Identification of Interaction Sites of Cyclic Nucleotide Phosphodiesterase Type 3A with Milrinone and Cilostazol Using Molecular Modeling and Site-Directed Mutagenesis

2002 ◽  
Vol 62 (3) ◽  
pp. 514-520 ◽  
Author(s):  
W. Zhang ◽  
H. Ke ◽  
R. W. Colman
Keyword(s):  
Molecular Modeling ◽  
Cyclic Nucleotide ◽  
Site Directed Mutagenesis ◽  
Cyclic Nucleotide Phosphodiesterase ◽  
Directed Mutagenesis ◽  
Interaction Sites ◽  
Phosphodiesterase Type

Two Substrate Interaction Sites in Lignin Peroxidase Revealed by Site-Directed Mutagenesis†

Biochemistry ◽  
1998 ◽  
Vol 37 (43) ◽  
pp. 15097-15105 ◽  
Author(s):  
Wendy A. Doyle ◽  
Wolfgang Blodig ◽  
Nigel C. Veitch ◽  
Klaus Piontek ◽  
Andrew T. Smith
Keyword(s):  
Lignin Peroxidase ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Interaction Sites ◽  
Substrate Interaction

scholarly journals Identification of essential residues for binding and activation in the human 5-HT7(a) serotonin receptor by molecular modeling and site-directed mutagenesis

2015 ◽  
Vol 9 ◽  
Author(s):  
Agata Antonina Rita Impellizzeri ◽  
Matteo Pappalardo ◽  
Livia Basile ◽  
Ornella Manfra ◽  
Kjetil Wessel Andressen ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Serotonin Receptor ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis

Combination of Molecular Modeling, Site-Directed Mutagenesis, and SAR Studies To Delineate the Binding Site of Pyridopyrimidine Antagonists on the Human CCK1 Receptor

2005 ◽  
Vol 48 (15) ◽  
pp. 4842-4850 ◽  
Author(s):  
Mercedes Martín-Martínez ◽  
Anne Marty ◽  
Maud Jourdan ◽  
Chantal Escrieut ◽  
Elodie Archer ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Binding Site ◽  
Site Directed Mutagenesis ◽  
Directed Mutagenesis ◽  
Sar Studies ◽  
Cck1 Receptor

Cyclic nucleotide phosphodiesterase type 4 inhibitors: Evaluation of pyrazolo[1,5-a]-1,3,5-triazine ring system as an adenine bioisostere

2008 ◽  
Vol 43 (4) ◽  
pp. 816-829 ◽  
Author(s):  
Pierre Raboisson ◽  
Dominique Schultz ◽  
Christian Muller ◽  
Jean-Marie Reimund ◽  
Guillaume Pinna ◽  
...  
Keyword(s):  
Cyclic Nucleotide ◽  
Ring System ◽  
Cyclic Nucleotide Phosphodiesterase ◽  
Triazine Ring ◽  
Phosphodiesterase Type
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