Galangin Suppresses the Proliferation of β-Catenin Response Transcription-Positive Cancer Cells by Promoting Adenomatous Polyposis Coli/Axin/Glycogen Synthase Kinase-3β-Independent β-Catenin Degradation

2011 ◽  
Vol 79 (6) ◽  
pp. 1014-1022 ◽  
Author(s):  
Jungsug Gwak ◽  
Jingyo Oh ◽  
Munju Cho ◽  
Soo Kyung Bae ◽  
Im-Sook Song ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Adenomatous Polyposis Coli ◽  
Glycogen Synthase ◽  
Glycogen Synthase Kinase ◽  
Adenomatous Polyposis ◽  
Glycogen Synthase Kinase 3Β ◽  
Polyposis Coli

scholarly journals Genes regulating membrane-associated E-cadherin and proliferation in adenomatous polyposis coli mutant colon cancer cells: High content siRNA screen

PLoS ONE ◽  
2020 ◽  
Vol 15 (10) ◽  
pp. e0240746
Author(s):  
Lauren E. King ◽  
Hui-Hua Zhang ◽  
Cathryn M. Gould ◽  
Daniel W. Thomas ◽  
Lachlan W. Whitehead ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Adenomatous Polyposis Coli ◽  
Adenomatous Polyposis ◽  
Colon Cancer Cells ◽  
Polyposis Coli ◽  
Sirna Screen ◽  
Coli Mutant ◽  
E Cadherin

The effects of genistein and daidzein on cell proliferation kinetics in HT29 colon cancer cells: the expression of CTNNBIP1 (β-catenin), APC (adenomatous polyposis coli) and BIRC5 (survivin)

Human Cell ◽  
2014 ◽  
Vol 27 (2) ◽  
pp. 78-84 ◽  
Author(s):  
Sandra Regina Lepri ◽  
Leonardo Campos Zanelatto ◽  
Patrícia Benites Gonçalves da Silva ◽  
Daniele Sartori ◽  
Lucia Regina Ribeiro ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Adenomatous Polyposis Coli ◽  
Adenomatous Polyposis ◽  
Colon Cancer Cells ◽  
Polyposis Coli ◽  
Proliferation Kinetics

scholarly journals Interaction of Dishevelled and XenopusAxin-Related Protein Is Required for Wnt Signal Transduction

2000 ◽  
Vol 20 (6) ◽  
pp. 2228-2238 ◽  
Author(s):  
Keiji Itoh ◽  
Alena Antipova ◽  
Marianne J. Ratcliffe ◽  
Sergei Sokol
Keyword(s):  
Signal Transduction ◽  
Adenomatous Polyposis Coli ◽  
Glycogen Synthase ◽  
Secreted Proteins ◽  
Glycogen Synthase Kinase 3 ◽  
Adenomatous Polyposis ◽  
Related Protein ◽  
Polyposis Coli ◽  
Animal Development ◽  
Wnt Signal

ABSTRACT Signaling by the Wnt family of secreted proteins plays an important role in animal development and is often misregulated in carcinogenesis. Wnt signal transduction is controlled by the rate of degradation of β-catenin by a complex of proteins including glycogen synthase kinase 3 (GSK3), adenomatous polyposis coli, and Axin. Dishevelled is required for Wnt signal transduction, and its activation results in stabilization of β-catenin. However, the biochemical events underlying this process remain largely unclear. Here we show thatXenopus Dishevelled (Xdsh) interacts with aXenopus Axin-related protein (XARP). This interaction depends on the presence of the Dishevelled-Axin (DIX) domains in both XARP and Xdsh. Moreover, the same domains are essential for signal transduction through Xdsh. Finally, our data point to a possible mechanism for signal transduction, in which Xdsh prevents β-catenin degradation by displacing GSK3 from its complex with XARP.

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