scholarly journals International Union of Basic and Clinical Pharmacology. XCIII. The Parathyroid Hormone Receptors—Family B G Protein–Coupled Receptors

2015 ◽  
Vol 67 (2) ◽  
pp. 310-337 ◽  
Author(s):  
Thomas J. Gardella ◽  
Jean-Pierre Vilardaga
Keyword(s):  
Clinical Pharmacology ◽  
Parathyroid Hormone ◽  
G Protein ◽  
Hormone Receptors ◽  
G Protein Coupled Receptors ◽  
International Union ◽  
G Protein Coupled

scholarly journals Parathyroid hormone receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

2019 ◽  
Vol 2019 (4) ◽  
Author(s):  
Alessandro Bisello ◽  
Michael Chorev ◽  
Peter A. Friedman ◽  
Tom Gardella ◽  
Rebecca Hills ◽  
...  
Keyword(s):  
Amino Acids ◽  
Parathyroid Hormone ◽  
G Protein ◽  
Hormone Receptors ◽  
G Protein Coupled Receptors ◽  
Related Peptide ◽  
Parathyroid Hormone Related Peptide ◽  
Pthrp Receptor ◽  
G Protein Coupled ◽  
Pth1 Receptor

The parathyroid hormone receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Parathyroid Hormone Receptors [47]) are family B G protein-coupled receptors. The parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor (PTH1 receptor) is activated by precursor-derived peptides: PTH (84 amino acids), and PTHrP (141 amino-acids) and related peptides (PTH-(1-34), PTHrP-(1-36)). The parathyroid hormone 2 receptor (PTH2 receptor) is activated by the precursor-derived peptide TIP39 (39 amino acids). [125I]PTH may be used to label both PTH1 and PTH2 receptors.

scholarly journals International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors

2015 ◽  
Vol 67 (2) ◽  
pp. 338-367 ◽  
Author(s):  
Jörg Hamann ◽  
Gabriela Aust ◽  
Demet Araç ◽  
Felix B. Engel ◽  
Caroline Formstone ◽  
...  
Keyword(s):  
Clinical Pharmacology ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
International Union ◽  
G Protein Coupled

A cloning strategy for G-protein-coupled hormone receptors: the ovine beta 1-adrenergic receptor

1995 ◽  
Vol 7 (3) ◽  
pp. 521 ◽  
Author(s):  
JF Padbury ◽  
YT Tseng ◽  
JA Waschek
Keyword(s):  
G Protein ◽  
Sequence Homology ◽  
Hormone Receptors ◽  
Genomic Library ◽  
Receptor Gene ◽  
G Protein Coupled Receptors ◽  
Transcriptional Level ◽  
Fetal Life ◽  
Single Clone ◽  
G Protein Coupled

Regulation of beta 1-adrenergic receptors is unusual in developing animals. For example, glucocorticoid-and thyroid hormone-responsiveness for several genes is seen in animals treated during fetal life but beta 1-responsiveness is not seen until after birth. In order to investigate this at the transcriptional level, the ovine beta 1 receptor gene was cloned from a sheep genomic library. An approach using high-stringency screening with cDNA probes and oligonucleotides from regions of human and rat genes conserved but unique to the beta 1 receptor but not to other seven transmembrane, G-protein-coupled receptors. Over 800,000 clones were screened from which 40-50 positive clones were identified by each of the probes. There was, however, only a single clone which was recognized by each of the probes. A 5-kb insert was subcloned and shown to contain sequences which hybridized to each of the probes. Using the restriction map of the rat beta 1 receptor, a 1.0-kb Pst1 internal fragment was further subcloned for sequence identification. Confirmation of this fragment as the ovine beta 1 receptor was based on homology of the beta 1 receptor from other species and tissue distribution of mRNA. Nucleotide sequence homology was 93% with the human beta 1 receptor and 84% with rat. Amino acid sequence homology was > 75% and approached 100% in the transmembrane regions. The approach described represents a practical approach to cloning and identification of hormone receptors from the highly homologous members of the seven-transmembrane, G-protein-coupled receptors.

