Regulation of Dopamine D1 Receptor Trafficking by Protein Kinase A-Dependent Phosphorylation

2002 ◽  
Vol 61 (4) ◽  
pp. 806-816 ◽  
Author(s):  
John N. Mason ◽  
Laura B. Kozell ◽  
Kim A. Neve
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Receptor Trafficking ◽  
Kinase A

In vivo andin vitro ethanol exposure in prenatal rat brain: GABAB receptor modulation on dopamine D1 receptor and protein kinase A

Synapse ◽  
2008 ◽  
Vol 62 (7) ◽  
pp. 534-543 ◽  
Author(s):  
H.Y. Lee ◽  
N. Naha ◽  
S.P. Li ◽  
M.J. Jo ◽  
M.L. Naseer ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Rat Brain ◽  
Gabab Receptor ◽  
Ethanol Exposure ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Receptor Modulation ◽  
Kinase A

scholarly journals Role of Aberrant Striatal Dopamine D1 Receptor/cAMP/Protein Kinase A/DARPP32 Signaling in the Paradoxical Calming Effect of Amphetamine

2010 ◽  
Vol 30 (33) ◽  
pp. 11043-11056 ◽  
Author(s):  
F. Napolitano ◽  
A. Bonito-Oliva ◽  
M. Federici ◽  
M. Carta ◽  
F. Errico ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Dopamine D1 Receptor ◽  
D1 Receptor ◽  
Striatal Dopamine ◽  
Calming Effect ◽  
Kinase A

cAMP-independent, G protein-linked inhibition of Na+/H+ exchange in renal brush border by D1 dopamine agonists

1993 ◽  
Vol 264 (6) ◽  
pp. F1032-F1037 ◽  
Author(s):  
C. C. Felder ◽  
F. E. Albrecht ◽  
T. Campbell ◽  
G. M. Eisner ◽  
P. A. Jose
Keyword(s):  
Protein Kinase ◽  
Protein Kinase A ◽  
Adenylyl Cyclase ◽  
G Proteins ◽  
Dopamine Agonists ◽  
D1 Receptor ◽  
D1 Dopamine Agonists ◽  
Kinase A ◽  
Exchange Activity

When D1 dopamine agonists are incubated with renal cortical tissue, Na+/H+ exchange activity is inhibited, presumably due to D1 receptor-mediated stimulation of adenylyl cyclase and subsequent increase in protein kinase A activity. Although the role of adenosine 3',5'-cyclic monophosphate (cAMP) and cAMP-dependent protein kinase in the regulation of Na+/H+ exchange activity is well established, receptors functionally coupled to adenylyl cyclase can regulate Na+/H+ exchange activity independently of changes of cAMP accumulation. The current studies were designed to determine whether D1 agonists can inhibit Na+/H+ exchange activity independently of changes of cAMP accumulation and also to determine the role of G proteins in this process. The D1 agonist, fenoldopam, inhibited Na+/H+ exchange activity in a time-related and concentration-dependent manner. The 50% inhibitory concentration was 5-34 microM. Occupation of the renal D1 receptor mediates this action, since the D1 antagonist, SKF 83742, partially blocks the effect. This action, however, was independent of adenylyl cyclase, protein kinase A, and protein kinase C activity. Inhibition of adenylyl cyclase with dideoxyadenosine or inhibition of protein kinase A and C with the isoquinolines N-(2-guanidinoethyl)-5-isoquinolinesulfonamide hydrochloride (H-4) and 1-(5-isoquinolinesfulfonyl)-2-methylpiperazine (H-7) did not block the effect of fenoldopam on the exchanger. The action of fenoldopam is not due to an amiloride-like action on the exchanger, because kinetic analysis of the inhibitory action was noncompetitive and the effect of fenoldopam was time dependent. The process involved G proteins, since guanosine 5'-O-(2-thiodiphosphate) prevented while guanosine 5'-O-(3-thiotriphosphate) increased the inhibitory effect of fenoldopam.

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