Role of Receptor and Protein Kinase C Activation in the Internalization of the Gastrin-Releasing Peptide Receptor

1998 ◽  
Vol 54 (5) ◽  
pp. 889-898 ◽  
Author(s):  
Barbara Y. Williams ◽  
Stéphane B. Dion ◽  
Agnes Schonbrunn
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Peptide Receptor ◽  
Gastrin Releasing Peptide ◽  
Kinase C ◽  
Protein Kinase C Activation

scholarly journals Mechanisms of Cardiac Hypertrophy and Injury. Possible Role of Protein Kinase C Activation.

1991 ◽  
Vol 55 (11) ◽  
pp. 1149-1157 ◽  
Author(s):  
ISSEI KOMURO ◽  
YOUICHI KATOH ◽  
EITETSU HOH ◽  
FUMIMARO TAKAKU ◽  
YOSHIO YAZAKI
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Cardiac Hypertrophy ◽  
Kinase C ◽  
Protein Kinase C Activation

Modification of Na+/H+ Exchanger in Human Platelets by 1,2-Dioctanoylglycerol, a Protein Kinase C Activator

1990 ◽  
Vol 64 (01) ◽  
pp. 165-171 ◽  
Author(s):  
Yukio Ozaki ◽  
Yuki Mastsumoto ◽  
Yutaka Yatomi ◽  
Masaaki Higashihara
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Rate Constant ◽  
Human Platelets ◽  
Kinase C ◽  
Km Value ◽  
The Difference ◽  
The One ◽  
Protein Kinase C Activation

SummaryProtein kinase C activation in human platelets has a modulatory role in maintaining intracellular pH (pHi), by adjusting pHi at a particular value (7.22). Changes in pHi induced by protein kinase C appeared to be dependent upon the difference between H+ efflux catalyzed by the Na+/H+ exchanger and H+ production. The pHi recovery after acid loading was significantly facilitated by protein kinase C activation. Analysis of the rate constant for pHi recovery suggested that the turnover rate or the apparent affinity of the Na+/H+ exchanger for H+ was increased. Protein kinase C also decreased the Km value of the Na+/H+ exchanger for extracellular Na+. Thus, it is suggested that the role of protein kinase C in platelet pHi regulation is dual, adjusting the pHi value at a certain setpoint on the one hand, and increasing the rate constant of the Na+/H+ exchanger on the other.

scholarly journals The Gastrin-releasing Peptide Receptor Is Rapidly Phosphorylated by a Kinase Other Than Protein Kinase C After Exposure to Agonist

1995 ◽  
Vol 270 (14) ◽  
pp. 8217-8224 ◽  
Author(s):  
Glenn S. Kroog ◽  
Eduardo Sainz ◽  
Peter J. Worland ◽  
Mark A. Akeson ◽  
Richard V. Benya ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Peptide Receptor ◽  
Gastrin Releasing Peptide ◽  
Kinase C
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