A Scale of Agonism and Allosteric Modulation for Assessment of Selectivity, Bias, and Receptor Mutation

Terry Kenakin

doi:10.1124/mol.117.108787

A Scale of Agonism and Allosteric Modulation for Assessment of Selectivity, Bias, and Receptor Mutation

Molecular Pharmacology ◽

10.1124/mol.117.108787 ◽

2017 ◽

Vol 92 (4) ◽

pp. 414-424 ◽

Cited By ~ 34

Author(s):

Terry Kenakin

Keyword(s):

Allosteric Modulation ◽

Selectivity Bias

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Correction to “A Scale of Agonism and Allosteric Modulation for Assessment of Selectivity, Bias, and Receptor Mutation”

Molecular Pharmacology ◽

10.1124/mol.117.108787err ◽

2017 ◽

Vol 92 (5) ◽

pp. 501-501

Keyword(s):

Allosteric Modulation ◽

Selectivity Bias

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F557L – a novel determinant of hERG channel inhibition: allosteric modulation or drug binding?

Intrinsic Activity ◽

10.25006/ia.1.s1-a3.12 ◽

2013 ◽

Vol 1 (Suppl. 1) ◽

pp. A3.12

Author(s):

Priyanka Saxena

Keyword(s):

Allosteric Modulation ◽

Drug Binding ◽

Herg Channel ◽

Channel Inhibition

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Faculty Opinions recommendation of Multiple molecular determinants for allosteric modulation of alternatively spliced AMPA receptors.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1002224.201428 ◽

2004 ◽

Author(s):

Eric Nestler

Keyword(s):

Ampa Receptors ◽

Allosteric Modulation ◽

Molecular Determinants ◽

Alternatively Spliced

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Faculty Opinions recommendation of Negative allosteric modulation of nicotinic acetylcholine receptors blocks nicotine self-administration in rats.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1092041.553238 ◽

2007 ◽

Author(s):

Jerry Buccafusco

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Allosteric Modulation ◽

Self Administration ◽

Nicotinic Acetylcholine

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Faculty Opinions recommendation of Allosteric modulation of Ras positions Q61 for a direct role in catalysis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.3001965.2680064 ◽

2010 ◽

Author(s):

Matthias Buck

Keyword(s):

Allosteric Modulation ◽

Direct Role

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Faculty Opinions recommendation of Activation and allosteric modulation of a muscarinic acetylcholine receptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718183958.793489483 ◽

2014 ◽

Author(s):

John Challiss

Keyword(s):

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Allosteric Modulation ◽

Muscarinic Acetylcholine

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Faculty Opinions recommendation of Activation and allosteric modulation of a muscarinic acetylcholine receptor.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718183958.793487147 ◽

2013 ◽

Author(s):

Bryan Roth

Keyword(s):

Acetylcholine Receptor ◽

Muscarinic Acetylcholine Receptor ◽

Allosteric Modulation ◽

Muscarinic Acetylcholine

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Faculty Opinions recommendation of Boronic acids as probes for investigation of allosteric modulation of the chemokine receptor CXCR3.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718880623.793500089 ◽

2014 ◽

Author(s):

John Lowe

Keyword(s):

Chemokine Receptor ◽

Boronic Acids ◽

Allosteric Modulation

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Faculty Opinions recommendation of Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727343480.793535519 ◽

2017 ◽

Author(s):

Jean-Pierre Changeux

Keyword(s):

Nmda Receptor ◽

Allosteric Modulation

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Allosteric Modulation of Nicotinic Acetylcholine Receptors: The Concept and Therapeutic Trends

Current Pharmaceutical Design ◽

10.2174/1381612822666160201115341 ◽

2016 ◽

Vol 22 (14) ◽

pp. 1986-1997 ◽

Cited By ~ 7

Author(s):

Victor V. Uteshev

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Allosteric Modulation ◽

Nicotinic Acetylcholine

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