scholarly journals A central control circuit for encoding perceived food value

2018 ◽  
Vol 4 (11) ◽  
pp. eaau9180 ◽  
Author(s):  
Michael Crossley ◽  
Kevin Staras ◽  
György Kemenes
Keyword(s):  
Neural Circuit ◽  
Pattern Generator ◽  
Central Control ◽  
Network Reconfiguration ◽  
Motor Patterns ◽  
Independent Manner ◽  
Sensory Modalities ◽  
Sensory Cue ◽  
Food Value ◽  
Hungry Animal

Hunger state can substantially alter the perceived value of a stimulus, even to the extent that the same sensory cue can trigger antagonistic behaviors. How the nervous system uses these graded perceptual shifts to select between opposed motor patterns remains enigmatic. Here, we challenged food-deprived and satiated Lymnaea to choose between two mutually exclusive behaviors, ingestion or egestion, produced by the same feeding central pattern generator. Decoding the underlying neural circuit reveals that the activity of central dopaminergic interneurons defines hunger state and drives network reconfiguration, biasing satiated animals toward the rejection of stimuli deemed palatable by food-deprived ones. By blocking the action of these neurons, satiated animals can be reconfigured to exhibit a hungry animal phenotype. This centralized mechanism occurs in the complete absence of sensory retuning and generalizes across different sensory modalities, allowing food-deprived animals to increase their perception of food value in a stimulus-independent manner to maximize potential calorific intake.

scholarly journals A central control circuit for encoding perceived food value

2018 ◽  
Author(s):  
Michael Crossley ◽  
Kevin Staras ◽  
György Kemenes
Keyword(s):  
Neural Circuit ◽  
Pattern Generator ◽  
Central Control ◽  
Network Reconfiguration ◽  
Motor Patterns ◽  
Independent Manner ◽  
Sensory Modalities ◽  
Sensory Cue ◽  
Food Value ◽  
Hungry Animal

Hunger state can substantially alter the perceived value of a stimulus, even to the extent that the same sensory cue can trigger antagonistic behaviors. How the nervous system uses such graded perceptual shifts to select between opposed motor patterns remains enigmatic. Here we challenged food-deprived and satiated Lymnaea to choose between two mutually exclusive behaviors, ingestion or egestion, produced by the same feeding central pattern generator. Decoding the underlying neural circuit reveals that the activity of central dopaminergic interneurons defines hunger state and drives network reconfiguration, biasing satiated animals towards the rejection of stimuli deemed palatable by food-deprived ones. By blocking the action of these neurons, satiated animals can be reconfigured to exhibit a hungry animal phenotype. This centralized mechanism occurs in the complete absence of sensory retuning and generalizes across different sensory modalities, allowing food-deprived animals to increase their perception of food value in a stimulus-independent manner to maximize potential calorific intake.

Swallow Pattern Generator Reconfiguration of the Respiratory Neural Network

2009 ◽  
Vol 18 (1) ◽  
pp. 3-12
Author(s):  
Andrea Vovka ◽  
Paul W. Davenport ◽  
Karen Wheeler-Hegland ◽  
Kendall F. Morris ◽  
Christine M. Sapienza ◽  
...  
Keyword(s):  
Behavioral Control ◽  
Upper Airway ◽  
Pattern Generator ◽  
Breathing Patterns ◽  
Motor Patterns ◽  
Control Assembly ◽  
Pharyngeal Swallow ◽  
Laryngeal Vestibule ◽  
Lower Airways ◽  
Swallow Apnea

Abstract When the nasal and oral passages converge and a bolus enters the pharynx, it is critical that breathing and swallow motor patterns become integrated to allow safe passage of the bolus through the pharynx. Breathing patterns must be reconfigured to inhibit inspiration, and upper airway muscle activity must be recruited and reconfigured to close the glottis and laryngeal vestibule, invert the epiglottis, and ultimately protect the lower airways. Failure to close and protect the glottal opening to the lower airways, or loss of the integration and coordination of swallow and breathing, increases the risk of penetration or aspiration. A neural swallow central pattern generator (CPG) controls the pharyngeal swallow phase and is located in the medulla. We propose that this swallow CPG is functionally organized in a holarchical behavioral control assembly (BCA) and is recruited with pharyngeal swallow. The swallow BCA holon reconfigures the respiratory CPG to produce the stereotypical swallow breathing pattern, consisting of swallow apnea during swallowing followed by prolongation of expiration following swallow. The timing of swallow apnea and the duration of expiration is a function of the presence of the bolus in the pharynx, size of the bolus, bolus consistency, breath cycle, ventilatory state and disease.

