scholarly journals α6β2* and α4β2* Nicotinic Acetylcholine Receptors As Drug Targets for Parkinson's Disease

2011 ◽  
Vol 63 (4) ◽  
pp. 938-966 ◽  
Author(s):  
Maryka Quik ◽  
Susan Wonnacott
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Drug Targets ◽  
Nicotinic Acetylcholine

Nicotinic acetylcholine receptors in the patients with Parkinson's disease: 5IA-SPECT

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S586-S586 ◽  
Author(s):  
Kazuo Hashikawa ◽  
Hidefumi Yoshida ◽  
Nobukatsu Sawamoto ◽  
Shigetoshi Takaya ◽  
Chihiro Namiki ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Nicotinic Acetylcholine

Targeting the Nicotinic Acetylcholine Receptors (nAChRs) in Astrocytes as a Potential Therapeutic Target in Parkinson's Disease

2016 ◽  
Vol 22 (10) ◽  
pp. 1305-1311 ◽  
Author(s):  
Juan Camilo Jurado-Coronel ◽  
Marco Avila-Rodriguez ◽  
Francisco Capani ◽  
Janneth Gonzalez ◽  
Valentina Echeverria Moran ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Nicotinic Acetylcholine Receptors ◽  
Therapeutic Target ◽  
Acetylcholine Receptors ◽  
Potential Therapeutic Target ◽  
Nicotinic Acetylcholine

scholarly journals Quantification of nicotinic acetylcholine receptors in Parkinson's disease with 123I-5IA SPECT

2007 ◽  
Vol 256 (1-2) ◽  
pp. 52-60 ◽  
Author(s):  
Naoya Oishi ◽  
Kazuo Hashikawa ◽  
Hidefumi Yoshida ◽  
Koichi Ishizu ◽  
Masashi Ueda ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Nicotinic Acetylcholine

Alpha and beta nicotinic acetylcholine receptors subunits and synaptophysin in putamen from Parkinson's disease

2000 ◽  
Vol 39 (13) ◽  
pp. 2830-2839 ◽  
Author(s):  
C.M Martin-Ruiz ◽  
M Piggott ◽  
C Gotti ◽  
J Lindstrom ◽  
A.D Mendelow ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Nicotinic Acetylcholine

scholarly journals Possible involvement of neuronal nicotinic acetylcholine receptors in compensatory brain mechanisms at early stages of Parkinson's disease

2017 ◽  
Vol 63 (3) ◽  
pp. 241-247 ◽  
Author(s):  
E.V. Kryukova ◽  
I.V. Shelukhina ◽  
A.A. Kolacheva ◽  
A.Kh. Alieva ◽  
M.I. Shadrina ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Fold Increase ◽  
Receptor Subtype ◽  
Compensatory Mechanisms ◽  
Gene Encoding ◽  
Nicotinic Acetylcholine ◽  
Presymptomatic Stage

A role of nicotinic acetylcholine receptors (nAChR) in the development of Parkinson's disease (PD) has been investigated using two mouse models corresponding to the presymptomatic stage and the early symptomatic stage of PD. Quantitative determination of nAChR in the striatum and substantia nigra (SN) was performed using the radioactive derivatives of epibatidine, -conotoxin MII, and -bungarotoxin as ligands. The number of ligand-binding sites changed differently depending on their location in the brain, the stage of the disease and the receptor subtype. Epibatidine binding decreased in the striatum to 66% and 70% at the presymptomatic and early symptomatic stages, respectively, whereas in SN a 160% increase was registered at the presymptomatic stage. The -conotoxin MII binding on striatal dopaminergic axonal terminals at the presymptomatic stage decreased by 20% and at the symptomatic stage it demonstrated a further decrease. The increase in -bungarotoxin binding at the presymptomatic stage and a decrease at the early symptomatic stage was observed in the striatum. In SN, the level of -bungarotoxin binding decreased at the presymptomatic stage and kept constant at the symptomatic stage. The significant decrease in the expression of Chrna4 and Chrna6 genes encoding 4 and 6 nAChR subunits was observed in SN at the early symptomatic stage, while a 13-fold increase in expression of the Chrna7 gene encoding the 7 nAChR subunit was detected at the presymptomatic stage. The data obtained suggest possible involvement of nAChR in compensatory mechanisms at early PD stages.

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