scholarly journals Functional Validation of Virtual Screening for Novel Agents with General Anesthetic Action at Ligand-Gated Ion Channels

2013 ◽  
Vol 84 (5) ◽  
pp. 670-678 ◽  
Author(s):  
Stephanie A. Heusser ◽  
Rebecca J. Howard ◽  
Cecilia M. Borghese ◽  
Madeline A. Cullins ◽  
Torben Broemstrup ◽  
...  
Keyword(s):  
Ion Channels ◽  
Virtual Screening ◽  
Novel Agents ◽  
General Anesthetic ◽  
Functional Validation ◽  
Anesthetic Action ◽  
Gated Ion Channels ◽  
Ligand Gated Ion Channels

scholarly journals Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels

Cell Reports ◽  
2018 ◽  
Vol 23 (4) ◽  
pp. 993-1004 ◽  
Author(s):  
Zaineb Fourati ◽  
Rebecca J. Howard ◽  
Stephanie A. Heusser ◽  
Haidai Hu ◽  
Reinis R. Ruza ◽  
...  
Keyword(s):  
Ion Channels ◽  
Structural Basis ◽  
General Anesthetic ◽  
Allosteric Mechanism ◽  
Gated Ion Channels ◽  
Ligand Gated Ion Channels

Approaches to proving there are general anesthetic sites on ligand gated ion channels

1998 ◽  
Vol 100-101 ◽  
pp. 139-147 ◽  
Author(s):  
Keith W Miller ◽  
George H Addona ◽  
Marek A Kloczewiak
Keyword(s):  
Ion Channels ◽  
General Anesthetic ◽  
Gated Ion Channels ◽  
Ligand Gated Ion Channels
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