scholarly journals A Peptide Mimicking a Region in Proliferating Cell Nuclear Antigen Specific to Key Protein Interactions Is Cytotoxic to Breast Cancer

2014 ◽  
Vol 87 (2) ◽  
pp. 263-276 ◽  
Author(s):  
Shanna J. Smith ◽  
Long Gu ◽  
Elizabeth A. Phipps ◽  
Lacey E. Dobrolecki ◽  
Karla S. Mabrey ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Protein Interactions ◽  
Proliferating Cell Nuclear Antigen ◽  
Nuclear Antigen ◽  
Proliferating Cell

scholarly journals Maneuvers on PCNA Rings during DNA Replication and Repair

Genes ◽  
2018 ◽  
Vol 9 (8) ◽  
pp. 416 ◽  
Author(s):  
Dea Slade
Keyword(s):  
Dna Replication ◽  
Protein Interactions ◽  
Proliferating Cell Nuclear Antigen ◽  
Binding Proteins ◽  
Nuclear Antigen ◽  
Vast Number ◽  
Post Translational Modifications ◽  
Dna Replication And Repair ◽  
Replicative Polymerases ◽  
Proliferating Cell

DNA replication and repair are essential cellular processes that ensure genome duplication and safeguard the genome from deleterious mutations. Both processes utilize an abundance of enzymatic functions that need to be tightly regulated to ensure dynamic exchange of DNA replication and repair factors. Proliferating cell nuclear antigen (PCNA) is the major coordinator of faithful and processive replication and DNA repair at replication forks. Post-translational modifications of PCNA, ubiquitination and acetylation in particular, regulate the dynamics of PCNA-protein interactions. Proliferating cell nuclear antigen (PCNA) monoubiquitination elicits ‘polymerase switching’, whereby stalled replicative polymerase is replaced with a specialized polymerase, while PCNA acetylation may reduce the processivity of replicative polymerases to promote homologous recombination-dependent repair. While regulatory functions of PCNA ubiquitination and acetylation have been well established, the regulation of PCNA-binding proteins remains underexplored. Considering the vast number of PCNA-binding proteins, many of which have similar PCNA binding affinities, the question arises as to the regulation of the strength and sequence of their binding to PCNA. Here I provide an overview of post-translational modifications on both PCNA and PCNA-interacting proteins and discuss their relevance for the regulation of the dynamic processes of DNA replication and repair.

scholarly journals The Prognostic Implications of Macrophages Expressing Proliferating Cell Nuclear Antigen in Breast Cancer Depend on Immune Context

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e79114 ◽  
Author(s):  
Michael J. Campbell ◽  
Denise Wolf ◽  
Rita A. Mukhtar ◽  
Vickram Tandon ◽  
Christina Yau ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Proliferating Cell Nuclear Antigen ◽  
Nuclear Antigen ◽  
Prognostic Implications ◽  
Proliferating Cell
Sign in / Sign up

Export Citation Format

Share Document