Anti-Inflammatory Activity of 15-Deoxy-Δ12,14-PGJ2and 2-Cyclopenten-1-one: Role of the Heat Shock Response

2003 ◽  
Vol 64 (1) ◽  
pp. 85-93 ◽  
Author(s):  
Angela Ianaro ◽  
Armando Ialenti ◽  
Pasquale Maffia ◽  
Paola Di Meglio ◽  
Massimo Di Rosa ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Response ◽  
Inflammatory Activity ◽  
Shock Response ◽  
Anti Inflammatory

scholarly journals An important role of the heat shock response in infected cells for replication of baculoviruses

Virology ◽  
2010 ◽  
Vol 406 (2) ◽  
pp. 336-341 ◽  
Author(s):  
Yulia V. Lyupina ◽  
Svetlana B. Dmitrieva ◽  
Anna V. Timokhova ◽  
Svetlana N. Beljelarskaya ◽  
Olga G. Zatsepina ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Response ◽  
Shock Response ◽  
Infected Cells

scholarly journals Role of BRCA1 in heat shock response

Oncogene ◽  
2003 ◽  
Vol 22 (1) ◽  
pp. 10-27 ◽  
Author(s):  
Yong Xian Ma ◽  
Saijun Fan ◽  
Jingbo Xiong ◽  
Ren-qi Yuan ◽  
Qinghui Meng ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Response ◽  
Shock Response

scholarly journals Role of HSF1 phopshorylation in heat shock response

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Marek Andrzej Budzyñski ◽  
Mikael Puustien ◽  
Jenny Joutsen ◽  
Julis Anckar ◽  
Lea Sistonen
Keyword(s):  
Heat Shock ◽  
Heat Shock Response ◽  
Shock Response

Poly(ADP-ribosyl)ation regulates heat shock factor-1 activity and the heat shock response in murine fibroblasts

2006 ◽  
Vol 84 (5) ◽  
pp. 703-712 ◽  
Author(s):  
Silvia Fossati ◽  
Laura Formentini ◽  
Zhao-Qi Wang ◽  
Flavio Moroni ◽  
Alberto Chiarugi
Keyword(s):  
Heat Shock ◽  
Heat Shock Response ◽  
Mammalian Cells ◽  
Molecular Mechanisms ◽  
Heat Shock Factor ◽  
Binding Motif ◽  
Heat Shock Factor 1 ◽  
Shock Response ◽  
Parp 1

Poly(ADP-ribose) polymerase-1 (PARP-1)-dependent poly(ADP-ribose) formation is emerging as a key regulator of transcriptional regulation, even though the targets and underlying molecular mechanisms have not yet been clearly identified. In this study, we gathered information on the role of PARP-1 activity in the heat shock response of mouse fibroblasts. We show that DNA binding of heat shock factor (HSF)-1 was impaired by PARP-1 activity in cellular extracts, and was higher in PARP-1−/− than in PARP-1+/+ cells. No evidence for HSF-1 poly(ADP-ribosyl)ation or PARP-1 interaction was found, but a poly(ADP-ribose) binding motif was identified in the transcription factor amino acid sequence. Consistent with data on HSF-1, the expression of heat-shock protein (HSP)-70 and HSP–27 was facilitated in cells lacking PARP-1. Thermosensitivity, however, was higher in PARP-1−/− than in PARP-1+/+ cells. Accordingly, we report that heat-shocked PARP-1 null fibroblasts showed an increased activation of proapoptotic JNK and decreased transcriptional efficiency of prosurvival NF-κB compared with wild-type counterparts. The data indicate that poly(ADP-ribosyl)ation finely regulates HSF-1 activity, and emphasize the complex role of PARP-1 in the heat-shock response of mammalian cells.

The heat shock response in FAP: the role of the extracellular chaperone clusterin

Amyloid ◽  
2012 ◽  
Vol 19 (sup1) ◽  
pp. 3-4 ◽  
Author(s):  
Joana Magalhães ◽  
Maria João Saraiva
Keyword(s):  
Heat Shock ◽  
Heat Shock Response ◽  
Shock Response ◽  
Extracellular Chaperone
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