DC120, a Novel and Potent Inhibitor of AKT Kinase, Induces Tumor Cell Apoptosis and Suppresses Tumor Growth

2012 ◽  
Vol 82 (2) ◽  
pp. 189-198 ◽  
Author(s):  
Rong Deng ◽  
Fen Yang ◽  
Shao-hua Chang ◽  
Jun Tang ◽  
Juan Qin ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Tumor Cell ◽  
Cell Apoptosis ◽  
Potent Inhibitor ◽  
Akt Kinase ◽  
Tumor Cell Apoptosis

Immunotherapy with Recombinant Xenogeneic Vascular Endothelial Growth Factor as a Vaccine Combined Low-Dose Adriamycin Induces Synergistic Antitumor Efficacy in EL4 Lymphoma Model.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 4811-4811
Author(s):  
Ting Niu ◽  
Ting Liu ◽  
Yong-qian Jia ◽  
Yan-jun Wen ◽  
Ling Tian ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Tumor Growth ◽  
Tumor Cell ◽  
Cell Apoptosis ◽  
Low Dose ◽  
Combination Group ◽  
Vascular Endothelial ◽  
Tumor Cell Apoptosis ◽  
Anti Vegf ◽  
Endothelial Growth Factor

Abstract We explored the antitumor efficacy of a strategy using recombinant Xenopus laevis vascular endothelial growth factor (xVEGF) as a xenogeneic protein vaccine, which we have demonstrated to have effective antiangiogenic activities in several tumor models, in combination with low-dose adriamycin in lymphoma model. EL4 lymphoma model was established in C57BL/6 mice. Mice were randomly divided into four groups: combination therapy (xVEGF plus adriamycin), xVEGF treatment alone, adriamycin treatment alone, and normal saline (NS) groups, and received relevant treatments. Tumor growth, survival rate of tumor-bearing mice, and potential toxicity of regimens above were investigated. Anti-VEGF antibodies and anti-VEGF antibody-producing B cells (APBCs) were detected by Western blot analysis and enzyme-linked immunospot (ELISPOT) assay, respectively. In addition, microvessel density (MVD) within tumor tissues and tumor cell apoptosis were determined by immunohistochemistry and TUNEL staining, respectively. Our data showed that combination therapy inhibited tumor growth and improved survival of tumor-bearing mice significantly, and complete regression of tumor was observed in 3 of 10 mice in combination group in EL4 lymphoma model.Survival rate of mice was significantly higher in combination group than that in xVEGF alone group,in adriamycin alone group (P<0.05),or that in NS group (P<0.01). Remarkably, the combination treatment resulted in not only significant antiangiogenic effects but also promotion of tumor cell apoptosis. The calculated indexes of combination therapy showed synergistic relationship in terms of inhibition of tumor growth, antiangiogenesis, induction of tumor cell apoptosis. In addition, anti-VEGF antibodies and APBCs were found in mice treated with either xVEGF vaccine alone or combination treatment. No marked toxicities were found in the treated mice. In summary, these findings may provide an effective combination approach for lymphoma therapy in the future.

scholarly journals Antitumor Effect of Periplocin in TRAIL-Resistant Human Hepatocellular Carcinoma Cells through Downregulation of IAPs

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Chieh-Fang Cheng ◽  
I-Huang Lu ◽  
Hsiang-Wen Tseng ◽  
Chung-Yuan Sun ◽  
Li-Tsen Lin ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Growth ◽  
Tumor Cell ◽  
Cell Apoptosis ◽  
Cardiac Glycosides ◽  
Chinese Herb ◽  
Carcinoma Cells ◽  
Root Bark ◽  
Tumor Cell Apoptosis ◽  
Hepatocellular Carcinoma Cells

Cortex periplocae is the dried root bark ofPeriploca sepiumBge., a traditional Chinese herb medicine. It contains high amounts of cardiac glycosides. Several cardiac glycosides have been reported to inhibit tumor growth or induce tumor cell apoptosis. We extracted and purified cortex periplocae and identified periplocin as the active ingredient that inhibited the growth of TNF-related apoptosis-inducing ligand-(TRAIL-) resistant hepatocellular carcinoma cells. The antitumor activity of periplocin was further increased by TRAIL cotreatment. Periplocin sensitized TRAIL-resistant HCC through the following two mechanisms. First, periplocin induced the expression of DR4 and FADD. Second, the cotreatment of TRAIL and periplocin suppressed several inhibitors of apoptosis (IAPs). Both mechanisms resulted in the activation of caspase 3, 8, and 9 and led to cell apoptosis. In addition, intraperitoneal injection (IP) of periplocin repressed the growth of hepatocellular carcinoma (HCC) in xenograft tumor model in mice. In summary, periplocin sensitized TRAIL-resistant HCC cells to TRAIL treatment and resulted in tumor cell apoptosis and the repression of tumor growthin vivo.

First-in-class cell penetrating proteins targeting Mcl-1 induce tumor cell apoptosis and inhibition of tumor growth in vivo

2016 ◽  
Vol 69 ◽  
pp. S132-S133
Author(s):  
S. Thiolloy ◽  
J. Desmet ◽  
F. Baatz ◽  
S. Loverix ◽  
K. Vandenbroucke ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Tumor Cell ◽  
Cell Apoptosis ◽  
Tumor Cell Apoptosis ◽  
Cell Penetrating ◽  
Inhibition Of Tumor Growth

Mechanism of TRAIL Induced Tumor Cell Apoptosis and Application of TRAIL Based on Tumor Therapy

2012 ◽  
Vol 28 (6) ◽  
pp. 448 ◽  
Author(s):  
Ling ZHU ◽  
Xiangxi WANG ◽  
Xuemei LI ◽  
Jinliang YANG
Keyword(s):  
Tumor Cell ◽  
Cell Apoptosis ◽  
Tumor Therapy ◽  
Tumor Cell Apoptosis

scholarly journals Hsp60 Regulation of Tumor Cell Apoptosis

2007 ◽  
Vol 283 (8) ◽  
pp. 5188-5194 ◽  
Author(s):  
Jagadish C. Ghosh ◽  
Takehiko Dohi ◽  
Byoung Heon Kang ◽  
Dario C. Altieri
Keyword(s):  
Tumor Cell ◽  
Cell Apoptosis ◽  
Tumor Cell Apoptosis
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