scholarly journals The role of carbon dioxide in nematode behaviour and physiology

Parasitology ◽  
2019 ◽  
Vol 147 (8) ◽  
pp. 841-854 ◽  
Author(s):  
Navonil Banerjee ◽  
Elissa A. Hallem
Keyword(s):  
Carbon Dioxide ◽  
Neural Circuit ◽  
Physiological Responses ◽  
Life Stage ◽  
Free Living ◽  
Behavioural Responses ◽  
Wide Range ◽  
Sensory Cue ◽  
Context Dependent

AbstractCarbon dioxide (CO2) is an important sensory cue for many animals, including both parasitic and free-living nematodes. Many nematodes show context-dependent, experience-dependent and/or life-stage-dependent behavioural responses to CO2, suggesting that CO2 plays crucial roles throughout the nematode life cycle in multiple ethological contexts. Nematodes also show a wide range of physiological responses to CO2. Here, we review the diverse responses of parasitic and free-living nematodes to CO2. We also discuss the molecular, cellular and neural circuit mechanisms that mediate CO2 detection in nematodes, and that drive context-dependent and experience-dependent responses of nematodes to CO2.

Fast Synaptic Connections From CBIs to Pattern-Generating Neurons in Aplysia: Initiation and Modification of Motor Programs

2003 ◽  
Vol 89 (4) ◽  
pp. 2120-2136 ◽  
Author(s):  
Itay Hurwitz ◽  
Irving Kupfermann ◽  
Klaudiusz R. Weiss
Keyword(s):  
Central Pattern Generator ◽  
Motor Pattern ◽  
Aplysia Californica ◽  
Pattern Generator ◽  
Synaptic Connections ◽  
Motor Patterns ◽  
Motor Programs ◽  
Postsynaptic Potentials ◽  
Buccal Ganglia ◽  
Very High

Consummatory feeding movements in Aplysia californica are organized by a central pattern generator (CPG) in the buccal ganglia. Buccal motor programs similar to those organized by the CPG are also initiated and controlled by the cerebro-buccal interneurons (CBIs), interneurons projecting from the cerebral to the buccal ganglia. To examine the mechanisms by which CBIs affect buccal motor programs, we have explored systematically the synaptic connections from three of the CBIs (CBI-1, CBI-2, CBI-3) to key buccal ganglia CPG neurons (B31/B32, B34, and B63). The CBIs were found to produce monosynaptic excitatory postsynaptic potentials (EPSPs) with both fast and slow components. In this report, we have characterized only the fast component. CBI-2 monosynaptically excites neurons B31/B32, B34, and B63, all of which can initiate motor programs when they are sufficiently stimulated. However, the ability of CBI-2 to initiate a program stems primarily from the excitation of B63. In B31/B32, the size of the EPSPs was relatively small and the threshold for excitation was very high. In addition, preventing firing in either B34 or B63 showed that only a block in B63 firing prevented CBI-2 from initiating programs in response to a brief stimulus. The connections from CBI-2 to the buccal ganglia neurons showed a prominent facilitation. The facilitation contributed to the ability of CBI-2 to initiate a BMP and also led to a change in the form of the BMP. The cholinergic blocker hexamethonium blocked the fast EPSPs induced by CBI-2 in buccal ganglia neurons and also blocked the EPSPs between a number of key CPG neurons within the buccal ganglia. CBI-2 and B63 were able to initiate motor patterns in hexamethonium, although the form of a motor pattern was changed, indicating that non-hexamethonium-sensitive receptors contribute to the ability of these cells to initiate bursts. By contrast to CBI-2, CBI-1 excited B63 but inhibited B34. CBI-3 excited B34 and not B63. The data indicate that CBI-1, -2, and -3 are components of a system that initiates and selects between buccal motor programs. Their behavioral function is likely to depend on which combination of CBIs and CPG elements are activated.

