Phosphodiesterase 4 Inhibitors Augment the Ability of Formoterol to Enhance Glucocorticoid-Dependent Gene Transcription in Human Airway Epithelial Cells: A Novel Mechanism for the Clinical Efficacy of Roflumilast in Severe Chronic Obstructive Pulmonary Disease

Thunicia Moodley; Sylvia M. Wilson; Taruna Joshi; Christopher F. Rider; Pawan Sharma; Dong Yan; Robert Newton; Mark A. Giembycz

doi:10.1124/mol.112.083493

Phosphodiesterase 4 Inhibitors Augment the Ability of Formoterol to Enhance Glucocorticoid-Dependent Gene Transcription in Human Airway Epithelial Cells: A Novel Mechanism for the Clinical Efficacy of Roflumilast in Severe Chronic Obstructive Pulmonary Disease

Molecular Pharmacology ◽

10.1124/mol.112.083493 ◽

2013 ◽

Vol 83 (4) ◽

pp. 894-906 ◽

Cited By ~ 33

Author(s):

Thunicia Moodley ◽

Sylvia M. Wilson ◽

Taruna Joshi ◽

Christopher F. Rider ◽

Pawan Sharma ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Epithelial Cells ◽

Pulmonary Disease ◽

Gene Transcription ◽

Airway Epithelial Cells ◽

Chronic Obstructive ◽

Airway Epithelial ◽

Obstructive Pulmonary Disease ◽

Phosphodiesterase 4 ◽

Phosphodiesterase 4 Inhibitors

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Phosphodiesterase 4 Inhibitors Enhance Glucocorticoid-Dependent Gene Transcription In Human Airway Epithelial Cells: A Mechanism For The Clinical Efficacy Of Roflumilast In Severe Chronic Obstructive Pulmonary Disease

10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5691 ◽

2012 ◽

Author(s):

Thunicia Moodley ◽

Sylvia Wilson ◽

Taruna Joshi ◽

Pawan Sharma ◽

Christopher F. Rider ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Epithelial Cells ◽

Pulmonary Disease ◽

Gene Transcription ◽

Airway Epithelial Cells ◽

Chronic Obstructive ◽

Airway Epithelial ◽

Obstructive Pulmonary Disease ◽

Phosphodiesterase 4 ◽

Phosphodiesterase 4 Inhibitors

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Increased Cytokine Response Of Rhinovirus-Infected Airway Epithelial Cells In Chronic Obstructive Pulmonary Disease

10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4236 ◽

2010 ◽

Author(s):

Dina Schneider ◽

Adam Comstock ◽

Shyamala Ganesan ◽

Catherine A. Meldrum ◽

Raja Mahidhara ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Epithelial Cells ◽

Pulmonary Disease ◽

Airway Epithelial Cells ◽

Cytokine Response ◽

Chronic Obstructive ◽

Airway Epithelial ◽

Obstructive Pulmonary Disease

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Adiponectin and Functional Adiponectin Receptor 1 Are Expressed by Airway Epithelial Cells in Chronic Obstructive Pulmonary Disease

The Journal of Immunology ◽

10.4049/jimmunol.182.1.684 ◽

2008 ◽

Vol 182 (1) ◽

pp. 684-691 ◽

Cited By ~ 110

Author(s):

Marina Miller ◽

Jae Youn Cho ◽

Alexa Pham ◽

Joe Ramsdell ◽

David H. Broide

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Epithelial Cells ◽

Pulmonary Disease ◽

Airway Epithelial Cells ◽

Adiponectin Receptor ◽

Chronic Obstructive ◽

Airway Epithelial ◽

Obstructive Pulmonary Disease ◽

Adiponectin Receptor 1

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Faculty Opinions recommendation of Increased cytokine response of rhinovirus-infected airway epithelial cells in chronic obstructive pulmonary disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.3024956.5106054 ◽

2010 ◽

Author(s):

Jadwiga Wedzicha ◽

Alexander Mackay

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Epithelial Cells ◽

Pulmonary Disease ◽

Airway Epithelial Cells ◽

Cytokine Response ◽

Chronic Obstructive ◽

Airway Epithelial ◽

Obstructive Pulmonary Disease

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Impaired nuclear factor erythroid 2-related factor 2 expression increases apoptosis of airway epithelial cells in patients with chronic obstructive pulmonary disease due to cigarette smoking

