scholarly journals Targeted Disruption of Organic Cation Transporter 3 Attenuates the Pharmacologic Response to Metformin

2015 ◽  
Vol 88 (1) ◽  
pp. 75-83 ◽  
Author(s):  
Eugene C. Chen ◽  
Xiaomin Liang ◽  
Sook Wah Yee ◽  
Ethan G. Geier ◽  
Sophie L. Stocker ◽  
...  
Keyword(s):  
Organic Cation ◽  
Organic Cation Transporter ◽  
Targeted Disruption ◽  
Pharmacologic Response ◽  
Organic Cation Transporter 3

scholarly journals Targeted Disruption of Organic Cation Transporter 3 (Oct3) Ameliorates Ischemic Brain Damage through Modulating Histamine and Regulatory T Cells

2012 ◽  
Vol 32 (10) ◽  
pp. 1897-1908 ◽  
Author(s):  
Pengxiang Zhu ◽  
Ryuji Hata ◽  
Masahito Ogasawara ◽  
Fang Cao ◽  
Kenji Kameda ◽  
...  
Keyword(s):  
T Cells ◽  
Cerebral Ischemia ◽  
Regulatory T Cells ◽  
Brain Damage ◽  
Organic Cation ◽  
Organic Cation Transporter ◽  
Targeted Disruption ◽  
Ischemic Brain Damage ◽  
Ischemic Brain ◽  
Organic Cation Transporter 3

The organic cation transporters OCT1, 2, and 3 (SLC22A1-3) have been implicated in the elimination of biogenic amines such as histamine. Among them, OCT3 was identified as an uptake-2 transporter, responsible for clearance of histamine. Because increasing evidence suggests the involvement of histamine in cerebral ischemia, we investigated the effects of targeted disruption of organic cation transporter-3 (Oct3) on the severity of ischemic brain damage. Transient focal ischemia for 1 hour was induced by occlusion of the middle cerebral artery (MCA) of homozygous Oct3-deficient mice and their wild-type (Wt) littermates. Although targeted disruption of Oct3 did not affect physiological parameters after MCA occlusion, this disruption significantly increased histamine content in the ischemic cortex and significantly reduced the infarct volume after cerebral ischemia. Furthermore, targeted disruption of Oct3 prevented the reduction of regulatory T-cell proportion after cerebral ischemia while this disruption did not affect Th1 and Th2 cells proportions after ischemia. Since repeated administration of L-histidine (a precursor of histamine) to Wt mice also showed the same effects, our observations suggested that OCT3 is the molecule responsible for clearance of ischemia-induced histamine in the brain and targeted disruption of Oct3 ameliorated ischemic brain damage through an increase in regulatory T cells.

Organic cation transporter 3 ist im hepatischen Kupfermetabolismus involviert

2018 ◽  
Vol 56 (08) ◽  
pp. e250-e250
Author(s):  
S Guttmann ◽  
S Reinartz Groba ◽  
C Niemietz ◽  
V Sandfort ◽  
A Zibert ◽  
...  
Keyword(s):  
Organic Cation ◽  
Organic Cation Transporter ◽  
Organic Cation Transporter 3

scholarly journals Prenatal metformin exposure or organic cation transporter 3 knock-out curbs social interaction preference in male mice

2019 ◽  
Vol 140 ◽  
pp. 21-32 ◽  
Author(s):  
Valentina R. Garbarino ◽  
Taylor A. Santos ◽  
Anastassia R. Nelson ◽  
Wynne Q. Zhang ◽  
Corey M. Smolik ◽  
...  
Keyword(s):  
Social Interaction ◽  
Organic Cation ◽  
Organic Cation Transporter ◽  
Male Mice ◽  
Knock Out ◽  
Organic Cation Transporter 3

scholarly journals Corticosterone Potentiation of Cocaine-Induced Reinstatement of Conditioned Place Preference in Mice is Mediated by Blockade of the Organic Cation Transporter 3

2016 ◽  
Vol 42 (3) ◽  
pp. 757-765 ◽  
Author(s):  
Jayme R McReynolds ◽  
Analisa Taylor ◽  
Oliver Vranjkovic ◽  
Terra Ambrosius ◽  
Olivia Derricks ◽  
...  
Keyword(s):  
Conditioned Place Preference ◽  
Organic Cation ◽  
Organic Cation Transporter ◽  
Place Preference ◽  
Organic Cation Transporter 3

scholarly journals Real-time uptake of fluorescent ASP+ via the organic cation transporter 3

2012 ◽  
Vol 13 (Suppl 1) ◽  
pp. A80
Author(s):  
Felix P Mayer ◽  
Diethart Schmid ◽  
Marion Holy ◽  
Jae-Won Yang ◽  
Isabella Salzer ◽  
...  
Keyword(s):  
Real Time ◽  
Organic Cation ◽  
Organic Cation Transporter ◽  
Organic Cation Transporter 3
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