Simultaneous and Independent Acquisition of Multisensory and Unisensory Associations

Perception ◽  
10.1068/p5843 ◽  
2007 ◽  
Vol 36 (10) ◽  
pp. 1445-1453 ◽  
Author(s):  
Aaron R Seitz ◽  
Robyn Kim ◽  
Virginie van Wassenhove ◽  
Ladan Shams
Keyword(s):  
Statistical Learning ◽  
Visual Stimulus ◽  
Daily Life ◽  
Visual Stimuli ◽  
Forced Choice ◽  
Independent Manner ◽  
Choice Procedure ◽  
Learning Procedure ◽  
Sensory Modalities ◽  
Forced Choice Procedure

Although humans are almost constantly exposed to stimuli from multiple sensory modalities during daily life, the processes by which we learn to integrate information from multiple senses to acquire knowledge of multisensory objects are not well understood. Here, we present results of a novel audio – visual statistical learning procedure where participants are passively exposed to a rapid serial presentation of arbitrary audio — visual pairings (comprised of artificial/synthetic audio and visual stimuli). Following this exposure, participants were tested with a two-interval forced-choice procedure in which their degree of familiarity with the experienced audio-visual pairings was evaluated against novel audio — visual combinations drawn from the same stimulus set. Our results show that subjects acquire knowledge of visual — visual, audio — audio, and audio — visual stimulus associations and that the learning of these types of associations occurs in an independent manner.

scholarly journals Hearing regulatesDrosophilaaggression

2017 ◽  
Vol 114 (8) ◽  
pp. 1958-1963 ◽  
Author(s):  
Marijke Versteven ◽  
Lies Vanden Broeck ◽  
Bart Geurten ◽  
Liesbeth Zwarts ◽  
Lisse Decraecker ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Social Behavior ◽  
Aggressive Behavior ◽  
Social Status ◽  
Neural Circuit ◽  
Sensory Modality ◽  
Intermale Aggression ◽  
Mechanical Disruption ◽  
Sensory Modalities ◽  
Auditory Organ

Aggression is a universal social behavior important for the acquisition of food, mates, territory, and social status. Aggression inDrosophilais context-dependent and can thus be expected to involve inputs from multiple sensory modalities. Here, we use mechanical disruption and genetic approaches inDrosophila melanogasterto identify hearing as an important sensory modality in the context of intermale aggressive behavior. We demonstrate that neuronal silencing and targeted knockdown of hearing genes in the fly’s auditory organ elicit abnormal aggression. Further, we show that exposure to courtship or aggression song has opposite effects on aggression. Our data define the importance of hearing in the control ofDrosophilaintermale aggression and open perspectives to decipher how hearing and other sensory modalities are integrated at the neural circuit level.

Feeding State-Dependent Modulation of Feeding-Related Motor Patterns

2021 ◽  
Author(s):  
Aaron P. Cook ◽  
Michael P. Nusbaum
Keyword(s):  
Neural Circuit ◽  
Projection Neuron ◽  
Neuron Activity ◽  
Gastric Mill ◽  
Stomatogastric Nervous System ◽  
Cancer Borealis ◽  
Motor Patterns ◽  
State Dependent ◽  
Reduced Activity ◽  
Time Point

