scholarly journals Regulation of G Protein-Coupled Receptor Kinases and Arrestins During Receptor Desensitization

2003 ◽  
Vol 63 (1) ◽  
pp. 9-18 ◽  
Author(s):  
Trudy A. Kohout ◽  
Robert J. Lefkowitz
Keyword(s):  
G Protein ◽  
Receptor Desensitization ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
G Protein Coupled

scholarly journals Histamine H2 Receptor Desensitization: Involvement of a Select Array of G Protein-Coupled Receptor Kinases

2001 ◽  
Vol 60 (5) ◽  
pp. 1049-1056 ◽  
Author(s):  
Carina Shayo ◽  
Natalia Fernandez ◽  
Bibiana Lemos Legnazzi ◽  
Federico Monczor ◽  
Alejandro Mladovan ◽  
...  
Keyword(s):  
G Protein ◽  
Receptor Desensitization ◽  
G Protein Coupled Receptor ◽  
Histamine H2 Receptor ◽  
H2 Receptor ◽  
Receptor Kinases ◽  
G Protein Coupled

Pleiotropic Role for GRKs and b-Arrestins in Receptor Regulation

Physiology ◽  
1997 ◽  
Vol 12 (4) ◽  
pp. 145-152 ◽  
Author(s):  
SSG Ferguson ◽  
J Zhang ◽  
LS Barak ◽  
MG Caron
Keyword(s):  
Angiotensin Ii ◽  
G Protein ◽  
Intracellular Trafficking ◽  
Coated Vesicle ◽  
Receptor Regulation ◽  
Receptor Desensitization ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
Trafficking Molecules ◽  
G Protein Coupled

G protein-coupled receptor kinases and arrestin proteins are well-characterized mediators of agonist-dependent G protein-coupled receptor desensitization. These proteins are now shown to play a dual role in receptor regulation by mediating both receptor uncoupling and sequestration, a process important for receptor resensitization. b-Arrestins bound to phosporylated b2-adrenergic and angiotensin II type 1A receptors act as intracellular trafficking molecules specifically targeting these receptors for dynamin-dependent clathrin-coated vesicle-mediated sequestration.

scholarly journals Role of G Protein–Coupled Receptor Kinases 2 and 3 in μ-Opioid Receptor Desensitization and Internalization

2015 ◽  
Vol 88 (2) ◽  
pp. 347-356 ◽  
Author(s):  
Janet D. Lowe ◽  
Helen S. Sanderson ◽  
Alexandra E. Cooke ◽  
Mehrnoosh Ostovar ◽  
Elena Tsisanova ◽  
...  
Keyword(s):  
G Protein ◽  
Opioid Receptor ◽  
Receptor Desensitization ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
Μ Opioid Receptor ◽  
G Protein Coupled

scholarly journals The G Protein-Coupled Receptor Kinases (GRKs) in Chemokine Receptor-Mediated Immune Cell Migration: From Molecular Cues to Physiopathology

Cells ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 75
Author(s):  
Marta Laganà ◽  
Géraldine Schlecht-Louf ◽  
Françoise Bachelerie
Keyword(s):  
G Protein ◽  
Chemokine Receptor ◽  
Immune Cell ◽  
Neutrophil Migration ◽  
G Protein Coupled Receptor ◽  
Receptor Kinases ◽  
Immune Cell Migration ◽  
And Migration ◽  
G Protein Coupled ◽  
Gpcr Desensitization

Although G protein-coupled receptor kinases (GRKs) have long been known to regulate G protein-coupled receptor (GPCR) desensitization, their more recently characterized functions as scaffolds and signalling adapters underscore that this small family of proteins governs a larger array of physiological functions than originally suspected. This review explores how GRKs contribute to the complex signalling networks involved in the migration of immune cells along chemokine gradients sensed by cell surface GPCRs. We outline emerging evidence indicating that the coordinated docking of several GRKs on an active chemokine receptor determines a specific receptor phosphorylation barcode that will translate into distinct signalling and migration outcomes. The guidance cues for neutrophil migration are emphasized based on several alterations affecting GRKs or GPCRs reported to be involved in pathological conditions.

Correlation Between Beta-Adrenoceptors and G-Protein-Coupled Receptor Kinases in Pretransplantation Heart Failure

2008 ◽  
Vol 40 (9) ◽  
pp. 3014-3016 ◽  
Author(s):  
J. Agüero ◽  
L. Almenar ◽  
P. D'Ocon ◽  
E. Oliver ◽  
F. Montó ◽  
...  
Keyword(s):  
Heart Failure ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Beta Adrenoceptors ◽  
Receptor Kinases ◽  
G Protein Coupled
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