Synthesis of Selective Agonists for the α7 Nicotinic Acetylcholine Receptor with In Situ Click-Chemistry on Acetylcholine-Binding Protein Templates

John G. Yamauchi; Kimberly Gomez; Neil Grimster; Mikael Dufouil; Ákos Nemecz; Joseph R. Fotsing; Kwok-Yiu Ho; Todd T. Talley; K. Barry Sharpless; Valery V. Fokin; Palmer Taylor

doi:10.1124/mol.112.080291

Synthesis of Selective Agonists for the α7 Nicotinic Acetylcholine Receptor with In Situ Click-Chemistry on Acetylcholine-Binding Protein Templates

Molecular Pharmacology ◽

10.1124/mol.112.080291 ◽

2012 ◽

Vol 82 (4) ◽

pp. 687-699 ◽

Cited By ~ 14

Author(s):

John G. Yamauchi ◽

Kimberly Gomez ◽

Neil Grimster ◽

Mikael Dufouil ◽

Ákos Nemecz ◽

...

Keyword(s):

Click Chemistry ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Binding Protein ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Acetylcholine Binding Protein ◽

Selective Agonists

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An allosteric binding site of the α7 nicotinic acetylcholine receptor revealed in a humanized acetylcholine-binding protein

Journal of Biological Chemistry ◽

10.1074/jbc.m117.815316 ◽

2017 ◽

Vol 293 (7) ◽

pp. 2534-2545 ◽

Cited By ~ 15

Author(s):

Florian Delbart ◽

Marijke Brams ◽

Fabian Gruss ◽

Sam Noppen ◽

Steve Peigneur ◽

...

Keyword(s):

Binding Site ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Binding Protein ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Acetylcholine Binding Protein

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Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor

The EMBO Journal ◽

10.1038/emboj.2009.227 ◽

2009 ◽

Vol 28 (19) ◽

pp. 3040-3051 ◽

Cited By ~ 119

Author(s):

Ryan E Hibbs ◽

Gerlind Sulzenbacher ◽

Jianxin Shi ◽

Todd T Talley ◽

Sandrine Conrod ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Binding Protein ◽

Structural Determinants ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Acetylcholine Binding Protein ◽

Partial Agonists

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Alpha‐7 Nicotinic Acetylcholine Receptor (nAChR) Characteristics on the Acetylcholine Binding Protein

The FASEB Journal ◽

10.1096/fasebj.23.1_supplement.942.4 ◽

2009 ◽

Vol 23 (S1) ◽

Author(s):

Ákos Nemecz ◽

Palmer Taylor

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Binding Protein ◽

Nicotinic Acetylcholine ◽

Acetylcholine Binding Protein ◽

Alpha 7

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Design and synthesis of a hybrid series of potent and selective agonists of α7 nicotinic acetylcholine receptor

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2014.03.031 ◽

2014 ◽

Vol 78 ◽

pp. 401-418 ◽

Cited By ~ 12

Author(s):

Arianna Nencini ◽

Cristiana Castaldo ◽

Thomas A. Comery ◽

John Dunlop ◽

Eva Genesio ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Design And Synthesis ◽

Selective Agonists

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Generation of Candidate Ligands for Nicotinic Acetylcholine Receptors via in situ Click Chemistry with a Soluble Acetylcholine Binding Protein Template

Journal of the American Chemical Society ◽

10.1021/ja3001858 ◽

2012 ◽

Vol 134 (15) ◽

pp. 6732-6740 ◽

Cited By ~ 63

Author(s):

Neil P. Grimster ◽

Bernhard Stump ◽

Joseph R. Fotsing ◽

Timo Weide ◽

Todd T. Talley ◽

...

Keyword(s):

Click Chemistry ◽

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Binding Protein ◽

Nicotinic Acetylcholine ◽

Acetylcholine Binding Protein

Download Full-text

Activation of α7 nicotinic acetylcholine receptor alleviates cerebral cortical neuron injury induced by oxygen-glucose deprivation

Academic Journal of Second Military Medical University ◽

10.3724/sp.j.1008.2015.00472 ◽

2015 ◽

Vol 36 (5) ◽

pp. 472

Author(s):

Ru-juan XIN ◽

Ting ZHAO ◽

Min NI ◽

Dong-jie LI ◽

Fu-ming SHEN

Keyword(s):

Cortical Neuron ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Glucose Deprivation ◽

Oxygen Glucose Deprivation ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Cerebral Cortical Neuron ◽

Neuron Injury

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Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113189 ◽

2021 ◽

Vol 214 ◽

pp. 113189

Author(s):

István Ledneczki ◽

Pál Tapolcsányi ◽

Eszter Gábor ◽

András Visegrády ◽

Márton Vass ◽

...

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Allosteric Modulators ◽

Scaffold Hopping ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Positive Allosteric Modulators

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Retracted : Role of α7‐nicotinic acetylcholine receptor in human non‐small cell lung cancer proliferation

Cell Proliferation ◽

10.1111/j.1365-2184.2008.00566.x ◽

2008 ◽

Vol 41 (6) ◽

pp. 936-959 ◽

Cited By ~ 57

Author(s):

L. Paleari ◽

A. Catassi ◽

M. Ciarlo ◽

Z. Cavalieri ◽

C. Bruzzo ◽

...

Keyword(s):

Lung Cancer ◽

Small Cell Lung Cancer ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Small Cell ◽

Small Cell Lung ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Cancer Proliferation ◽

Nicotinic Acetylcholine

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Nicotine Accelerates Atherosclerosis in Apolipoprotein E–Deficient Mice by Activating α7 Nicotinic Acetylcholine Receptor on Mast Cells

Arteriosclerosis Thrombosis and Vascular Biology ◽

10.1161/atvbaha.116.307264 ◽

2017 ◽

Vol 37 (1) ◽

pp. 53-65 ◽

Cited By ~ 27

Author(s):

Chen Wang ◽

Han Chen ◽

Wei Zhu ◽

Yinchuan Xu ◽

Mingfei Liu ◽

...

Keyword(s):

Mast Cells ◽

Apolipoprotein E ◽

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine ◽

Deficient Mice

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Serotonin antagonizes the human neuronal α7 nicotinic acetylcholine receptor and becomes an agonist after L248T α7 mutation

Neuroscience ◽

10.1016/s0306-4522(01)00567-x ◽

2002 ◽

Vol 110 (1) ◽

pp. 169-179 ◽

Cited By ~ 14

Author(s):

S Fucile ◽

E Palma ◽

F Eusebi ◽

R Miledi

Keyword(s):

Acetylcholine Receptor ◽

Nicotinic Acetylcholine Receptor ◽

Α7 Nicotinic Acetylcholine Receptor ◽

Nicotinic Acetylcholine

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