Studies elucidating modulation of microcircuit activity in isolated nervous systems have revealed numerous insights regarding neural circuit flexibility, but this approach limits the link between experimental results and behavioral context. To bridge this gap, we studied feeding behavior-linked modulation of microcircuit activity in the isolated stomatogastric nervous system (STNS) of male Cancer borealis crabs. Specifically, we removed hemolymph from a crab that was unfed for ≥24 h ('unfed' hemolymph) or fed 15 min - 2 h before hemolymph removal ('fed' hemolymph). After feeding, the first significant foregut emptying occurred >1 h later and complete emptying required ≥6 h. We applied the unfed or fed hemolymph to the stomatogastric ganglion (STG) in an isolated STNS preparation from a separate, unfed crab to determine its influence on the VCN (ventral cardiac neuron)-triggered gastric mill (chewing)- and pyloric (filtering of chewed food) rhythms. Unfed hemolymph had little influence on these rhythms, but fed hemolymph from each examined time-point (15 min, 1- or 2 h post-feeding) slowed one or both rhythms without weakening circuit neuron activity. There were also distinct parameter changes associated with each time-point. One change unique to the 1 h time-point (i.e. reduced activity of one circuit neuron during the transition from the gastric mill retraction to protraction phase) suggested the fed hemolymph also enhanced the influence of a projection neuron which innervates the STG from a ganglion isolated from the applied hemolymph. Hemolymph thus provides a feeding state-dependent modulation of the two feeding-related motor patterns in the C. borealis STG.

Movements and Motor Patterns of the Buccal Mass of Pleurobranchaea During Feeding, Regurgitation and Rejection

1982 ◽  
Vol 98 (1) ◽  
pp. 195-211
Author(s):  
ANDREW D. McCLELLAN
Keyword(s):  
Motor Activity ◽  
Motor Pattern ◽  
Pattern Generator ◽  
Behavioural Response ◽  
Rhythmic Movements ◽  
Motor Patterns ◽  
Jaw Muscles ◽  
Behavioural Responses ◽  
Buccal Mass ◽  
Different Types

Feeding, regurgitation, and rejection in the marine gastropod Pleurobranchaea all involve similar but not identical rhythmic movements of buccal mass structures such as the radula, jaws and lips. The part of the motor pattern which produces rhythmic radula movement, as recorded in the major external muscles of the buccal mass of behaving semi-intact preparations, was similar during the three different types of behaviour, suggesting that they share a common motor-pattern generator. Other parts of the motor pattern were only obviously different during the vomiting phase of regurgitation. Differences in the function and motor patterns of feeding and rejection are presumably accounted for by differences in the activity of muscles which could not be recorded from in this study (e.g. jaw muscles). A general conclusion is that buccal rhythms in gastropods cannot automatically be assumed to underlie feeding, and this is particularly true for dissected preparations which do not execute a clear behavioural response. It would be necessary either to record motor activity that is unique for a given behaviour, or to employ preparations which execute unambiguous behavioural responses.

Evolution of air-breathing and central CO(2)/H(+) respiratory chemosensitivity: new insights from an old fish?

2000 ◽  
Vol 203 (22) ◽  
pp. 3505-3512 ◽  
Author(s):  
R.J. Wilson ◽  
M.B. Harris ◽  
J.E. Remmers ◽  
S.F. Perry
Keyword(s):  
Central Pattern Generator ◽  
Motor Pattern ◽  
Lung Ventilation ◽  
Pattern Generator ◽  
Motor Patterns ◽  
Air Breathing ◽  
Longnose Gar ◽  
Isolated Brainstem

While little is known of the origin of air-breathing in vertebrates, primitive air breathers can be found among extant lobe-finned (Sarcopterygii) and ray-finned (Actinopterygii) fish. The descendents of Sarcopterygii, the tetrapods, generate lung ventilation using a central pattern generator, the activity of which is modulated by central and peripheral CO(2)/H(+) chemoreception. Air-breathing in Actinopterygii, in contrast, has been considered a ‘reflexive’ behaviour with little evidence for central CO(2)/H(+) respiratory chemoreceptors. Here, we describe experiments using an in vitro brainstem preparation of a primitive air-breathing actinopterygian, the longnose gar Lepisosteus osseus. Our data suggest (i) that gill and air-breathing motor patterns can be produced autonomously by the isolated brainstem, and (ii) that the frequency of the air-breathing motor pattern is increased by hypercarbia. These results are the first evidence consistent with the presence of an air-breathing central pattern generator with central CO(2)/H(+) respiratory chemosensitivity in any primitive actinopterygian fish. We speculate that the origin of the central neuronal controller for air-breathing preceded the divergence of the sarcopterygian and actinopterygian lineages and dates back to a common air-breathing ancestor.

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