and humans.

scholarly journals TSG (2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside) from the Chinese HerbPolygonum multiflorumIncreases Life Span and Stress Resistance ofCaenorhabditis elegans

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Christian Büchter ◽  
Liang Zhao ◽  
Susannah Havermann ◽  
Sebastian Honnen ◽  
Gerhard Fritz ◽  
...  
Keyword(s):  
Life Span ◽  
Stress Resistance ◽  
Adult Life ◽  
Model Organism ◽  
Antioxidative Capacity ◽  
Loss Of Function ◽  
Polygonum Multiflorum ◽  
Adult Life Span ◽  
C Elegans ◽  
Related Transcription Factor

2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG) was isolated fromPolygonum multiflorum, a plant which is traditionally used as an anti-ageing drug. We have analysed ageing-related effects of TSG in the model organismC. elegansin comparison to resveratrol. TSG exerted a high antioxidative capacity both in a cell-free assay and in the nematode. The antioxidative capacity was even higher compared to resveratrol. Presumably due to its antioxidative effects, treatment with TSG decreased the juglone-mediated induction of the antioxidative enzyme SOD-3; the induction of the GST-4 by juglone was diminished slightly. TSG increased the resistance ofC. elegansagainst lethal thermal stress more prominently than resveratrol (50 μM TSG increased mean survival by 22.2%). The level of the ageing pigment lipofuscin was decreased after incubation with the compound. TSG prolongs the mean, median, and maximum adult life span ofC. elegansby 23.5%, 29.4%, and 7.2%, respectively, comparable to the effects of resveratrol. TSG-mediated extension of life span was not abolished in a DAF-16 loss-of-function mutant strain showing that this ageing-related transcription factor is not involved in the effects of TSG. Our data show that TSG possesses a potent antioxidative capacity, enhances the stress resistance, and increases the life span of the nematodeC. elegans.

scholarly journals Calorie Restriction: Is AMPK a Key Sensor and Effector?

Physiology ◽  
2011 ◽  
Vol 26 (4) ◽  
pp. 214-224 ◽  
Author(s):  
Carles Cantó ◽  
Johan Auwerx
Keyword(s):  
Protein Kinase ◽  
Life Span ◽  
Calorie Restriction ◽  
Energy Availability ◽  
Beneficial Effects ◽  
Extend Life Span ◽  
Energy Sensor ◽  
External Cues ◽  
Amp Activated Protein Kinase

Dietary restriction can extend life span in most organisms tested to date, suggesting that mechanisms sensing nutrient and energy availability might regulate longevity. The AMP-activated protein kinase (AMPK) has emerged as a key energy sensor with the ability to transcriptionally reprogram the cell and metabolically adapt to external cues. In this review, we will discuss the possible role of AMPK in the beneficial effects of calorie restriction on health and life span.

scholarly journals A Genetic Pathway Conferring Life Extension and Resistance to UV Stress in Caenorhabditis elegans

Genetics ◽  
1996 ◽  
Vol 143 (3) ◽  
pp. 1207-1218 ◽  
Author(s):  
Shin Murakami ◽  
Thomas E Johnson
Keyword(s):  
Caenorhabditis Elegans ◽  
Life Span ◽  
Stress Resistance ◽  
Biological Clock ◽  
Adult Life ◽  
Life Extension ◽  
Uv Resistance ◽  
Wild Type ◽  
Adult Life Span ◽  
C Elegans

Abstract A variety of mechanisms have been proposed to explain the extension of adult life span (Age) seen in several mutants in Caenorhabditis elegans (age-1: an altered aging rate; daf-2 and daf-23 activation of a dauer-specific longevity program; spe-26: reduced fertility; ck-1: an altered biological clock). Using an assay for ultraviolet (UV) resistance in young adult hermaphrodites (survival after UV irradiation), we observed that all these Age mutants show increased resistance to UV. Moreover, mutations in daf-16 suppressed the UV resistance as well as the increased longevity of all the Age mutants. In contrast to the multiple mechanisms initially proposed, these results suggest that a single, daf-16dependent pathway, specifies both extended life span and increased UV resistance. The mutations in daf-16 did not alter the reduced fertility of spe-26and interestingly a daf-16mutant is more fertile than wild type. We propose that life span and some aspects of stress resistance are jointly negatively regulated by a set of gerontogenes (genes whose alteration causes life extension) in C. elegans.

Interdisciplinary Adult Life Span Learning (Really!)

1996 ◽  
Vol 41 (6) ◽  
pp. 590-591
Author(s):  
Barbara R. Bjorklund
Keyword(s):  
Life Span ◽  
Adult Life ◽  
Adult Life Span

Emotion experience and expression across the adult life span: Insights from a multimodal assessment study.

2006 ◽  
Vol 21 (2) ◽  
pp. 303-317 ◽  
Author(s):  
Carol Magai ◽  
Nathan S. Consedine ◽  
Yulia S. Krivoshekova ◽  
Elizabeth Kudadjie-Gyamfi ◽  
Renee McPherson
Keyword(s):  
Life Span ◽  
Adult Life ◽  
Adult Life Span ◽  
Multimodal Assessment ◽  
Emotion Experience ◽  
Assessment Study

Interchannel Relationships for Emotional Perception Across the Adult Life Span

2008 ◽  
Author(s):  
Katie Finley ◽  
Joan C. Borod ◽  
Adam Brickman ◽  
J. M. Schmidt ◽  
Stephanie Assuras ◽  
...  
Keyword(s):  
Life Span ◽  
Adult Life ◽  
Adult Life Span ◽  
Emotional Perception

Modeling Spoken Discourse Comprehension Across the Adult Life Span

2008 ◽  
Author(s):  
Sandra Hale ◽  
Mitchell S. Sommers ◽  
Joel Myerson ◽  
Nancy Tye-Murray ◽  
Nathan Rose ◽  
...  
Keyword(s):  
Life Span ◽  
Adult Life ◽  
Discourse Comprehension ◽  
Adult Life Span ◽  
Spoken Discourse

Decoy effects in preferential choice across the adult life span

2006 ◽  
Author(s):  
Mark E. Faust ◽  
Kristi S. Multhaup ◽  
Patricia A. Brooks ◽  
Sarah Frey ◽  
Blair Hicks ◽  
...  
Keyword(s):  
Life Span ◽  
Adult Life ◽  
Adult Life Span ◽  
Preferential Choice ◽  
Decoy Effects
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