Jesterone Dimer, a Synthetic Derivative of the Fungal Metabolite Jesterone, Blocks Activation of Transcription Factor Nuclear Factor κB by Inhibiting the Inhibitor of κB Kinase

2003 ◽  
Vol 64 (1) ◽  
pp. 123-131 ◽  
Author(s):  
Mei-Chih Liang ◽  
Sujata Bardhan ◽  
Chaomin Li ◽  
Emily A. Pace ◽  
John A. Porco ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Fungal Metabolite ◽  
Activation Of Transcription ◽  
Synthetic Derivative ◽  
Transcription Factor Nuclear Factor

scholarly journals NFAT5 Contributes to Osmolality-Induced MCP-1 Expression in Mesothelial Cells

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Christoph Küper ◽  
Franz-X. Beck ◽  
Wolfgang Neuhofer
Keyword(s):  
Transcription Factor ◽  
Mesothelial Cell ◽  
Nuclear Factor Κb ◽  
Mesothelial Cells ◽  
Nuclear Factor ◽  
Peritoneal Fibrosis ◽  
Activated T Cells ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Transcription Factor Nuclear Factor

Increased expression of the C-C chemokine monocyte chemoattractant protein-1 (MCP-1) in mesothelial cells in response to high glucose concentrations and/or high osmolality plays a crucial role in the development of peritoneal fibrosis during continuous ambulatory peritoneal dialysis (CAPD). Recent studies suggest that in kidney cells osmolality-induced MCP-1 upregulation is mediated by the osmosensitive transcription factor, nuclear factor of activated T cells 5 (NFAT5). The present study addressed the question of whether activation of NFAT5 by hyperosmolality, as present in PD fluids, contributes to MCP-1 expression in the mesothelial cell line Met5A. Hyperosmolality, induced by addition of glucose, NaCl, or mannitol to the growth medium, increased NFAT5 activity and stimulated MCP-1 expression in Met5A cells. siRNA-mediated knockdown of NFAT5 attenuated osmolality-induced MCP-1 upregulation substantially. Hyperosmolality also induced activation of nuclear factor-κB (NF-κB). Accordingly, pharmacological inhibition of NF-κB significantly decreased osmolality-induced MCP-1 expression. Taken together, these results indicate that high osmolalities activate the transcription factor NFAT5 in mesothelial cells. NFAT5 in turn upregulates MCP-1, likely in combination with NF-κB, and thus may participate in the development of peritoneal fibrosis during CAPD.

Expression of Activated Transcription Factor Nuclear Factor-κB in Periodontally Diseased Tissues

2005 ◽  
Vol 76 (7) ◽  
pp. 1148-1153 ◽  
Author(s):  
R. Ambili ◽  
W.S. Santhi ◽  
Prasanthila Janam ◽  
K. Nandakumar ◽  
M. Radhakrishna Pillai
Keyword(s):  
Transcription Factor ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Transcription Factor Nuclear Factor

Inhibition of the transcription factor nuclear factor-κB by adenoviral-mediated expression of IκBαM results in tumor cell death

Surgery ◽  
1999 ◽  
Vol 126 (2) ◽  
pp. 399-405 ◽  
Author(s):  
Barry W. Feig ◽  
Xiaolin Lu ◽  
Kelly K. Hunt ◽  
Qin Shan ◽  
Dihua Yu ◽  
...  
Keyword(s):  
Cell Death ◽  
Transcription Factor ◽  
Tumor Cell ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Tumor Cell Death ◽  
Transcription Factor Nuclear Factor

scholarly journals Activation of the transcription factor nuclear factor-κB in human inflamed synovial tissue

1996 ◽  
Vol 39 (4) ◽  
pp. 583-591 ◽  
Author(s):  
R. Marok ◽  
P. G. Winyard ◽  
A. Coumbe ◽  
M. L. Kus ◽  
K. Gaffney ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Synovial Tissue ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Transcription Factor Nuclear Factor
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