Dexamethasone Promotes Toxicity in U937 Cells Exposed to Otherwise Nontoxic Concentrations of Peroxynitrite: Pivotal Role for Lipocortin 1-Mediated Inhibition of Cytosolic Phospholipase A2

Ilaria Tommasini; Orazio Cantoni

doi:10.1124/mol.65.4.964

Dexamethasone Promotes Toxicity in U937 Cells Exposed to Otherwise Nontoxic Concentrations of Peroxynitrite: Pivotal Role for Lipocortin 1-Mediated Inhibition of Cytosolic Phospholipase A2

Molecular Pharmacology ◽

10.1124/mol.65.4.964 ◽

2004 ◽

Vol 65 (4) ◽

pp. 964-972 ◽

Cited By ~ 11

Author(s):

Ilaria Tommasini ◽

Orazio Cantoni

Keyword(s):

Phospholipase A2 ◽

Cytosolic Phospholipase A2 ◽

Pivotal Role ◽

U937 Cells ◽

Cytosolic Phospholipase

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p38 kinase/cytosolic phospholipase A2/cyclooxygenase-2 pathway: A new signaling cascade for lipopolysaccharide-induced interleukin-1β and interleukin-6 release in differentiated U937 cells

Prostaglandins & Other Lipid Mediators ◽

10.1016/j.prostaglandins.2008.03.002 ◽

2008 ◽

Vol 86 (1-4) ◽

pp. 61-67 ◽

Cited By ~ 16

Author(s):

Xiaohui Wang ◽

Hui Xue ◽

Quangang Xu ◽

Kai Zhang ◽

Xiuhua Hao ◽

...

Keyword(s):

Phospholipase A2 ◽

Interleukin 6 ◽

Cytosolic Phospholipase A2 ◽

Cyclooxygenase 2 ◽

Interleukin 1Β ◽

Signaling Cascade ◽

U937 Cells ◽

P38 Kinase ◽

Cytosolic Phospholipase

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Characterisation of cytosolic phospholipase A2 as mediator of the enhanced arachidonic acid release from dimethyl sulphoxide differentiated U937 cells

Biochemical Pharmacology ◽

10.1016/0006-2952(95)02084-5 ◽

1995 ◽

Vol 50 (11) ◽

pp. 1893-1902 ◽

Cited By ~ 16

Author(s):

Michael T. Withnall ◽

Andrea Pennington ◽

David Wiseman

Keyword(s):

Arachidonic Acid ◽

Phospholipase A2 ◽

Cytosolic Phospholipase A2 ◽

Dimethyl Sulphoxide ◽

U937 Cells ◽

Arachidonic Acid Release ◽

Cytosolic Phospholipase ◽

Acid Release

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A downstream role for protein kinase Cα in the cytosolic phospholipase A2-dependent protective signalling mediated by peroxynitrite in U937 cells

Biochemical Pharmacology ◽

10.1016/j.bcp.2005.02.002 ◽

2005 ◽

Vol 69 (8) ◽

pp. 1275-1286 ◽

Cited By ~ 16

Author(s):

Andrea Guidarelli ◽

Liana Cerioni ◽

Ilaria Tommasini ◽

Bernhard Brüne ◽

Orazio Cantoni

Keyword(s):

Protein Kinase ◽

Phospholipase A2 ◽

Cytosolic Phospholipase A2 ◽

U937 Cells ◽

Cytosolic Phospholipase ◽

Protein Kinase Cα

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Differential involvement of protein kinase C in activating cytosolic phospholipase A2 in alveolar macrophages and monocyte differentiated U937 cells

Inflammation Research ◽

10.1007/bf01778301 ◽

1995 ◽

Vol 44 (S2) ◽

pp. S139-S140 ◽

Cited By ~ 1

Author(s):

M. T. Withnall ◽

A. M. Pennington ◽

M. Hagen

Keyword(s):

Protein Kinase C ◽

Protein Kinase ◽

Phospholipase A2 ◽

Alveolar Macrophages ◽

Cytosolic Phospholipase A2 ◽

U937 Cells ◽

Cytosolic Phospholipase ◽

Kinase C ◽

Differential Involvement

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A pivotal role of cytosolic phospholipase A2 in bleomycin-induced pulmonary fibrosis

Nature Medicine ◽

10.1038/nm0502-480 ◽

2002 ◽

Vol 8 (5) ◽

pp. 480-484 ◽

Cited By ~ 118

Author(s):

Takahide Nagase ◽

Naonori Uozumi ◽

Satoshi Ishii ◽

Yoshihiro Kita ◽

Hiroshi Yamamoto ◽

...

