C-Myc Down-Regulation Increases Susceptibility to Cisplatin through Reactive Oxygen Species-Mediated Apoptosis in M14 Human Melanoma Cells

2001 ◽  
Vol 60 (1) ◽  
pp. 174-182 ◽  
Author(s):  
Annamaria Biroccio ◽  
Barbara Benassi ◽  
Sarah Amodei ◽  
Chiara Gabellini ◽  
Donatella Del Bufalo ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Oxygen Species ◽  
Down Regulation ◽  
Human Melanoma Cells

Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2

APOPTOSIS ◽  
2011 ◽  
Vol 16 (10) ◽  
pp. 1014-1027 ◽  
Author(s):  
Eleonore Mayola ◽  
Cindy Gallerne ◽  
Davide Degli Esposti ◽  
Cecile Martel ◽  
Shazib Pervaiz ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Withaferin A ◽  
Oxygen Species ◽  
Down Regulation ◽  
Human Melanoma Cells

scholarly journals Melatonin Induces Melanogenesis in Human SK-MEL-1 Melanoma Cells Involving Glycogen Synthase Kinase-3 and Reactive Oxygen Species

2020 ◽  
Vol 21 (14) ◽  
pp. 4970
Author(s):  
Juan Perdomo ◽  
Carlos Quintana ◽  
Ignacio González ◽  
Inmaculada Hernández ◽  
Sara Rubio ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Glycogen Synthase ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Glycogen Synthase Kinase ◽  
Oxygen Species ◽  
Glycogen Synthase Kinase 3Β ◽  
Human Melanoma Cells

Melatonin is present in all living organisms where it displays a diversity of physiological functions. Attenuation of melanogenesis by melatonin has been reported in some mammals and also in rodent melanoma cells. However, melatonin may also stimulate melanogenesis in human melanoma cells through mechanisms that have not yet been revealed. Using the human melanoma cells SK-MEL-1 as a model, an increase in both tyrosinase activity and melanin was already observed at 24 h after melatonin treatment with maximal levels of both being detected at 72 h. This effect was associated with the induction in the expression of the enzymes involved in the synthesis of melanin. In this scenario, glycogen synthase kinase-3β seems to play a significant function since melatonin decreased its phosphorylation and preincubation with specific inhibitors of this protein kinase (lithium or BIO) reduced the expression and activity of tyrosinase. Blocking of PI3K/AKT pathway stimulated melanogenesis and the effect was suppressed by the inhibitors of glycogen synthase kinase-3β. Although melatonin is a recognized antioxidant, we found that it stimulates reactive oxygen species generation in SK-MEL-1 cells. These chemical species seem to be an important signal in activating the melanogenic process since the antioxidants N-acetyl-l-cysteine and glutathione decreased both the level and activity of tyrosinase stimulated by melatonin. Our results support the view that regulation of melanogenesis involves a cross-talk between several signaling pathways.

Simvastatin rises reactive oxygen species levels and induces senescence in human melanoma cells by activation of p53/p21 pathway

2013 ◽  
Vol 319 (19) ◽  
pp. 2977-2988 ◽  
Author(s):  
Fernanda Augusta de Lima Barbosa Guterres ◽  
Glaucia Regina Martinez ◽  
Maria Eliane Merlin Rocha ◽  
Sheila Maria Brochado Winnischofer
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Oxygen Species ◽  
Human Melanoma Cells

Piperlongumine Induces Apoptosis in Human Melanoma Cells Via Reactive Oxygen Species Mediated Mitochondria Disruption

2018 ◽  
Vol 70 (3) ◽  
pp. 502-511 ◽  
Author(s):  
Xuejiao Song ◽  
Tiantao Gao ◽  
Qian Lei ◽  
Lidan Zhang ◽  
Yuqin Yao ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Oxygen Species ◽  
Human Melanoma Cells
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