Histamine H1-Receptor Activation of Nuclear Factor-κB: Roles for Gβγ- and Gαq/11-Subunits in Constitutive and Agonist-Mediated Signaling

2001 ◽  
Vol 60 (5) ◽  
pp. 1133-1142 ◽  
Author(s):  
Remko A. Bakker ◽  
Stefan B. J. Schoonus ◽  
Martine J. Smit ◽  
Henk Timmerman ◽  
Rob Leurs
Keyword(s):  
Nuclear Factor Κb ◽  
Receptor Activation ◽  
Nuclear Factor ◽  
H1 Receptor ◽  
Histamine H1 Receptor

Linking agonist binding to histamine H1 receptor activation

2005 ◽  
Vol 1 (2) ◽  
pp. 98-103 ◽  
Author(s):  
Aldo Jongejan ◽  
Martijn Bruysters ◽  
Juan A Ballesteros ◽  
Eric Haaksma ◽  
Remko A Bakker ◽  
...  
Keyword(s):  
Receptor Activation ◽  
Agonist Binding ◽  
H1 Receptor ◽  
Histamine H1 Receptor

(R)-α-Methylhistamine augments neural, cholinergic bronchospasm in guinea pigs by histamine H1 receptor activation

1992 ◽  
Vol 211 (3) ◽  
pp. 421-426 ◽  
Author(s):  
John A. Hey ◽  
Maurice del Prado ◽  
Robert W. Egan ◽  
William Kreutner ◽  
Richard W. Chapman
Keyword(s):  
Guinea Pigs ◽  
Receptor Activation ◽  
H1 Receptor ◽  
Histamine H1 Receptor

scholarly journals Lymphotoxin β receptor activation promotes bladder cancer in a nuclear factor-κB-dependent manner

2014 ◽  
Vol 11 (2) ◽  
pp. 783-790 ◽  
Author(s):  
MO SHEN ◽  
XIUZHI DUAN ◽  
PING ZHOU ◽  
WU ZHOU ◽  
XIULING WU ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Nuclear Factor Κb ◽  
Receptor Activation ◽  
Dependent Manner ◽  
Nuclear Factor ◽  
Β Receptor

scholarly journals Histamine H1-receptor-mediated calcium influx in DDT1MF-2 cells

1992 ◽  
Vol 284 (2) ◽  
pp. 425-431 ◽  
Author(s):  
J M Dickenson ◽  
S J Hill
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Cell Line ◽  
Muscle Cell ◽  
Calcium Influx ◽  
Receptor Activation ◽  
Plateau Phase ◽  
H1 Receptor ◽  
Histamine H1 Receptor ◽  
Muscle Cell Line

Undifferentiated monolayers of the hamster vas deferens smooth-muscle cell line, DDT1MF-2, were grown on glass coverslips and loaded with the Ca(2+)-sensitive fluorescent dye fura-2. Stimulation with histamine produced a rapid and maintained increase in intracellular free Ca2+ ([Ca2+]i), with an EC50 of 7.0 +/- 0.7 microM. The initial rise in [Ca2+]i can be attributed to Ca2+ release from intracellular stores, whereas the maintained or plateau phase is due to influx of extracellular Ca2+. The Ca2+ influx associated with the plateau phase required the continued presence of histamine on the receptor, since the H1-antagonist mepyramine (10 microM) attenuated the rise in [Ca2+]i observed when extracellular Ca2+ was re-applied after the cells had been stimulated with histamine, in experiments performed in nominally Ca(2+)-free buffer. Pretreatment with the inorganic Ca(2+)-channel blockers Ni2+ (1 mM) and Co2+ (1 mM) inhibited the influx component, whereas the organic voltage-operated Ca(2+)-channel antagonists nifedipine (10 microM) and PN-200-110 (10 microM) had no effect. These data suggest that histamine stimulates Ca2+ influx through an H1-receptor-activated Ca2+ channel. Experiments with Mn2+ indicated that the receptor-mediated Ca(2+)-influx pathway(s) is impermeable to Mn2+. Furthermore, the refilling of Ca2+ stores can occur independently of H1-receptor-mediated influx, since store refilling can be demonstrated even when the receptor-mediated Ca2+ entry is blocked by mepyramine. In conclusion, H1-receptor activation in the smooth-muscle cell line DDT1MF-2 stimulates both release of Ca2+ from intracellular stores [inositol 1,4,5-triphosphate (InsP3)-mediated] and Ca2+ influx through a receptor-activated Ca2+ channel. The subsequent refilling of the InsP3-sensitive intracellular Ca2+ store is independent of histamine H1-receptor stimulation (mepyramine-insensitive) and occurs without an observable rise in cytosolic free Ca2+.

Sign in / Sign up

Export Citation Format

Share Document