Synthesis and Evaluation of a New Class of Nifedipine Analogs with T-Type Calcium Channel Blocking Activity

2002 ◽  
Vol 61 (3) ◽  
pp. 649-658 ◽  
Author(s):  
P. Phani Kumar ◽  
Stephanie C. Stotz ◽  
R. Paramashivappa ◽  
Aaron M. Beedle ◽  
Gerald W. Zamponi ◽  
...  
Keyword(s):  
Calcium Channel ◽  
New Class ◽  
Channel Blocking ◽  
Blocking Activity

Synthesis of Hexahydro-1H-pyrido[3,2-c]azepines as Hypotensive Agents of Expected Calcium-Channel Blocking Activity

2007 ◽  
Vol 138 (3) ◽  
pp. 219-225 ◽  
Author(s):  
Mohamed E. El-Sadek ◽  
Mansour Aboukull ◽  
Osama I. El-Sabbagh ◽  
Hassan M. Shallal
Keyword(s):  
Calcium Channel ◽  
Channel Blocking ◽  
Blocking Activity

Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity

2010 ◽  
Vol 18 (16) ◽  
pp. 5938-5944 ◽  
Author(s):  
Yoo Lim Kam ◽  
Hee-Kyung Rhee ◽  
Hyewhon Rhim ◽  
Seung Keun Back ◽  
Heung Sik Na ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Analgesic Activity ◽  
Channel Blocking ◽  
Blocking Activity

scholarly journals Differential Antifungal and Calcium Channel-Blocking Activity among Structurally Related Plant Defensins

2004 ◽  
Vol 135 (4) ◽  
pp. 2055-2067 ◽  
Author(s):  
Robert G. Spelbrink ◽  
Nejmi Dilmac ◽  
Aron Allen ◽  
Thomas J. Smith ◽  
Dilip M. Shah ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Plant Defensins ◽  
Channel Blocking ◽  
Blocking Activity ◽  
Related Plant

Synthesis and Calcium Channel Blocking Activity of 4-Indolyl-1,4-dihydropyridines

1997 ◽  
Vol 25 (3) ◽  
pp. 169-178 ◽  
Author(s):  
Rodolfo Lavilla ◽  
Teresa Gotsens ◽  
M.Carmen Santano ◽  
Joan Bosch ◽  
Antoni Camins ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Channel Blocking ◽  
Blocking Activity

Lipophilic amino alcohols with calcium channel blocking activity

1992 ◽  
Vol 44 (10) ◽  
pp. 2039-2046 ◽  
Author(s):  
Anil S. Sipahimalani ◽  
John L. Werth ◽  
Robert H. Michelson ◽  
Aloke K. Dutta ◽  
S.Mbua N. Efange ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Amino Alcohols ◽  
Channel Blocking ◽  
Blocking Activity

scholarly journals Cardiodepressant Activity of Newer Dihydropyrimidine Derivative in Comparison to Nifedipine on Perfused Rabbits Heart

2012 ◽  
Vol 1 (2) ◽  
pp. 6
Author(s):  
R. Kumar ◽  
V. K. Sehgal ◽  
B. Kaur ◽  
R. Kaur
Keyword(s):  
Calcium Channel ◽  
Coronary Flow ◽  
Negative Inotropic Effect ◽  
Channel Blockers ◽  
Test Compound ◽  
Channel Blocking ◽  
Blocking Activity ◽  
The Status ◽  
Tissue Models ◽  
Dose Dependent

<p><strong>Background</strong>: Substituted dihydropyridine calcium channel blockers are used in the treatment of cardiovascular diseases. Dihydropyridines are considered as analogue of dihydropyrimidines.</p><p><strong>Objectives</strong>: In present study newly synthesized test compound 5- Acyl-6-methyl-4(2',3'-methylenedioxy) phenyl - 2 - S - ethyl - 1, 4- dihydropyrimidine, a dihydropyrimidine derivative was investigated with an aim to get valuable substitute for the well known dihydropyridine, Nifedipine.</p><p><strong>Material &amp; Methods</strong>: The Calcium Channel blocking actiuity of test compound was studied on Rabbit's Heart and its effects were compared with Nifedipine used as control.</p><p><strong>Results</strong>: Test compound has dose-dependent negative chronotropic and negative inotropic effect on Rabbit's heart but these effects appeared at doses higher than those of Nifedipine. Test compound had no significant change in coronary flow however Nifedipine show significant increase in coronary flow at lower doses.</p><p><strong>Conclusion</strong>: Test compound appears to be less potent myocardial depressant compared to Nifedipine. Test compound produced calcium channel blocking activity which was dose related and in order to ascertain the status of this compound as a drug, further studies are needed not only in other animals and tissue models but also in various pathophysiological models.</p>

Calcium channel blocking activity: Screening methods for plant derived compounds

Phytomedicine ◽  
1997 ◽  
Vol 4 (2) ◽  
pp. 167-180 ◽  
Author(s):  
H. Vuorela ◽  
P. Vuorela ◽  
K. Törnquist ◽  
S. Alaranta
Keyword(s):  
Calcium Channel ◽  
Screening Methods ◽  
Channel Blocking ◽  
Blocking Activity ◽  
Activity Screening
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