International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the Recognition and Nomenclature of G Protein-Coupled Receptor Heteromultimers

2007 ◽  
Vol 59 (1) ◽  
pp. 5-13 ◽  
Author(s):  
Jean-Philippe Pin ◽  
Richard Neubig ◽  
Michel Bouvier ◽  
Lakshmi Devi ◽  
Marta Filizola ◽  
...  
Keyword(s):  
Clinical Pharmacology ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
International Union ◽  
G Protein Coupled

Bioinformatics and type II G-protein-coupled receptors

2002 ◽  
Vol 30 (4) ◽  
pp. 473-479 ◽  
Author(s):  
S. M. Foord ◽  
S. Jupe ◽  
J. Holbrook
Keyword(s):  
Parathyroid Hormone ◽  
G Protein ◽  
Sequence Homology ◽  
G Protein Coupled Receptors ◽  
Type Ii ◽  
Corticotrophin Releasing Factor ◽  
Large N ◽  
G Protein Coupled ◽  
7Tm Receptors

The best known family B, or Type II, G-protein-coupled receptors (GPCRs) recognize peptides as ligands. The receptors for corticotrophin-releasing factor, parathyroid hormone and secretin typify this group. However, there are only 15 such GPCRs. Many other receptors share sequence homology and have been assigned to this family. The ten ‘Frizzled’ and one ‘Smoothened’ receptors show the lowest sequence homology and are not necessarily G-protein coupled. Drosophila genetics have enabled our understanding of their biology. In contrast, relatively little is known about the largest group with family B, the 33 ‘large amino termini’ or large N-terminal family B seven-transmembrane (LNB 7TM) receptors. This review highlights the similarities found between family B receptors and provides a classification of LNB 7TM receptors.

Corticotropin-releasing hormone receptors

2002 ◽  
Vol 30 (4) ◽  
pp. 428-432 ◽  
Author(s):  
E. W. Hillhouse ◽  
H. Randeva ◽  
G. Ladds ◽  
D. Grammatopoulos
Keyword(s):  
G Protein ◽  
Hormone Receptors ◽  
G Protein Coupled Receptors ◽  
Corticotropin Releasing Hormone ◽  
Functional Characteristics ◽  
Releasing Hormone ◽  
The Family ◽  
G Protein Coupled

Corticotropin-releasing hormone (CRH) and related peptides (urocortins, sauvagine, urotensin) play a central role in the co-ordination of autonomic, behavioural, cardiovascular, immune and endocrine responses to stressful stimuli. Their actions are mediated through activation of two types of G-protein-coupled receptors encoded by separate genes. In this review we focus on the diverse structural and functional characteristics of the family of CRH-like peptides and their receptors.

scholarly journals SNP analysis, genotyping and mapping of the porcine <i>PTHR1</i> gene to chromosome 13 (Brief report)

2007 ◽  
Vol 50 (3) ◽  
pp. 320-321 ◽  
Author(s):  
S. Tetzlaff ◽  
S. Ponsuksili ◽  
E. Murani ◽  
K. Schellander ◽  
K. Wimmers
Keyword(s):  
Mammary Gland ◽  
Parathyroid Hormone ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
Type I ◽  
Snp Analysis ◽  
Chromosome 13 ◽  
The Family ◽  
Porcine Gene ◽  
G Protein Coupled

Abstract. The parathyroid hormone/parathyroid hormone like hormone type I receptor (PTHR1) belongs to the family of G protein-coupled receptors for peptide hormones, including parathyroid hormone (PTH) and parathyroid hormone like hormone (PTHLH), which participate in epithelial-mesenchymal interactions during the formation and differentiation of epithelial organs (FOLEY et al., 2001; CHOMDEJ et al., 2004). The function of PTHR1 and its ligands suggest its candidacy for traits related to the development of bones and joints but also of mammary gland. The porcine gene was screened for SNPs and assigned to SSC13.

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