Human Group IIA Secretory Phospholipase A2 Induces Neuronal Cell Death via Apoptosis

2002 ◽  
Vol 61 (1) ◽  
pp. 114-126 ◽  
Author(s):  
Tatsurou Yagami ◽  
Keiichi Ueda ◽  
Kenji Asakura ◽  
Satoshi Hata ◽  
Takayuki Kuroda ◽  
...  
Keyword(s):  
Cell Death ◽  
Phospholipase A2 ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Secretory Phospholipase A2 ◽  
Human Group ◽  
Secretory Phospholipase

Secretory phospholipase A2 potentiates glutamate-induced rat striatal neuronal cell death in vivo

1999 ◽  
Vol 274 (3) ◽  
pp. 167-170 ◽  
Author(s):  
Miriam Kolko ◽  
Torben Bruhn ◽  
Thomas Christensen ◽  
Michel Lazdunski ◽  
Gérard Lambeau ◽  
...  
Keyword(s):  
Cell Death ◽  
Phospholipase A2 ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Secretory Phospholipase A2 ◽  
Secretory Phospholipase

Secretory phospholipase A2-mediated neuronal cell death involves glutamate ionotropic receptors

Neuroreport ◽  
2002 ◽  
Vol 13 (15) ◽  
pp. 1963-1966 ◽  
Author(s):  
Miriam Kolko ◽  
Elena B. Rodriguez de Turco ◽  
Nils Henrik Diemer ◽  
Nicolas G. Bazan
Keyword(s):  
Cell Death ◽  
Phospholipase A2 ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Secretory Phospholipase A2 ◽  
Ionotropic Receptors ◽  
Secretory Phospholipase

Group IB secretory phospholipase A2 induces neuronal cell death via apoptosis

2002 ◽  
Vol 81 (3) ◽  
pp. 449-461 ◽  
Author(s):  
Tatsurou Yagami ◽  
Keiichi Ueda ◽  
Kenji Asakura ◽  
Yoko Hayasaki-Kajiwara ◽  
Hitoshi Nakazato ◽  
...  
Keyword(s):  
Cell Death ◽  
Phospholipase A2 ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Secretory Phospholipase A2 ◽  
Secretory Phospholipase

scholarly journals Relationship between membrane permeability and specificity of human secretory phospholipase A2 isoforms during cell death

2011 ◽  
Vol 1808 (7) ◽  
pp. 1913-1920 ◽  
Author(s):  
Jennifer Nelson ◽  
Elizabeth Gibbons ◽  
Katalyn R. Pickett ◽  
Michael Streeter ◽  
Ashley O. Warcup ◽  
...  
Keyword(s):  
Cell Death ◽  
Phospholipase A2 ◽  
Membrane Permeability ◽  
Secretory Phospholipase A2 ◽  
Secretory Phospholipase

scholarly journals Total direct chemical synthesis and biological activities of human group IIA secretory phospholipase A2

2002 ◽  
Vol 365 (2) ◽  
pp. 505-511 ◽  
Author(s):  
Chang-Zhi DONG ◽  
Anthony ROMIEU ◽  
Carine M. MOUNIER ◽  
Françoise HEYMANS ◽  
Bernard P. ROQUES ◽  
...  
Keyword(s):  
Amino Acids ◽  
Chemical Synthesis ◽  
Phospholipase A2 ◽  
Solid Phase ◽  
Biological Activities ◽  
Phase Method ◽  
Secretory Phospholipase A2 ◽  
Human Group ◽  
Recombinant Enzymes ◽  
Secretory Phospholipase

Human group IIA secretory phospholipase A2 (hGIIA sPLA2) is reported to be involved in inflammation, since its expression level is enhanced under various inflammatory conditions. In this work, we report the total chemical synthesis of this enzyme (124 amino acids) by solid-phase method. The identity of the protein, in denatured or folded (7 disulphide bonds) forms, was confirmed by electrospray MS. Synthetic sPLA2 possesses the same circular dichroism spectrum, enzymic activity in hydrolysing different phospholipid substrates, and inhibitory effect in thrombin formation from prothrombinase complex as the recombinant sPLA2. Furthermore, LY311727, a reported specific hGIIA sPLA2 inhibitor, is able to inhibit the synthetic and the recombinant enzymes with the same efficiency. This study demonstrates that chemically continuous solid phase synthesis is an alternative and less time-consuming approach to producing small, structurally folded and fully active proteins of up to 124 amino acids, such as hGIIA sPLA2. Moreover, this technique provides more flexibility in analogue synthesis to elucidate their physiological functions and pathological effects.

Characterization of Monoclonal Antibodies Specific for 14-kDa Human Group V Secretory Phospholipase A2 (hVPLA2)

Hybridoma ◽  
2000 ◽  
Vol 19 (2) ◽  
pp. 171-176 ◽  
Author(s):  
Nilda M. Muñoz ◽  
Kwang Pyo Kim ◽  
Sang Kyo Han ◽  
Evan Boetticher ◽  
Anne I. Sperling ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Phospholipase A2 ◽  
Secretory Phospholipase A2 ◽  
Human Group ◽  
Group V ◽  
Secretory Phospholipase

scholarly journals Biophysical Basis for Specificity of Action of Human Isoforms of Secretory Phospholipase A2 During Cell Death

2011 ◽  
Vol 100 (3) ◽  
pp. 41a
Author(s):  
Jennifer Nelson ◽  
Amanda M. Berbert ◽  
Elizabeth Gibbons ◽  
Katalyn R. Pickett ◽  
Michael Streeter ◽  
...  
Keyword(s):  
Cell Death ◽  
Phospholipase A2 ◽  
Secretory Phospholipase A2 ◽  
Secretory Phospholipase ◽  
Human Isoforms

scholarly journals Role of membrane oxidation in controlling the activity of human group IIa secretory phospholipase A2 toward apoptotic lymphoma cells

2013 ◽  
Vol 1828 (2) ◽  
pp. 670-676 ◽  
Author(s):  
Elizabeth Gibbons ◽  
Jennifer Nelson ◽  
Lynn Anderson ◽  
Kelly Brewer ◽  
Stephanie Melchor ◽  
...  
Keyword(s):  
Phospholipase A2 ◽  
Secretory Phospholipase A2 ◽  
Human Group ◽  
Lymphoma Cells ◽  
Secretory Phospholipase ◽  
Membrane Oxidation
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