The Environmental Pollutant 1,1-Dichloro-2,2-bis (p-chlorophenyl)ethylene Induces Rat Hepatic Cytochrome P450 2B and 3A Expression through the Constitutive Androstane Receptor and Pregnane X Receptor

2003 ◽  
Vol 64 (2) ◽  
pp. 474-481 ◽  
Author(s):  
Michael E. Wyde ◽  
Erika Bartolucci ◽  
Akiko Ueda ◽  
He Zhang ◽  
Binfang Yan ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Constitutive Androstane Receptor ◽  
Pregnane X Receptor ◽  
Environmental Pollutant ◽  
Hepatic Cytochrome

Antimalarial Artemisinin Drugs Induce Cytochrome P450 and MDR1 Expression by Activation of Xenosensors Pregnane X Receptor and Constitutive Androstane Receptor

2005 ◽  
Vol 67 (6) ◽  
pp. 1954-1965 ◽  
Author(s):  
Oliver Burk ◽  
Katja A. Arnold ◽  
Andreas K. Nussler ◽  
Elke Schaeffeler ◽  
Ekaterina Efimova ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Constitutive Androstane Receptor ◽  
Pregnane X Receptor ◽  
Mdr1 Expression

scholarly journals Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway

2008 ◽  
Vol 417 (1) ◽  
pp. 43-58 ◽  
Author(s):  
Robert D. Finn ◽  
Colin J. Henderson ◽  
Claire L. Scott ◽  
C. Roland Wolf
Keyword(s):  
Cytochrome P450 ◽  
Fatty Acid ◽  
Unsaturated Fatty Acid ◽  
Unsaturated Fatty Acids ◽  
Constitutive Androstane Receptor ◽  
Pregnane X Receptor ◽  
Xenobiotic Metabolism ◽  
Environmental Chemicals ◽  
Liver Growth ◽  
P450 Expression

The liver is responsible for key metabolic functions, including control of normal homoeostasis in response to diet and xenobiotic metabolism/detoxification. We have shown previously that inactivation of the hepatic cytochrome P450 system through conditional deletion of POR (P450 oxidoreductase) induces hepatic steatosis, liver growth and P450 expression. We have exploited a new conditional model of POR deletion to investigate the mechanism underlying these changes. We demonstrate that P450 induction, liver growth and hepatic triacylglycerol (triglyceride) homoeostasis are intimately linked and provide evidence that the observed phenotypes result from hepatic accumulation of unsaturated fatty acids, which mediate these phenotypes by activation of the nuclear receptor CAR (constitutive androstane receptor) and, to a lesser degree, PXR (pregnane X receptor). To our knowledge this is the first direct evidence that P450s play a major role in controlling unsaturated fatty acid homoeostasis via CAR. The regulation of P450s involved in xenobiotic metabolism by this mechanism has potentially significant implications for individual responses to drugs and environmental chemicals.

scholarly journals Thalidomide Increases Human Hepatic Cytochrome P450 3A Enzymes by Direct Activation of the Pregnane X Receptor

2014 ◽  
Vol 27 (2) ◽  
pp. 304-308 ◽  
Author(s):  
Norie Murayama ◽  
Rinie van Beuningen ◽  
Hiroshi Suemizu ◽  
Christiane Guguen-Guillouzo ◽  
Norio Shibata ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Pregnane X Receptor ◽  
Cytochrome P450 3A ◽  
Direct Activation ◽  
Hepatic Cytochrome

Identification of the major human hepatic cytochrome P450 involved in activation and N-dechloroethylation of ifosfamide

1994 ◽  
Vol 47 (7) ◽  
pp. 1157-1163 ◽  
Author(s):  
Dianne Walker ◽  
Jean-Pierre Flinois ◽  
Sophia C. Monkman ◽  
Claire Beloc ◽  
Alan V. Boddy ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Hepatic Cytochrome

scholarly journals Inhibition of hepatic cytochrome P450 enzymes and sodium/bile acid cotransporter exacerbates leflunomide-induced hepatotoxicity

2016 ◽  
Vol 37 (3) ◽  
pp. 415-424 ◽  
Author(s):  
Lei-lei Ma ◽  
Zhi-tao Wu ◽  
Le Wang ◽  
Xue-feng Zhang ◽  
Jing Wang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Bile Acid ◽  
Cytochrome P450 Enzymes ◽  
Hepatic Cytochrome
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