A Positive Allosteric Modulator of the Adenosine A1 Receptor Selectively Inhibits Primary Afferent Synaptic Transmission in a Neuropathic Pain Model

2015 ◽  
Vol 88 (3) ◽  
pp. 460-468 ◽  
Author(s):  
Wendy L. Imlach ◽  
Rebecca F. Bhola ◽  
Lauren T. May ◽  
Arthur Christopoulos ◽  
Macdonald J. Christie
Keyword(s):  
Neuropathic Pain ◽  
Synaptic Transmission ◽  
Adenosine A1 Receptor ◽  
Allosteric Modulator ◽  
Positive Allosteric Modulator ◽  
Primary Afferent ◽  
Pain Model ◽  
Adenosine A1 ◽  
Neuropathic Pain Model ◽  
A1 Receptor

scholarly journals Involvement of adenosine A1 receptor in electroacupuncture-mediated inhibition of astrocyte activation during neuropathic pain

2018 ◽  
Vol 76 (11) ◽  
pp. 736-742 ◽  
Author(s):  
Mingxiao Zhang ◽  
Qinxue Dai ◽  
Dongdong Liang ◽  
Dan Li ◽  
Sijia Chen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Antinociceptive Effect ◽  
Intrathecal Injection ◽  
Adenosine A1 Receptor ◽  
Astrocyte Activation ◽  
Tnf Α ◽  
Adenosine A1 ◽  
Neuropathic Pain Model ◽  
A1 Receptor

ABSTRACT Neuropathic pain is a chronic pain condition caused by damage or dysfunction of the central or peripheral nervous system. Electroacupuncture (EA) has an antinociceptive effect on neuropathic pain, which is partially due to inhibiting astrocyte activation in the spinal cord. We found that an intrathecal injection of 8-cyclopentyl-1,3-dipropylxanthine (DPCPX), a selective adenosine A1 receptor antagonist, reversed the antinociceptive effects of EA in a chronic constriction injury-induced neuropathic pain model. The expression of GFAP in L4-L6 spinal cord was significantly upgraded, while DPCPX suppressed the effect of the EA-mediating inhibition of astrocyte activation, as well as wiping out the EA-induced suppression of cytokine content (TNF-α). These results indicated that the adenosine A1 receptor is involved in EA actions during neuropathic pain through suppressing astrocyte activation as well as TNF-α upregulation of EA, giving enlightenment to the mechanisms of acupuncture analgesia and development of therapeutic targets for neuropathic pain.

Paeoniflorin exerts analgesic and hypnotic effects via adenosine A1 receptors in a mouse neuropathic pain model

2015 ◽  
Vol 233 (2) ◽  
pp. 281-293 ◽  
Author(s):  
Dou Yin ◽  
Yuan-Yuan Liu ◽  
Tian-Xiao Wang ◽  
Zhen-Zhen Hu ◽  
Wei-Min Qu ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Pain Model ◽  
Adenosine A1 Receptors ◽  
Adenosine A1 ◽  
Neuropathic Pain Model

scholarly journals Downregulation of adenosine and adenosine A1 receptor contributes to neuropathic pain in resiniferatoxin neuropathy

Pain ◽  
2018 ◽  
Vol 159 (8) ◽  
pp. 1580-1591 ◽  
Author(s):  
Hung-Wei Kan ◽  
Chin-Hong Chang ◽  
Chih-Lung Lin ◽  
Yi-Chen Lee ◽  
Sung-Tsang Hsieh ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Adenosine A1 Receptor ◽  
Adenosine A1 ◽  
A1 Receptor

scholarly journals An Allosteric Modulator of the Adenosine A1 Receptor Improves Cardiac Function Following Ischaemia in Murine Isolated Hearts

2013 ◽  
Vol 6 (4) ◽  
pp. 546-556 ◽  
Author(s):  
Anna Butcher ◽  
Peter Scammells ◽  
Paul White ◽  
Shane Devine ◽  
Roselyn Rose'Meyer
Keyword(s):  
Cardiac Function ◽  
Adenosine A1 Receptor ◽  
Allosteric Modulator ◽  
Isolated Hearts ◽  
Adenosine A1 ◽  
A1 Receptor

Pharmacokinetic/pharmacodynamic modelling of the anti-hyperalgesic and anti-nociceptive effect of adenosine A1 receptor partial agonists in neuropathic pain

2005 ◽  
Vol 514 (2-3) ◽  
pp. 131-140 ◽  
Author(s):  
Marloes P. Schaddelee ◽  
Sue D. Collins ◽  
Joost DeJongh ◽  
Albertus G. de Boer ◽  
Adriaan P. IJzerman ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Adenosine A1 Receptor ◽  
Partial Agonists ◽  
Pharmacodynamic Modelling ◽  
Adenosine A1 ◽  
A1 Receptor
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