scholarly journals Cannabinoid Receptor Interacting Protein 1a Competition with β-Arrestin for CB1 Receptor Binding Sites

2016 ◽  
Vol 91 (2) ◽  
pp. 75-86 ◽  
Author(s):  
Lawrence C. Blume ◽  
Theresa Patten ◽  
Khalil Eldeeb ◽  
Sandra Leone-Kabler ◽  
Alexander A. Ilyasov ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Binding Sites ◽  
Cannabinoid Receptor ◽  
Cb1 Receptor ◽  
Interacting Protein

scholarly journals Cannabinoid Receptor–Interacting Protein 1a Modulates CB1 Receptor Signaling and Regulation

2015 ◽  
Vol 87 (4) ◽  
pp. 747-765 ◽  
Author(s):  
Tricia H. Smith ◽  
Lawrence C. Blume ◽  
Alex Straiker ◽  
Jordan O. Cox ◽  
Bethany G. David ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
Cb1 Receptor ◽  
Receptor Signaling ◽  
Interacting Protein

scholarly journals CB1 receptor binding sites for NAM and PAM: a first approach for studying, new n-butyl-diphenylcarboxamides as allosteric modulators

2021 ◽  
pp. 106088
Author(s):  
Francesca Gado ◽  
Costanza Ceni ◽  
Rebecca Ferrisi ◽  
Giulia Sbrana ◽  
Lesley A. Stevenson ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Binding Sites ◽  
Cb1 Receptor ◽  
Allosteric Modulators

scholarly journals Cannabinoid Receptor Interacting Protein 1a (CRIP1a) Regulates CB1 Receptor Trafficking

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Lawrence C. Blume ◽  
George D. Dalton ◽  
Dana E. Selley ◽  
Allyn C. Howlett
Keyword(s):  
Cannabinoid Receptor ◽  
Cb1 Receptor ◽  
Receptor Trafficking ◽  
Interacting Protein

scholarly journals Cannabinoid Receptor Interacting Protein 1a (CRIP1a): Function and Structure

Molecules ◽  
2019 ◽  
Vol 24 (20) ◽  
pp. 3672 ◽  
Author(s):  
William T. Booth ◽  
Noah B. Walker ◽  
W. Todd Lowther ◽  
Allyn C. Howlett
Keyword(s):  
Metabotropic Glutamate Receptor ◽  
Cannabinoid Receptor ◽  
Cb1 Receptor ◽  
Receptor Internalization ◽  
Receptor Interaction ◽  
Interacting Protein ◽  
Receptor Associated Protein ◽  
Metabotropic Glutamate ◽  
C Terminus

Cannabinoid receptor interacting protein 1a (CRIP1a) is an important CB1 cannabinoid receptor-associated protein, first identified from a yeast two-hybrid screen to modulate CB1-mediated N-type Ca2+ currents. In this paper we review studies of CRIP1a function and structure based upon in vitro experiments and computational chemistry, which elucidate the specific mechanisms for the interaction of CRIP1a with CB1 receptors. N18TG2 neuronal cells overexpressing or silencing CRIP1a highlighted the ability of CRIP1 to regulate cyclic adenosine 3′,5′monophosphate (cAMP) production and extracellular signal-regulated kinase (ERK1/2) phosphorylation. These studies indicated that CRIP1a attenuates the G protein signaling cascade through modulating which Gi/o subtypes interact with the CB1 receptor. CRIP1a also attenuates CB1 receptor internalization via β-arrestin, suggesting that CRIP1a competes for β-arrestin binding to the CB1 receptor. Predictions of CRIP1a secondary structure suggest that residues 34-110 are minimally necessary for association with key amino acids within the distal C-terminus of the CB1 receptor, as well as the mGlu8a metabotropic glutamate receptor. These interactions are disrupted through phosphorylation of serines and threonines in these regions. Through investigations of the function and structure of CRIP1a, new pharmacotherapies based upon the CRIP-CB1 receptor interaction can be designed to treat diseases such as epilepsy, motor dysfunctions and schizophrenia.

scholarly journals Cannabinoid receptor-interacting protein Crip1a modulates CB1 receptor signaling in mouse hippocampus

2015 ◽  
Vol 221 (4) ◽  
pp. 2061-2074 ◽  
Author(s):  
Stephan Guggenhuber ◽  
Alan Alpar ◽  
Rongqing Chen ◽  
Nina Schmitz ◽  
Melanie Wickert ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
Cb1 Receptor ◽  
Receptor Signaling ◽  
Interacting Protein ◽  
Mouse Hippocampus

scholarly journals Cannabinoid receptor interacting protein suppresses agonist-driven CB1 receptor internalization and regulates receptor replenishment in an agonist-biased manner

2016 ◽  
Vol 139 (3) ◽  
pp. 396-407 ◽  
Author(s):  
Lawrence C. Blume ◽  
Sandra Leone-Kabler ◽  
Deborah J. Luessen ◽  
Glen S. Marrs ◽  
Erica Lyons ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
Cb1 Receptor ◽  
Receptor Internalization ◽  
Interacting Protein
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