Keyword(s):

Pulmonary Fibrosis ◽

Phospholipase A2 ◽

Cytosolic Phospholipase A2 ◽

Pivotal Role ◽

Cytosolic Phospholipase

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Cytosolic phospholipase A2 from U937 cells: Size of the functional enzyme by radiation inactivation

Biochemical and Biophysical Research Communications ◽

10.1016/0006-291x(92)91617-y ◽

1992 ◽

Vol 183 (1) ◽

pp. 121-127 ◽

Cited By ~ 10

Author(s):

Nathalie M. Tremblay ◽

Donald Nicholson ◽

Michel Potier ◽

Philip K. Weech

Keyword(s):

Phospholipase A2 ◽

Cytosolic Phospholipase A2 ◽

U937 Cells ◽

Radiation Inactivation ◽

Cytosolic Phospholipase

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Differentiation of U937 Cells Enables a Phospholipase D-Dependent Pathway of Cytosolic Phospholipase A2 Activation

Biochemical and Biophysical Research Communications ◽

10.1006/bbrc.1999.0887 ◽

1999 ◽

Vol 260 (1) ◽

pp. 232-239 ◽

Cited By ~ 12

Author(s):

James R. Burke ◽

Lynda B. Davern ◽

Kurt R. Gregor ◽

Lisa M. Owczarczak

Keyword(s):

Phospholipase A2 ◽

Phospholipase D ◽

Cytosolic Phospholipase A2 ◽

U937 Cells ◽

Cytosolic Phospholipase ◽

Dependent Pathway

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The Ca2(+)-sensitive cytosolic phospholipase A2 is a 100-kDa protein in human monoblast U937 cells.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)67782-3 ◽

1991 ◽

Vol 266 (8) ◽

pp. 5268-5272 ◽

Cited By ~ 5

Author(s):

R M Kramer ◽

E F Roberts ◽

J Manetta ◽

J E Putnam

Keyword(s):

Phospholipase A2 ◽

Cytosolic Phospholipase A2 ◽

U937 Cells ◽

Cytosolic Phospholipase

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Phosphorylation and calcium influx are not sufficient for the activation of cytosolic phospholipase A2 in U937 cells: Requirement for a Giα-type G-protein

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology ◽

10.1016/s0167-4838(97)00085-x ◽

1997 ◽

Vol 1341 (2) ◽

pp. 223-237 ◽

Cited By ~ 30

Author(s):

James R Burke ◽

Lynda B Davern ◽

Kurt R Gregor ◽

Gordon Todderud ◽

Julie G Alford ◽

...

Keyword(s):

Phospholipase A2 ◽

G Protein ◽

Calcium Influx ◽

Cytosolic Phospholipase A2 ◽

U937 Cells ◽

Cytosolic Phospholipase

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Peroxynitrite stimulates the activity of cytosolic phospholipase A2 in U937 cells: the extent of arachidonic acid formation regulates the balance between cell survival or death

Cell Death and Differentiation ◽

10.1038/sj.cdd.4401123 ◽

2002 ◽

Vol 9 (12) ◽

pp. 1368-1376 ◽

Cited By ~ 27

Author(s):

I Tommasini ◽

P Sestili ◽

A Guidarelli ◽

O Cantoni

Keyword(s):

Arachidonic Acid ◽

Phospholipase A2 ◽

Cell Survival ◽

Cytosolic Phospholipase A2 ◽

Acid Formation ◽

U937 Cells ◽

Cytosolic Phospholipase

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