The Polyphenolic Ellagitannin Vescalagin Acts As a Preferential Catalytic Inhibitor of the α Isoform of Human DNA Topoisomerase II

2012 ◽  
Vol 82 (1) ◽  
pp. 134-141 ◽  
Author(s):  
Céline Auzanneau ◽  
Danièle Montaudon ◽  
Rémi Jacquet ◽  
Stéphane Puyo ◽  
Laurent Pouységu ◽  
...  
Keyword(s):  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Catalytic Inhibitor

scholarly journals Identification of potent catalytic inhibitors of human DNA topoisomerase II by structure-based virtual screening

MedChemComm ◽  
2018 ◽  
Vol 9 (7) ◽  
pp. 1142-1146 ◽  
Author(s):  
Guoqiang Dong ◽  
Ying Wu ◽  
Ying Sun ◽  
Na Liu ◽  
Shanchao Wu ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Virtual Screening ◽  
Antiproliferative Activity ◽  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Catalytic Inhibitor ◽  
Anticancer Drug Discovery

Structure-based virtual screening was performed and led to 14 novel Top2 catalytic inhibitors. Compound 8 was proven to be a Top2 catalytic inhibitor and showed good in vitro antiproliferative activity. It holds great potential for further hit-to-lead development in anticancer drug discovery.

Antitumor Agents, 107. New Cytotoxic 4-Alkylamino Analogues of 4'-Demethyl-Epipodophyllotoxin as Inhibitors of Human DNA Topoisomerase II

1989 ◽  
Vol 52 (3) ◽  
pp. 606-613 ◽  
Author(s):  
Kuo-Hsiung Lee ◽  
Yasuhiro Imakura ◽  
Mitsumasa Haruna ◽  
Scott A. Beers ◽  
Lee S. Thurston ◽  
...  
Keyword(s):  
Topoisomerase Ii ◽  
Antitumor Agents ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Human Dna

scholarly journals Phaeophytins from Thyrsacanthus ramosissimus Moric. with inhibitory activity on human dna topoisomerase II-α

Química Nova ◽  
2012 ◽  
Vol 35 (11) ◽  
pp. 2222-2225 ◽  
Author(s):  
Analúcia Guedes Silveira Cabral ◽  
Fábio Henrique Tenório-Souza ◽  
Marcelo Dantas Moura ◽  
Sabrina Gondim Ribeiro Mota ◽  
Antônio Cláudio da Silva Lins ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Human Dna

Interaction of Human DNA Topoisomerase II α with DNA:  Quantification by Surface Plasmon Resonance†

Biochemistry ◽  
2002 ◽  
Vol 41 (45) ◽  
pp. 13395-13402 ◽  
Author(s):  
Axelle Renodon-Cornière ◽  
Lars H. Jensen ◽  
John L. Nitiss ◽  
Peter B. Jensen ◽  
Maxwell Sehested
Keyword(s):  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Topoisomerase Ii ◽  
Dna Quantification ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Topoisomerase Ii Α

Atypical multidrug resistance may be associated with catalytically active mutants of human DNA topoisomerase II α

Gene ◽  
2001 ◽  
Vol 272 (1-2) ◽  
pp. 141-148 ◽  
Author(s):  
Yoshito Okada ◽  
Aki Tosaka ◽  
Yuji Nimura ◽  
Akihiko Kikuchi ◽  
Shonen Yoshida ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Topoisomerase Ii ◽  
Dna Topoisomerase Ii ◽  
Dna Topoisomerase ◽  
Human Dna ◽  
Catalytically Active ◽  
Topoisomerase Ii Α
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