BMC Pulmonary Medicine ◽

10.1186/s12890-016-0189-1 ◽

2016 ◽

Vol 16 (1) ◽

Cited By ~ 20

Author(s):

Kazuhiro Yamada ◽

Kazuhisa Asai ◽

Fumihiro Nagayasu ◽

Kanako Sato ◽

Naoki Ijiri ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Epithelial Cells ◽

Cigarette Smoking ◽

Pulmonary Disease ◽

Airway Epithelial Cells ◽

Chronic Obstructive ◽

Related Factor ◽

Nuclear Factor ◽

Airway Epithelial ◽

Obstructive Pulmonary Disease

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Targeting c-Src Reverses Accelerated GPX-1 mRNA Decay in Chronic Obstructive Pulmonary Disease Airway Epithelial Cells

American Journal of Respiratory Cell and Molecular Biology ◽

10.1165/rcmb.2019-0177oc ◽

2020 ◽

Vol 62 (5) ◽

pp. 598-607 ◽

Cited By ~ 1

Author(s):

Abdoulaye J. Dabo ◽

Wendy Ezegbunam ◽

Anne E. Wyman ◽

Jane Moon ◽

Christopher Railwah ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Epithelial Cells ◽

Pulmonary Disease ◽

Mrna Decay ◽

Airway Epithelial Cells ◽

Chronic Obstructive ◽

Airway Epithelial ◽

Obstructive Pulmonary Disease

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Increased Cytokine Response of Rhinovirus-infected Airway Epithelial Cells in Chronic Obstructive Pulmonary Disease

American Journal of Respiratory and Critical Care Medicine ◽

10.1164/rccm.200911-1673oc ◽

2010 ◽

Vol 182 (3) ◽

pp. 332-340 ◽

Cited By ~ 112

Author(s):

Dina Schneider ◽

Shyamala Ganesan ◽

Adam T. Comstock ◽

Catherine A. Meldrum ◽

Raja Mahidhara ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Epithelial Cells ◽

Pulmonary Disease ◽

Airway Epithelial Cells ◽

Cytokine Response ◽

Chronic Obstructive ◽

Airway Epithelial ◽

Obstructive Pulmonary Disease

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Concurrent Agonism of Adenosine A2B and Glucocorticoid Receptors in Human Airway Epithelial Cells Cooperatively Induces Genes with Anti-Inflammatory Potential: A Novel Approach to Treat Chronic Obstructive Pulmonary Disease

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.113.206284 ◽

2013 ◽

Vol 346 (3) ◽

pp. 473-485 ◽

Cited By ~ 23

Author(s):

Stephanie Greer ◽

Cara W. Page ◽

Taruna Joshi ◽

Dong Yan ◽

Robert Newton ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Epithelial Cells ◽

Pulmonary Disease ◽

Glucocorticoid Receptors ◽

Airway Epithelial Cells ◽

Chronic Obstructive ◽

Airway Epithelial ◽

Obstructive Pulmonary Disease ◽

Novel Approach ◽

Adenosine A2b

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Identification of Novel Genes in Human Airway Epithelial Cells associated with Chronic Obstructive Pulmonary Disease (COPD) using Machine-Based Learning Algorithms

Scientific Reports ◽

10.1038/s41598-018-33986-8 ◽

2018 ◽

Vol 8 (1) ◽

Cited By ~ 6

Author(s):

Shayan Mostafaei ◽

Anoshirvan Kazemnejad ◽

Sadegh Azimzadeh Jamalkandi ◽

Soroush Amirhashchi ◽

Seamas C. Donnelly ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Epithelial Cells ◽

Pulmonary Disease ◽

Learning Algorithms ◽

Airway Epithelial Cells ◽

Chronic Obstructive ◽

Airway Epithelial ◽

Novel Genes ◽

Obstructive Pulmonary Disease ◽

Human Airway

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Mucosal Associated Invariant T Cell Function in Response to Human Airway Epithelial Cells Is Dysregulated in the Context of Cigarette Smoke and Chronic Obstructive Pulmonary Disease

10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6526 ◽

2020 ◽

Author(s):

M. Harriff ◽

E. Larson ◽

M. Leiser

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

T Cell ◽

Epithelial Cells ◽

Pulmonary Disease ◽

Cigarette Smoke ◽

Cell Function ◽

Airway Epithelial Cells ◽

Chronic Obstructive ◽

Airway Epithelial ◽

Obstructive Pulmonary Disease

Download Full-text